Multiple chikungunya virus introductions in Lao PDR from 2014 to 2020

Calvez, Elodie; Bounmany, Phaithong; Somlor, Somphavanh; Xaybounsou, Thonglakhone; Viengphouthong, Souksakhone; Keosenhom, Sitsana; Brey, Paul T.; Lacoste, Vincent; Grandadam, Marc

doi:10.1371/journal.pone.0271439

Cited by 5 publications

(7 citation statements)

References 41 publications

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“…The E2-L248F from clade I has been reported in Asian lineage sequences from Colombia (2014-2015) and Philippines (2012) 45,46 . Isolates from Thailand, Indonesia, Lao PDR, Cameroon and India also presented the 6K-I54V mutation observed in clade I 44,[47][48][49][50] .…”

Section: Discussionmentioning

confidence: 92%

Increased interregional virus exchange and nucleotide diversity outline the expansion of the chikungunya virus ECSA lineage in Brazil

Xavier

Alcântara

Fonseca

et al. 2023

Preprint

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The emergence and reemergence of mosquito-borne diseases in Brazil such as Yellow Fever, Zika, Chikungunya, and Dengue have had serious impacts on public health. Concerns have been raised due to the rapid dissemination of the chikungunya virus (CHIKV) across the country since its first detection in 2014 in Northeast Brazil. Faced with this scenario, on-site training activities in genomic surveillance carried out in partnership with the National Network of Public Health Laboratories have led to the generation of 422 CHIKV genomes from 12 Brazilian states over the past two years (2021-2022), a period that has seen more than 312 thousand chikungunya fever cases reported in the country. These new genomes increased the amount of available data and allowed a more comprehensive characterization of the dispersion dynamics of the CHIKV East-Central-South-African (ECSA) lineage in Brazil. Tree branching patterns revealed the emergence and expansion of two distinct subclades. Phylogeographic analysis indicated that the northeast region has been the leading hub of virus spread towards other regions. Increased frequency of C>T transitions among the new genomes suggested that host restriction factors from the immune system such as ADAR and AID/APOBEC deaminases might be driving CHIKV ECSA lineage genetic diversity in Brazil.

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Section: Discussionmentioning

confidence: 92%

Increased interregional virus exchange and nucleotide diversity outline the expansion of the chikungunya virus ECSA lineage in Brazil

Xavier

Alcântara

Fonseca

et al. 2023

Preprint

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“…albopictus [ 31 ]. In our study, both strains presented this mutation in their genome [ 23 , 30 ]. However, in laboratory conditions, our results demonstrated low transmission efficiencies for both CHIKV strains.…”

Section: Discussionmentioning

confidence: 99%

“…In Lao PDR, only one CHIKV outbreak was recorded and it was limited to the Champasak province in 2012–2013 [ 23 ]. Since then, four imported cases of CHIKV were recorded in Vientiane capital from French Polynesia, Indonesia, Myanmar, and Thailand between 2014 and 2020 without the detection of local circulation in this province [ 30 ]. Even if no autochthonous CHIKV cases were detected after the detection of these imported cases, this demonstrated the risk of CHIKV introduction in the country due to presence of the potential vectors Ae.…”

Section: Discussionmentioning

confidence: 99%

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Low Transmission of Chikungunya Virus by Aedes aegypti from Vientiane Capital, Lao PDR

Calvez

Miot

Keosenhom³

et al. 2022

Pathogens

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In 2012–2013, chikungunya virus (CHIKV) was the cause of a major outbreak in the southern part of Lao People’s Democratic Republic (Lao PDR). Since then, only a few imported cases, with isolates belonging to different lineages, were recorded between 2014 and 2020 in Vientiane capital and few autochthonous cases of ECSA-IOL lineage were detected in the south of the country in 2020. The CHIKV epidemiological profile contrasts with the continuous and intensive circulation of dengue virus in the country, especially in Vientiane capital. The study’s aim was to investigate the ability of the local field-derived Aedes aegypti population from Vientiane capital to transmit the Asian and ECSA-IOL lineages of CHIKV. Our results revealed that, for both CHIKV lineages, infection rates were low and dissemination rates were high. The transmission rates and efficiencies evidenced a low vector competence for the CHIKV tested. Although this population of Ae. aegypti showed a relatively modest vector competence for these two CHIKV lineages, several other factors could influence arbovirus emergence such as the longevity and density of female mosquitoes. Due to the active circulation of CHIKV in Southeast Asia, investigations on these factors should be done to prevent the risk of CHIKV emergence and spread in Lao PDR and neighboring countries.

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“…Indonesia has been the most affected country ( 25 ), followed by Thailand ( 15 ), Malaysia ( 14 , 88 ), the Philippines ( 88–90 ), Cambodia ( 31 , 91 ), and Singapore ( 92 ). While Myanmar ( 17 , 93 ), and Lao PDR ( 20 , 94 ) reported minor outbreaks or sporadic cases, and no available data are available for Vietnam, Brunei and Timor-Leste (the number of cases of the two largest outbreaks per country is reported in Figure 3 ). However, the true burden of CHIKV virus disease remains unknown.…”

Section: Epidemiology Of Emerging and Re-emerging Viral Zoonoses In S...mentioning

confidence: 99%

Emerging and re-emerging zoonotic viral diseases in Southeast Asia: One Health challenge

Saba Villarroel,

Gumpangseth,

Songhong

et al. 2023

Front. Public Health

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The ongoing significant social, environmental, and economic changes in Southeast Asia (SEA) make the region highly vulnerable to the emergence and re-emergence of zoonotic viral diseases. In the last century, SEA has faced major viral outbreaks with great health and economic impact, including Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), arboviruses, highly pathogenic avian influenza (H5N1), and Severe Acute Respiratory Syndrome (SARS-CoV); and so far, imported cases of Middle East Respiratory Syndrome Coronavirus (MERS-CoV). Given the recent challenging experiences in addressing emerging zoonotic diseases, it is necessary to redouble efforts to effectively implement the “One Health” initiative in the region, which aims to strengthen the human-animal–plant-environment interface to better prevent, detect and respond to health threats while promoting sustainable development. This review provides an overview of important emerging and re-emerging zoonotic viral diseases in SEA, with emphasis on the main drivers behind their emergency, the epidemiological situation from January 2000 to October 2022, and the importance of One Health to promote improved intervention strategies.

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Multiple chikungunya virus introductions in Lao PDR from 2014 to 2020

Cited by 5 publications

References 41 publications

Increased interregional virus exchange and nucleotide diversity outline the expansion of the chikungunya virus ECSA lineage in Brazil

Increased interregional virus exchange and nucleotide diversity outline the expansion of the chikungunya virus ECSA lineage in Brazil

Low Transmission of Chikungunya Virus by Aedes aegypti from Vientiane Capital, Lao PDR

Emerging and re-emerging zoonotic viral diseases in Southeast Asia: One Health challenge

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