Multiple cutaneous neuromas

Unusual presentation of multiple palisaded encapsulated neuromas

“…Although PEN usually occurs as a solitary lesion, multiple lesions, as in the present case, have been referenced in at least six previous reports 4–9 . Albeit that PEN is a so‐called solitary circumscribed neuroma (SCN), 11 SCN does not appear to be an appropriate description in cases involving multiple lesions.…”

“…Acral involvement has rarely been reported in association with this condition 2,3 . Multiple lesions have seldom been described 4–9 . Herein, we report a case of multiple PENs on the face, neck, and hands.…”

Mucocutaneous Neuromas

“…50,69,[74][75][76][77][78][79][80][81][82][83] At least 6 patients had cutaneous and mucosal lesions, 50,74,76,77,81,82 and 11 patients were noted to have prominent corneal nerves. 50,74,[77][78][79][80]82 In 4 affected families, genetic analysis confirmed the absence of mutations in the RET protooncogene.…”

Involvement of the Nerve Fibers in the Human Skin Neurofibromatosis

“…Microscopical study of these spots shows melanocyte with giant melanosomas, circular bodies of 500 Angstrom in diameter, freckles and scattered freckles, white nevi [5]. Moreover in skin neurofibromas Schochet and Barret [6] demonstrated the presence of aberrant tactile corpuscles.…”

“…Pennelli and Stoppelli demonstrated some anatomo-clinical aspects of vesicle neurofibromatosis [4]. Holm and coworkers first studied multiple cutaneous neuromas showing that the skin lesions are formed by the typical coffee and milk spots, pathognomonic of the disease [5]. When they are six or more and with a diameter of 1.5 cm (already found at the birth or during the first year of life).…”