Multiple cutaneous plexiform schwannomas with tumors of the central nervous system

Rongioletti, Franco

doi:10.1001/archderm.125.3.431

Cited by 12 publications

(16 citation statements)

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“…Only 5% of schwannomas develop into the plexiform type and these are usually seen as solitary or multiple lesions affecting young adults (Rongioletti et al, 1989). They are usually found on the trunk, head and neck or the extremities as slowly growing, asymptomatic, well circumscribed lesions.…”

Section: Discussionmentioning

confidence: 99%

Multiple Plexiform Schwannoma of the Hand and Forearm: A Long-Term Follow-Up

Talwalkar

Cutler

Stilwell

2005

Journal of Hand Surgery

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We present a case report to illustrate the differential diagnosis and management of a multiple plexiform schwannoma involving the main nerve trunks of the upper limb in a 4 year-old boy. The tumour was diagnosed by MRI scan and histological examination. A 12 year follow-up is presented in which, despite multiple recurrences, the condition has been controlled by surgical means and the limb salvaged.

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Section: Discussionmentioning

confidence: 99%

Multiple Plexiform Schwannoma of the Hand and Forearm: A Long-Term Follow-Up

Talwalkar

Cutler

Stilwell

2005

Journal of Hand Surgery

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“…6,9 Most multiple plexiform schwannomas were located in diffuse anatomical sites, 6,9 but localized multiple lesions were also reported. 10 Our patient had multiple plexiform schwannomas localized in the small intestine, the macroscopic appearance of which differed from the previously reported visceral case, which was a solitary lesion in the colon.…”

Section: Discussionmentioning

confidence: 99%

“…[3][4][5][6][7][8][9][10][11][12] To our knowledge, there is only one case report of plexiform schwannoma originating in the colon, 3 and we describe herein the first known case of plexiform schwannoma of the small intestine. …”

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confidence: 99%

Plexiform Schwannoma of the Small Intestine: Report of a Case

et al. 2003

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Plexiform schwannoma is a benign peripheral nerve sheath tumor composed exclusively of schwann cells arranged in a plexiform pattern. Most plexiform schwannomas are skin tumors and there has been only one case report of this tumor originating in the colon. We describe herein the first known case of plexiform schwannoma of the small intestine occurring without any relationship to schwannomatosis or neurofibromatosis. A 57-year-old man presented with a short history of abdominal pain, vomiting, and bloody stool after each meal. Jejunography demonstrated multiple nodular tumors in the small intestine. We resected the small intestine laparoscopically. The tumors consisted of multiple white nodules in the submucosal and subserosal layers. Microscopic examination revealed that each tumor was composed mainly of Antony A tissue, compatible with conventional schwannoma. Immunohistochemically, the tumors were positive for S-100, vimentin, and neuron-specific enolase, and negative for HHF35, Alpha-SMA, and c-kit. No evidence of recurrence has been found in 38 months of follow-up.

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“…Less commonly, the tumour may present as a neuropathy [5,9]. Multiple cutaneous neurilemmonas, especially when plexiform in nature, may be a marker of neural tumours in the internal organs [8].…”

Section: Case Reportmentioning

confidence: 99%