Multiple Giant Cell Tumors of Tendon Sheath Found within a Single Digit of a 9-Year-Old

Hwang, John S.; Fitzhugh, Valerie A.; Gibson, Peter; Didesch, Jacob; Ahmed, Irfan

doi:10.1155/2016/1834740

Cited by 10 publications

(22 citation statements)

References 6 publications

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“…[ 7 , 12 ] GCT-TS is also termed tenosynovial giant cell tumor, pigmented nodular tenosynovitis, xanthogranuloma, benign synovioma, and fibrous xanthoma of synovium. [ 2 , 13 , 14 ] The GCT-TS is a benign but locally aggressive tumor that arises from the synovial membrane of joints, tendon sheaths, and bursae. [ 14 ] Although any joint can be affected, involvement of the TMJ was reported very rarely.…”

Section: Discussionmentioning

confidence: 99%

Diffuse giant cell tumors of the tendon sheath in temporomandibular joint

HONG¹,

Wang²,

Lin³

et al. 2018

Medicine

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Rationale:Diffuse giant cell tumors of the tendon sheath (GCT-TS) in the temporomandibular joint (TMJ) are extremely rare.Patient concerns:We reported the imaging appearance and the pathological findings of 2 male cases with diffuse GCT-TS in the TMJ (52 years for the case 1 and 50 years for the case 2) who complain of the hearing disorders of left ear when presenting to our hospital.Diagnosis:Preoperative computerized tomography (CT) scan revealed an irregular mass in the left temporal fossa with the sizes of approximately 5.8 × 3.8 × 4.6 cm for case 1 and 4.2 × 3.2 × 4.3 cm for case 2, respectively. Magnetic resonance imaging (MRI) findings showed a mass of 6.1 × 4.0 × 5.1 cm and 5.3 × 3.6 × 3.3 cm, respectively. Postoperative pathological examination revealed the diffuse multinucleated giant cells accompanied with synovial cells in the diffuse arrangement. Immunohistochemical examination showed CD68 (+), Vim (+), S-100 (-) and 2% of Ki-67 proliferation index. These characteristics are in line with the diagnosis of the diffuse GCT-TS in the TMJ.Interventions:Both cases underwent the gross total resection followed by radiation therapy.Outcomes:Two patients experienced no recurrence after follow-up of 1 to 2 year(s).Lessons:Diffuse GCT-TS in the TMJ is very rare. Clinicians should keep in mind the possibility of the GCT-TS when aggressive lesions involve the TMJ and adjacent bone destruction was found. Careful pre- and postoperative examinations and complete resection are the factors that lead to its optimal treatment, significantly reducing its recurrence rate.

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Section: Discussionmentioning

confidence: 99%

Diffuse giant cell tumors of the tendon sheath in temporomandibular joint

HONG¹,

Wang²,

Lin³

et al. 2018

Medicine

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“…Localized form is benign and involve the hand and fingers, while diffuse form is more aggressive and occurs in large joints [ 3 ]. GCTTS typically occurs near the distal interphalangeal joint of the index or long finger of the hand [ 4 ]. (see Fig.…”

Section: Introductionmentioning

confidence: 99%

Giant cell tumor of tendon sheath at the hand: A case report and literature review

Liu

2020

Annals of Medicine and Surgery

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Introduction GCTTS is the second most popular soft tissue tumor at the hand next to ganglion cyst, and also named tenosynovial giant cell tumor or pigmented villonodular tenosynovitis. It is divided into localized form and diffuse form. We introduce a report of a rare case of GCTTS in a female where lesions were identiied within the left ring finger and also conducted a literature review. Presentation of case We describe a 32-year-old female patient with GCTTS a single digit since six months. Radiographic and histopathological examination is necessary to help determine whether to take further treatment. Surgical excision was performed, including complete removal of the tumor and reconstruction of the pulley with autologous tendon. Histopathology suggested that these masses were consistent with GCTTS without malignancy. There was no clinical and radiologic evidence of recurrence six months after surgery. Discussion GCTTS is a benign fibrous tissue tumor originating from the tenosynosheath, bursae and joint synovium. This tumor is more common in adults aged 30–50, and is slanted toward females. The major risk of GCTTS is recurrence and joint damage, which requires surgical resection. The integrity of the pulley plays an important role in the function of the hand. In this case, the ipsilateral metacarpal tendon was taken during the operation to reconstruct the pulley to reduce the possibility of loss of hand function. Conclusion This case represents a rare case of GCTTS at the hand within a single digit. Due to its high recurrence rate, the tumor should be completely removed to reduce the possibility of recurrence. Radiographic and histopathological examination must be performed on the tumor, which is determined to be benign and does not require further treatment. The function of the hand should be reconstructed to minimize the loss if necessary.

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“…Giant-cell tumor of the tendon sheath is considered the most frequent hand tumor, and it results from a benign proliferation of histiocytes from the joints and peritendinous synovial tissues developing around the tendon sheaths, joint ligaments and joint synovium. 4 12 13 14 15 16 Although there is still some divergence among the researchers, the most accepted etiology is reactive or regenerative hyperplasia associated with inflammation. 5 17 …”

Section: Introductionmentioning

confidence: 99%

“…Giant-cell tumor of the tendon sheath is more common between the ages of 30 and 50 years, with a female predominance in a ratio of approximately 3:2. 2 3 8 13 14 17 18 It mostly occurs as tumor growths in the hands, mainly in the radial fingers, frequently close to the distal interphalangeal joint. 3 7 8 14 18 19 The tumor favors the flexor aspect of the hand, although the extensor aspect can also be affected.…”

Section: Introductionmentioning

confidence: 99%

Estudo retrospectivo dos resultados do tratamento cirúrgico de 31 tumores de células gigantes da bainha do tendão da mão

et al. 2019

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ResumoAvaliar os resultados do tratamento de 31 tumores de células gigantes da bainha do tendão da mão encontrados entre 2006 e 2015.Entre fevereiro de 2006 e novembro de 2015, um grupo de pacientes foi selecionado para avaliação retrospectiva, na qual foram estudados e avaliados 31 prontuários de pacientes submetidos a procedimento cirúrgico devido a tumor de células gigantes da bainha do tendão dos dedos da mão. O tratamento preconizado foi a excisão completa do tumor com a preservação das estruturas adjacentes. A confirmação diagnóstica foi feita pelo exame anatomopatológico. Foi avaliada a evolução do tratamento após a cirurgia, principalmente no tocante ao índice de recidivas dos tumores.Dos 31 pacientes da amostra, houve predomínio do sexo feminino e da etnia branca. O tumor acometeu principalmente indivíduos entre 30 e 50 anos. O lado mais acometido foi o esquerdo, e a maioria dos tumores estava na face flexora. Houve predominância dos dedos radiais, juntamente com sua extremidade distal. Esses pacientes têm sido acompanhados em intervalos regulares em ambulatório. Dos 27 pacientes reavaliados, foram identificados 3 casos de recidiva tumoral.Uma técnica cirúrgica adequada é essencial para a prevenção de recidivas do TCGBT. Os resultados obtidos na pesquisa estão em concordância com a literatura atual.

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Multiple Giant Cell Tumors of Tendon Sheath Found within a Single Digit of a 9-Year-Old

Cited by 10 publications

References 6 publications

Diffuse giant cell tumors of the tendon sheath in temporomandibular joint

Diffuse giant cell tumors of the tendon sheath in temporomandibular joint

Giant cell tumor of tendon sheath at the hand: A case report and literature review

Estudo retrospectivo dos resultados do tratamento cirúrgico de 31 tumores de células gigantes da bainha do tendão da mão

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