Multiple Imputation of Missing Values Using the Response Function Method Based on a Data Set of the Health Assessment Questionnaire Disability Index

Caution Should Be Observed Against the Last Observation Carried Forward Analysis in Opioid Trials

“…To accurately estimate the magnitude of treatment efficacy, caution should be observed regarding the LOCF analytical bias. In this respect, the study by Erdogan et al [5] is to be congratulated.…”

“…[3] In fact, the bias caused by the LOCF approach has been demonstrated in simulation studies using knee OA data [4] and rheumatoid arthritis (RA) and osteoarthritis (OA) data. [5] To confirm this possibility in "real" knee OA data, we searched the MEDLINE, Scopus, and the Cochrane Central Register of Controlled Trials (CENTRAL) databases for randomized, placebocontrolled trials that had been published through December 2011, and extracted data from 294 studies, that including dropouts in the treatment and placebo groups. The pooled dropout rate, based on a random effects model, was 14.7% [95% confidence interval (CI): 13.6-15.9].…”