Multiple Eruptive Angiomatous Lesions in a Patient With Multiple Myeloma—Quiz Case

Ferrán, Marta; Giménez‐Arnau, Ana

doi:10.1001/archderm.142.11.1501-d

Cited by 12 publications

(8 citation statements)

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“…25 This immunophenotype suggests that MVH is a reactive/reparative process despite the absence of reported causative agent or trigger coinciding with the onset of MVH. The occurrence of multiple and eruptive MVH supports this supposition as other vascular and vascular-like tumors can present as agminated or eruptive lesions, including lobular capillary hemangioma, 26 capillary (cherry) hemangioma, 27 tufted angioma, 28 glomeruloid hemangioma, 29 bacillary angiomatosis, 30 and pseudoangiomatosis. 31 Like our case of MVH, most of these vascular tumors have been shown to express the Wilms tumor 1 antigen, confirming their proliferative (reactive or neoplastic) nature.…”

Section: Discussionmentioning

confidence: 68%

Microvenular Hemangioma Presenting With Numerous Bilateral Macules, Patches, and Plaques

Linos

Csaposs²

2013

The American Journal of Dermatopathology

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Microvenular hemangioma (MVH) is a rare, slowly growing, benign vascular tumor that typically presents as a solitary enlarging plaque or nodule on the trunk or the extremities of young to middle-aged adults. A minority of MVH present with multiple lesions that are either gradually or suddenly acquired (eruptive MVH). Herein, we report a case of a 53-year-old woman who progressively developed numerous bilateral MVHs presenting as enlarging, blanching, erythematous to violaceous macules, patches, and plaques over the proximal thighs and axillae. Two biopsies exhibited the irregular branching venules with inconspicuous lumina lacking endothelial atypia and associated with dermal fibrosis characteristic of MVH. Immunophenotypically, the endothelium expressed Wilms Tumor 1, CD31, CD34, and erythrocyte-type glucose transporter protein (GLUT-1) GLUT-1 focally and was negative for Human herpes virus 8 and the lymphatic marker D2-40. In addition, numerous dermal spindle cells expressing CD34 and procollagen, putative fibrocytes, surrounded the thickened dermal collagen bundles and small vessels of MVH implicating a reactive/reparative (proliferative) process due to an unrecognized cutaneous injury. A review of MVH summarizing its clinicopathologic findings and its natural history is presented.

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Section: Discussionmentioning

confidence: 68%

Microvenular Hemangioma Presenting With Numerous Bilateral Macules, Patches, and Plaques

Linos

Csaposs²

2013

The American Journal of Dermatopathology

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“…Some studies suggested CA induction by chemicals, immunosuppression by cyclosporine, and chronic graft‐versus‐host disease . CAs have been documented to occur with lymphoproliferative diseases . An involvement of specific miRNA has been shown in CA induction .…”

Section: The Study Variables In the Enrolled Populationmentioning

confidence: 99%

Predisposing factors for eruptive cherry angiomas: New insights from an observational study

Borghi

Minghetti

Battaglia³

et al. 2016

Int J Dermatology

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“…Glomeruloid haemangioma is a unique abnormality among POEMS syndrome‐associated skin changes and observed in 9–35% of patients presenting as multiple red‐purple lesions on the trunk and proximal limbs; however, this lesion is rarely reported in patients without POEMS syndrome (Chan et al , ; Ferran & Gimenez‐Arnau, ; Chung et al , ). Thus, accurate identification of haemangioma may facilitate a more rapid diagnosis.…”

Section: Diagnosismentioning

confidence: 99%

New advances in the diagnosis and treatment of POEMS syndrome

Zhou

2013

Br J Haematol

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SummaryPOEMS syndrome is a clonal plasma cell disease characterized by polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes. Significant advances have been made in the diagnosis and treatment of POEMS syndrome over the last decade. Herein, the diagnostic criteria and characteristic features are reviewed, focusing the role of characteristic features in early diagnoses. Autologous peripheral blood stem cell transplantation has become the first-line treatment for younger patients with normal organ function. Autologous transplantation has resulted in a high response rate and durable remission. Moreover, transplantation-related morbidity and mortality has been significantly reduced over the past 5 years. Induction therapy before transplantation may improve the harvest of stem cells and decrease transplantation-related morbidity. Melphalan and dexamethasone is an effective and well-tolerated treatment for older patients or those with organ dysfunction. Novel agents may also offer benefits to patients with a poor performance status or renal dysfunction, and transform transplantation eligibility.

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Multiple Eruptive Angiomatous Lesions in a Patient With Multiple Myeloma—Quiz Case

Cited by 12 publications

References 0 publications

Microvenular Hemangioma Presenting With Numerous Bilateral Macules, Patches, and Plaques

Microvenular Hemangioma Presenting With Numerous Bilateral Macules, Patches, and Plaques

Predisposing factors for eruptive cherry angiomas: New insights from an observational study

New advances in the diagnosis and treatment of POEMS syndrome

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