Multiple hyperpigmented nodules. Multiple dermatofibromas in a patient with systemic lupus erythematosus (SLE)

Multiple Dermatofibromas Accompanied by Eruptive Benign Keratoses in a Patient with Systemic Lupus Erythematosus

“…Multiple DFs have been described in 18 patients with autoimmune disease, altered immunity, or both. In this group, associations with SLE (2-4, 6-11), myathenia gravis (5), Sjogren's syndrome (6), ulcerative colitis (7), pemphigus vulgaris (7), atopic dermatitis (12), and HIV infection (10), or a history of immunosuppressive therapy with azathioprine (2,9), prednisone (2, 5-11), or cyclophosphamide (5, 11) have been noted. The etiology ofDF remains unclear.…”

“…While dermatofibromas (DFs) are common on the lower extremities, occurrence of multiple DFs (15 or more) is rare (1). Previously, several authors have described cases of multiple DFs associated with autoimmune disorder, altered immunity, or both (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12). In contrast, eruptive benign keratoses (BK) are described in patients with psoriasis undergoing cyclosporin A therapy (13,14).…”

A Case of Idiopathic Dermatofibromatosis

“…5 MED tanısı ile bildirilen olgularda eşlik eden otoimmün hastalıklar arasında SLE, Sjögren sendromu, miyasteni gravis, pemfigus vulgaris, dermatomiyozit gibi hastalıklar bildirilmiştir. [14][15][16][17][18][19][20][21] Ayrıca HIV enfeksiyonu, atopik dermatit, miyelodisplastik sendrom ve gebelik ilişkilendirilen diğer durumlardır. İyatrojenik immünsupresyon vakalarında da MED gelişimi bildirilmiştir.…”

Multiple eruptive dermatofibromas in a patient with dermatomyositis taking prednisolone and methotrexate

“…Previous reports suggest that immunosuppressants, such as corticosteroids, cyclophosphamide, and azathioprine, are related to the occurrence of MEDFs. 1,2,[4][5][6][7][8][9][10][11]13,14,26,32 Our patient had received methotrexate and corticosteroid treatment for 3 months and 2 months, respectively, before developing MEDFs. The patient had received systemic corticosteroids intermittently during the last 10 years, during which no MEDFs occurred.…”

“…The occurrence of multiple eruptive DF (MEDF) is rare. Since the initial observation of Cohen 1 of the association among MEDFs, autoimmune diseases, and immunosuppressive therapy, MEDFs have been associated with autoimmune diseases, 1-14 immunosuppressant therapy, 1,2,[4][5][6][7][8][9][10][11]13,14 HIV infection, 8,[15][16][17][18][19][20][21] hematologic malignancy, [22][23][24] pregnancy, 25 and other conditions. MEDFs may be related to the altered immune status of these conditions, although the pathogenesis is uncertain.…”