Multiple Hox/HOM-Class Homeoboxes in Platyhelminthes

Bartels, Janet L.; Murtha, Michael T.; Ruddle, Frank H.

doi:10.1006/mpev.1993.1014

Cited by 48 publications

(15 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PCR amplification using degenerate primers has proven to be useful for identification of homeobox genes from various organisms (Bartels et al, 1993;Seimyia et al, 1994;Dick and Buss, 1994;Snow and Buss, 1994;Mito and Endo, 1997). Well-known limitations of this approach include the absence of exhaustivity and the difficulty of interpreting negative results, the shortness of recovered sequences, and the risk of contamination from other organisms.…”

Section: Discussionmentioning

confidence: 99%

Homeobox Gene Diversification in the Calcareous Sponge, Sycon raphanus

Manuel

Parco

2000

Molecular Phylogenetics and Evolution

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Homeobox Gene Diversification in the Calcareous Sponge, Sycon raphanus

Manuel

Parco

2000

Molecular Phylogenetics and Evolution

View full text Add to dashboard Cite

“…Using this method, previous studies revealed the existence and diversity of the Hox genes in a variety of animals, including sponges (Seimiya et al, 1994;Degnan et al, 1995), cnidarians (Schierwater et al, 1991), flatworms (Bartels et al, 1993), annelids (Dick and Buss, 1994;Snow and Buss, 1994), chelicerate arthropods (Cartwright et al, 1993), and primitive groups of chordates and a hemichordate (Pendleton et al, 1993). These pieces of evidence suggest that the Hox system is widely conserved through all metazoans.…”

Section: Introductionmentioning

confidence: 88%

“…In A-P patterning, Hox genes in a cluster are colinearly expressed, so that the nearer to the 38 end in a cluster a gene is located, the more anterior in the body the expression of the gene is limited. Based on such an expression pattern and sequence similarity of the homeodomain, cognate groups are divided into three groups, anterior (cognate groups 1-3), medial (cognate groups 4-8), and posterior (cognate groups 9-13) (Bartels et al, 1993). Understanding of such a fundamental system in a wide variety of taxa could provide insights into the evolution of body plan formation in Metazoa.…”

Section: Introductionmentioning

confidence: 99%

A PCR Survey of Hox Genes in the Sea Star,Asterina minor

Mito

Endo

1997

Molecular Phylogenetics and Evolution

View full text Add to dashboard Cite

“…The target sequences for primer set 5E/3F are homeoboxes in cognate groups 1-10. This primer set has been well tested on a variety of different organisms (Bartels et al, 1993;Cartwright et al, 1993;Dick & Buss, 1994;Murtha et al, 1991;Pendleton et al, 1993;Ledje et al, 2002).…”

Section: Genomic Dna Surveysmentioning

confidence: 99%

Evidence for independent Hox gene duplications in the hagfish lineage: a PCR-based gene inventory of Eptatretus stoutii

Stadler

Fried

Prohaska

et al. 2004

Molecular Phylogenetics and Evolution

Self Cite

View full text Add to dashboard Cite

Hox genes code for transcription factors that play a major role in the development of all animal phyla. In invertebrates these genes usually occur as tightly linked cluster, with a few exceptions where the clusters have been dissolved. Only in vertebrates multiple clusters have been demonstrated which arose by duplication from a single ancestral cluster. This history of Hox cluster duplications, in particular during the early elaboration of the vertebrate body plan, is still poorly understood. In this paper we report the results of a PCR survey on genomic DNA of the pacific hagfish Eptatretus stoutii. Hagfishes are one of two clades of recent jawless fishes that are an offshoot of the early radiation of jawless vertebrates. Our data provides evidence for at least 33 distinct Hox genes in the hagfish genome, which is most compatible Manuscript 24 October 2003with the hypothesis of multiple Hox clusters. The largest number, seven, of distinct homeobox fragments could be assigned to paralog group 9, which could imply that the hagfish has more than four clusters. Quartet mapping reveals that within each paralog group the hagfish sequences are statistically more closely related to gnathostome Hox genes than with either amphioxus or lamprey genes. These results support two assumptions about the history of Hox genes: (1) The association of hagfish homeobox sequences with gnathostome sequences suggests that at least one Hox cluster duplication event happened in the stem of vertebrates, i.e., prior to the most recent common ancestor of jawed and jawless vertebrates. (2) The high number of paralog group 9 sequences in hagfish and the phylogenetic position of hagfish suggests that the hagfish lineage underwent additional independent Hox cluster/-gene duplication events.

show abstract

Multiple Hox/HOM-Class Homeoboxes in Platyhelminthes

Cited by 48 publications

References 0 publications

Homeobox Gene Diversification in the Calcareous Sponge, Sycon raphanus

Homeobox Gene Diversification in the Calcareous Sponge, Sycon raphanus

A PCR Survey of Hox Genes in the Sea Star,Asterina minor

Evidence for independent Hox gene duplications in the hagfish lineage: a PCR-based gene inventory of Eptatretus stoutii

Contact Info

Product

Resources

About