Multiple cutaneous metastases in a patient of carcinoma tonsil – Report of a rare case

Singh, Gunjesh Kumar; Yadav, Vikas; Singh, Pragya; Bhowmik, K.T.

doi:10.1016/j.jnci.2016.04.004

Cited by 6 publications

(39 citation statements)

References 11 publications

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“…The most common type is squamous cell carcinoma (75%), while lymphoma accounts for the majority of the remaining cases [6]. Cutaneous metastases from tonsillar squamous cell carcinoma are rare; to the best of our knowledge, including our patient, only four patients have been described in the literature (Table 1) [3-5]. Notably, all four individuals were men.…”

Section: Discussionmentioning

confidence: 97%

“…The third patient with cutaneous metastasis from tonsillar squamous cell carcinoma was reported in 2016 [3]. A 55-year-old man with a history of smoking presented with dysphagia, throat pain, and weight loss for three months.…”

Section: Discussionmentioning

confidence: 99%

“…Biopsy of the skin lesions demonstrated squamous cell carcinoma. The patient received palliative treatment with methotrexate [3]. …”

Section: Discussionmentioning

confidence: 99%

“…A retrospective review of 4,020 patients with metastatic cancer revealed that 10% of the patients developed cutaneous metastases; the most common malignancies manifesting with cutaneous metastases were breast cancer and melanoma [2]. Squamous cell carcinoma of the tonsil, which represents 10% of head and neck malignancies, may also manifest with cutaneous metastases [3]. However, only three prior cases of cutaneous metastases secondary to this malignancy have been reported to date [3-5].…”

Section: Introductionmentioning

confidence: 99%

“…Squamous cell carcinoma of the tonsil, which represents 10% of head and neck malignancies, may also manifest with cutaneous metastases [3]. However, only three prior cases of cutaneous metastases secondary to this malignancy have been reported to date [3-5]. Biopsy is warranted when there is suspicion for cutaneous metastasis, since spread of the visceral tumor to the skin is usually a poor prognostic marker [1, 4].…”

Section: Introductionmentioning

confidence: 99%

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Cutaneous Metastasis From Tonsillar Squamous Cell Carcinoma: Report and Review of the Literature

Bari

Cohen

2017

Cureus

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Tonsillar squamous cell carcinoma, which represents 10% of head and neck malignancies, rarely manifests with cutaneous metastases; to date, only three prior patients with tonsillar squamous cell carcinoma have been reported to develop cutaneous metastases. We describe the clinical features of a 59-year-old man with squamous cell carcinoma of the tonsil who developed cutaneous metastases within his prior radiation port and review the literature of prior patients with cutaneous metastases from tonsillar squamous cell carcinoma. The PubMed database was searched for the following keywords: carcinoma, cutaneous, metastasis, squamous, and tonsil. The papers generated by the search and their references were reviewed. Cutaneous metastasis from tonsillar cancer is rare but should be considered in patients with a history of a squamous cell carcinoma of the tonsil; new skin lesions, both overlying the visceral malignancy and at more distant sites, should be biopsied since prognosis in these patients is poor. Management has thus far been palliative and should be individualized to the patient.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

“…Biopsy of the skin lesions demonstrated squamous cell carcinoma. The patient received palliative treatment with methotrexate [3]. …”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cutaneous Metastasis From Tonsillar Squamous Cell Carcinoma: Report and Review of the Literature

Bari

Cohen

2017

Cureus

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Cutaneous metastasis of tonsillar carcinoma: Report of a rare case

et al. 2018

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Metastatic Tonsil Squamous Cell Carcinoma: An Important Consideration in the Differential Diagnosis of Malignant Basaloid Neoplasms in the Skin: Case Report and Review of the Literature

Thigpen,

Johnston,

Giubellino

et al. 2024

The American Journal of Dermatopathology

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Malignant basaloid neoplasms of the skin are frequent, and their accurate diagnosis holds paramount importance for treatment and prognosis. However, these neoplasms can present diagnostic challenges because of their extensive differential diagnosis, which encompasses cutaneous metastasis among many other possibilities. We present a case of a 74-year-old man with a history of p16-positive palatine tonsil squamous cell carcinoma (SCC) treated with surgery and adjuvant radiation with no prior evidence of recurrence who presented to the dermatologist with 2 chin papules. The initial histopathologic evaluation of these lesions showed poorly differentiated malignant basaloid neoplasms. Subsequently, these biopsies were compared with the previous biopsies from his tonsil and lymph node, which showed similar findings including positive p16 staining and positive molecular testing for human papillomavirus-16, confirming the diagnosis of cutaneous metastasis from his previously diagnosed human papillomavirus–related tonsil SCC. Additional imaging studies found metastases to internal organs including the brain, and he was started on chemotherapy, immunotherapy, and radiation therapy. Cutaneous metastases from tonsil SCC are exceedingly rare, and only 5 cases have been described. Furthermore, this is the first case confirming the presence of high-risk human papillomavirus by molecular studies within the cutaneous metastases. The presented case underscores the importance of recognizing this unusual manifestation of tonsil SCC metastatic to the skin along with a good clinical patient history, ensuring accurate and prompt diagnosis and treatment of this condition.

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Multiple cutaneous metastases in a patient of carcinoma tonsil – Report of a rare case

Cited by 6 publications

References 11 publications

Cutaneous Metastasis From Tonsillar Squamous Cell Carcinoma: Report and Review of the Literature

Cutaneous Metastasis From Tonsillar Squamous Cell Carcinoma: Report and Review of the Literature

Cutaneous metastasis of tonsillar carcinoma: Report of a rare case

Metastatic Tonsil Squamous Cell Carcinoma: An Important Consideration in the Differential Diagnosis of Malignant Basaloid Neoplasms in the Skin: Case Report and Review of the Literature

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