Multiple Hepatic Adenomas Associated with Liver Steatosis at CT and MRI: A Case-Control Study

Furlan, Alessandro; Windt, Dirk J. van der; Nalesnik, Michael A.; Sholosh, Biatta; Ngan, Ka-Kei; Pealer, Karen; IJzermans, Jan N. M.; Federle, Michael P.

doi:10.2214/ajr.07.3419

Cited by 26 publications

(14 citation statements)

References 42 publications

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“…Another study [32] found that hepatic steatosis as measured by CT scan was present in 82% of patients with multiple HCAs as compared with 58% of patients with single HCA and 29% in a control group of patients with hemangioma. These series highlight the association between HCAs (in particular multiple HCAs) and steatosis and suggest potential factors that drive both steatosis and formation of HCAs.…”

Section: Introductionmentioning

confidence: 99%

Changing Epidemiology of Hepatocellular Adenoma in the United States: Review of the Literature

Chang

Hernández-Prera

Roayaie

et al. 2013

International Journal of Hepatology

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Hepatocellular adenoma (HCA) is a benign neoplasm arising from hepatocytes. There is evidence that the inflammatory subtype may be associated with obesity and alcohol use and that men with metabolic syndrome may be at risk for malignant transformation of HCA. We sought to explore the combined experience of US centers as reported in the literature to document the epidemiologic shift in risk factors for HCA formation in the United States, namely, a shift from oral contraceptive pills (OCPs) to an emerging role of obesity as a contributing factor. Methods. Publications reporting HCA in the United States were identified through a PubMed search and a review of the literature. We excluded publications prior to 1970, single case reports, and publications for which there was no data available regarding patient characteristics including OCP use and the number of adenomas. Conclusion. Whereas earlier reports of HCA in the United States described cases exclusively in women exposed to OCPs, there is a trend towards an increase in HCAs reported in men, HCAs in the absence of OCP use, and increased reporting of multiple HCAs. This may be a result of newer OCP formulations and increasing prevalence of obesity.

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Section: Introductionmentioning

confidence: 99%

Changing Epidemiology of Hepatocellular Adenoma in the United States: Review of the Literature

Chang

Hernández-Prera

Roayaie

et al. 2013

International Journal of Hepatology

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“…Recent studies reported a gender distribution in favour of female patients (74,75) and an association with OC use, glycogenosis, diabetes, high BMI, germline mutations of HNF-1a (L-FABP-negative HCA, a subgroup that seems to be associated with steatotis), non-alcoholic fatty liver disease and patients who undergo a Fontan procedure (8,10,35,74,76,77). Eighteen per cent of patients with LA showed steatosis in non-tumoural tissue which affects the management of patients with LA as liver steatosis has an impact on the outcome of liver surgery (75,78). Several other authors reported or suggested an increased incidence of multiple adenomas ( 2) in the setting of liver steatosis (11,62,77,78).…”

Section: Multiple Hepatocellular Adenoma and Liver Adenomatosismentioning

confidence: 99%

Can a decision‐making model be justified in the management of hepatocellular adenoma?

Aalten

Witjes

Man

et al. 2011

Liver International

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During recent years, there was a great development in the area of hepatocellular adenomas (HCA), especially regarding the pathological subtype classification, radiological imaging and management during pregnancy. This review discusses the current knowledge about diagnosis and treatment modalities of HCA and proposes a decision-making model for HCA. A Medline search of studies relevant to epidemiology, histopathology, complications, imaging and management of HCA lesions was undertaken. References from identified articles were hand-searched for further relevant articles.Radiological, as well as histological differentiation of hepatocellular adenoma (HCA) from other benign or malignant liver tumours, such as focal nodular hyperplasia (FNH) or hepatocellular carcinoma (HCC) might be difficult. However, once the diagnosis of HCA has been established, defining the right management strategy may be challenging as well. There are no randomized controlled studies available that depict a clear decision-making for the treatment of HCA in various conditions, and the management of individual patients depends mainly on the physicians or surgeons insight. The need for a clear decision-making is obvious as, for example, in case of young women in her childbearing age with multiple, bilateral or centrally located lesions and a need for pregnancy. As new imaging and treatment modalities have been developed during the last years, management of HCA has also developed sufficiently to warrant an update. In this manuscript, we review the current knowledge about diagnosis and treatment modalities of HCA, based on our own experience Liver International (2012)

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“…6 Hepatic adenomatosis can be seen in either sex with or without oral contraceptive use 5 ; other risk factors for adenoma include glycogen storage disease and hepatic steatosis. 7 In addition, adenoma formation may be associated with germ-line HNF1A (hepatocyte nuclear factor 1α) gene mutations. 5,8,9 Risk of complication in both HA and adenomatosis is related to the size of the largest lesion and underlying histopathological subtype.…”

Section: Introductionmentioning

confidence: 99%

Long-term follow-up of hepatic adenoma and adenomatosis: analysis of size change on imaging with histopathological correlation

et al. 2018

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Multiple Hepatic Adenomas Associated with Liver Steatosis at CT and MRI: A Case-Control Study

Abstract: Hepatic adenomas occur more frequently and more often are multiple in patients with hepatic steatosis.

Cited by 26 publications

References 42 publications

Changing Epidemiology of Hepatocellular Adenoma in the United States: Review of the Literature

Changing Epidemiology of Hepatocellular Adenoma in the United States: Review of the Literature

Can a decision‐making model be justified in the management of hepatocellular adenoma?

Long-term follow-up of hepatic adenoma and adenomatosis: analysis of size change on imaging with histopathological correlation

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