Multiple glomus tumors with a family history

Wb, Reed

doi:10.1001/archderm.100.4.496

Cited by 13 publications

(8 citation statements)

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“…The multiple glomus tumors usually occur in childhood or early adulthood 5 . There have been few reports of familial glomangioma 6–11 . An autosomal dominant form of inheritance has been suggested 7 and this would appear to be the case in the family reported here, with clear demonstration of glomangioma seen in three generations.…”

Section: Commentssupporting

confidence: 52%

Laser Treatment of Hereditary Multiple Glomus Tumors

Barnes

Estes

1986

The Journal of Dermatologic Surgery and Oncology

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Familial multiple glomus tumors are rare. A family is reported here with the disease documented in three generations. While this type of glomus tumor is not classically associated with pain, all members of this family who exhibited multiple glomangioma were symptomatic. Treatment with both the argon laser and carbon dioxide laser was successful in relieving symptoms and improving the appearance of only the more superficial glomus tumors.

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Section: Commentssupporting

confidence: 52%

Laser Treatment of Hereditary Multiple Glomus Tumors

Barnes

Estes

1986

The Journal of Dermatologic Surgery and Oncology

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“…When the vascular element proliferates, with the formation of large, irregular channels outlined by a thin mantle of glomus eells, lesions characteristic of the Multiple Glomus Tumor syndrome are seen. This form frequently is misdiagnosed as a simple cavernous hemangioma (Gorlin et al 1960, Hueston 1961, Reed 1969, Conant & Wiesenfeld 1971, Goodman 1972. Gorlin et al (1960) emphasized this by referring to these vaseular tumors as pseudocavernous hemangiomata.…”

Section: Glomus Tumorsmentioning

confidence: 99%

“…Multiple glomus tumors form a rare elinieal symptom complex inherited as an autosomal dominant trait (Kaufman & Clark 1941, Eyester & Montgomery 1960, Gorlin et aL I960,-Hueston 1961, Laymon & Peterson 1965, Reed 1969, Conant & Wiesenfeld 1971, HoUins 1971, Rycroft et al 1975. They are vascular tumors, thought to be derived from specialized arterio-venous anastomoses, ealled glomus bodies, located in the reticular dermis (Lever & Schaumberg-Lever 1975).…”

mentioning

confidence: 99%

Multiple Glomus Tumors

1977

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A man had widespread, slowly evolving vascular lesions since infancy suggestive of the Blue Rubber Bleb Nevus Syndrome. His son had two painless lesions typical of Multiple Glomus Tumors. Many of the man's nodular lesions were painful. Post-excision recurrences were noted. Histologic studies of asymptomatic tumors from both cases showed irregular, dilated, vascular channels surrounded by narrow mantles of glomus cells, whereas a painful tumor had large foci of glomus cells with wider mantles around the flattened channels. Electron microscopy showed the glomus cells to be modified smooth muscle cells. The anatomy and pathology of glomus tumors are reviewed. Differentiation from other syndromes of multiple hemangiomata, particularly the Blue Rubber Bleb Nevus Syndrome is stressed. It is suggested that Multiple Glomus Tumors may be derived from simple cutaneous vessels and not the Sucquet-Hoyer canal of the normal cutaneous glomus body described by Masson in 1924.

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“…6–8 Multifocality has been associated with children, familial inheritance, and pregnancy. 9–11 Multiple hereditary glomus tumors is a distinct, well-described entity and represents a subset of patients in whom multiple glomus tumors develop at a young age. Multiple hereditary glomus tumors are inherited in an autosomal dominant fashion through a glomulin gene mutation.…”

Section: Discussionmentioning

confidence: 99%

Glomus Tumors and Neurofibromatosis

Harrison

Sammer

2014

Plastic and Reconstructive Surgery Global Open

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Background:Glomus tumors are painful benign tumors arising from the neuromyoarterial elements of the glomus body, typically in a subungual location. Historically, glomus tumors have been considered isolated or sporadic, not typically associated with other disease processes. Over the last few years, however, multiple case reports, a molecular genetics study, and an epidemiologic study have confirmed an association between type I neurofibromatosis and glomus tumors. The purpose of this review is to summarize the existing information about the association between neurofibromatosis and glomus tumors and to determine whether glomus tumors that are associated with neurofibromatosis differ from isolated glomus tumors in terms of tumor number, location, and sex distribution.Methods:A PubMed, Ovid Medline, and Cochrane Database search was performed using the terms “glomus tumor,” “glomus tumour,” and “glomangioma” each combined with the search term “neurofibromatosis.” Fifteen English language articles were included. Information about the molecular genetics, patient sex, number of tumors per patient, and tumor location were recorded.Results:A total of 36 patients with glomus tumors and neurofibromatosis have been reported in the literature. Seventy-nine percent were female. Tumors were multifocal in 32% of patients, with an average of 1.4 glomus tumors per patient. Glomus tumors arose in a nonsubungual location in 38% of patients.Conclusions:A strong association between type I neurofibromatosis and glomus tumors has been identified. In neurofibromatosis patients with glomus tumors, the sex distribution, tumor location, and tumor burden appear similar to those in patients with isolated glomus tumors. Treating providers should be aware of this association to facilitate prompt diagnosis and treatment.

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Multiple glomus tumors with a family history

Cited by 13 publications

References 0 publications

Laser Treatment of Hereditary Multiple Glomus Tumors

Laser Treatment of Hereditary Multiple Glomus Tumors

Multiple Glomus Tumors

Glomus Tumors and Neurofibromatosis

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