Multiple clear-cell acanthoma and ichthyosis

Pale (Clear) Cell Acanthoma of the Palate

“…Interestingly, CCA shares similar immunohistochemical characteristics of cytokeratin expression with psoriasis, lichen planus and discoid lupus erythematosus [15,25]. Furthermore, cases of CCA are frequently reported in association with active plaque-type psoriasis [22], ichthyosis [23] seborrheic keratosis [24] and stasis, atopic or bacterial dermatitis [15,21]. Potenziani et al [12] reported multiple CCAs in a 63-year-old male patient with Cowden syndrome.…”

Clear (pale) cell acanthosis as an incidental finding

“…25,26 Both may also be seen adjacent to atypical nevi. 21 Thus far, it does not seem that clear (pale) cell acanthosis is present in multiple genital lesions, but it may be increased 6,13,14,à Clear (pale) cell acanthoma [1][2][3][4][5] Multiple clear (pale) cell acanthomas 11,15 : unknown Psoriasiform Psoriasiform keratosis 36,37 Psoriasis: multifactorial, PSORS1/2 Granular parakeratosis à Granular parakeratotic acanthoma 38 (Axillary) Granular parakeratosis: possibly secondary to decreased conversion of profilaggrin to filaggrin BCIE, bullous congenital ichthyosiform erythroderma; dsg3, desmoglein 3; EV, epidermodysplasia verruciformis; HPV, human papilloma virus. à This has been described as an incidental finding.…”

Urachal duct remnant‐like umbilical clear cell acanthoma in an infant: An unusual presentation and pitfall in clinical practice

“…[9][10][11] Several clinical variants of CCA exist. 7,[12][13][14][15][16][17][18][19] Atypical locations, such as the buttock, 17 suprapubic 14 and vermilion mucosa, 20 have also been described. However, infantile clear cell acanthomas have never been reported in the English literature and can easily be confused with the differential diagnoses of umbilical nodules if they occurred on the umbilicus, as was the case with this patient.…”

“…Erythematous surface with a clear sweaty discharge or serous exudate are frequently noted 9–11 . Several clinical variants of CCA exist 7,12–19 . Atypical locations, such as the buttock, 17 suprapubic 14 and vermilion mucosa, 20 have also been described.…”

“…Landry et al. speculated that neoplastic epidermal cells lose their enzymatic properties, stored glycogen, and have increased numbers of dendritic cells and leukerocytes 19 . However, more and more CCAs have been found in areas of preexisting inflammatory dermatosis, such as varicose dermatitis, stasis dermatitis, bacterial infection, psoriatic plaques, 21,24 trauma on scars and insect bites 8 .…”