Multiple anthelmintic resistance and the possible contributory factors in Beetal goats in an irrigated area (Pakistan)

Saeed, Muhammad; Iqbal, Zafar; Jabbar, Abdul; Masood, Shahid; Babar, Wasim; Saddiqi, H.A.; Yaseen, Muhammad; Sarwar, M.; Arshad, Muhammad Imran

doi:10.1016/j.rvsc.2009.08.004

Cited by 20 publications

(18 citation statements)

References 29 publications

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“…Embora ambos os estudos tenham ocorrido em rebanhos na região nordeste, deve-se considerar que a taxa de desenvolvimento da resistência aos anti-helmínticos varia geograficamente (Leignel & Humbert 2001, Saeed et al 2010), na dependência de vários fatores incluindo o número de tratamentos, o uso repetido de um mesmo grupo químico (Silvestre et al 2002) e a época do tratamento. Em relação a este último, Melo et al (2009) salientaram que as dosificações anti-helmínticas no período seco podem acelerar o desenvolvimento da resistência na região semiárida do nordeste brasileiro, pois este período é caracterizado por uma população em refúgio pequena ou nula.…”

Section: Discussionunclassified

Resistência anti-helmíntica em rebanhos caprinos nos biomas Caatinga e Mata Atlântica

et al. 2015

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RESUMO.-A utilização de anti-helmínticos por longos períodos como principal medida de controle das parasitoses gastrintestinais de ruminantes levou a ineficácia aos levamisol, benzimidazóis e avermectinas. Este estudo descreve a atividade anti-helmíntica in vivo em populações naturais de nematoides trichostrongilídeos de caprinos. Foram selecionados 18 rebanhos provenientes dos biomas Caatinga (n=12) e Mata Atlântica (n=6), do Estado da Bahia, Brasil, criados em pastagens comunais em região semiárida. Grupos de oito a 10 animais foram tratados com albendazol (ABZ), ivermectina (IVM), levamisol (LEV), moxidectina (MOX) e closantel (CLOS). Os resultados do Teste de Redução da Contagem de Ovos nas Fezes indicaram resistência simultânea dos gêneros Haemonchus sp. e Trichostrongylus spp. para o ABZ, IVM, LEV, MOX e CLOS. As percentagens de eficácia variaram de 0-92%, 0-75%, 0-91%, 69-97% e 0-85% para o ABZ, IVM, LEV, MXD e CLOS, respectivamente, no bioma Caatinga e 0-59% para o ABZ e 9-59% para o IVM no bioma Mata Atlântica. Verificou-se nos rebanhos eficácia inferior a 95% para estes anti-helmínticos, com exceção de um único rebanho no qual a eficácia para MOX foi de 97%, o que sugere a presença de NGIs resistentes aos principais classes de anti-helmínticos em rebanhos caprinos destes biomas. The use of anthelmintic drugs for long periods as the main measure control of gastrointestinal nematodes (GINs) has led to the inefficacy of levamisole, benzimidazoles and macrocyclic lactones. This study describes the in vivo anthelmintic activity against natural trichostrongyle nematodes populations in goats. We selected 18 herds from the Caatinga (n=12) and Mata Atlântica (n=6) biomes, Bahia State, Brazil, raised in communal pastures in semiarid region. Groups of 8 to 10 goats were treated with albendazole (ABZ), ivermectin (IVM), levamisole (LEV), moxidectin (MOX), and closantel (CLOS). The results of the Fecal Egg Count Reduction Test indicated simultaneous resistance of Haemonchus sp. and Trichostrongylus spp. genera against albendazole (ABZ), ivermectin (IVM), levamisole (LEV), moxidectin (MOX), and closantel (CLOS). The efficacy percentages ranged from 0 to 92%, 0 to 75%, 0 to 91%, 69 to 97%, and 0 to 85% for ABZ, IVM, LEV, MXD and CLOS respectively in the Caatinga bioma, and 0 to 59% for ABZ and 9 to 59% for IVM in the Mata Atlântica biome. Most herds showed efficacy lower than 95% for anthelmintics, with the exception of one herd in which the efficacy for MOX was 97%. The results indicated the presence of GINs resistant to main anthelmintics classes in goat herds in these biomes.

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Section: Discussionunclassified

Resistência anti-helmíntica em rebanhos caprinos nos biomas Caatinga e Mata Atlântica

et al. 2015

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“…The anthelmintic resistance can reach enormous proportions when parasites develop mutations in their genome against different groups of anthelmintic drugs. Such phenomenon is known as "Multiple anthelmintic resistance" and it is a real threat to the inefficacy of commercially available anthelmintics (Taylor et al, 2009;Saeed et al, 2010). Such situation has motivated workers around the world to look for alternatives to control these parasites.…”

Section: Chemotherapy As the Unique Methods Of Controlmentioning

confidence: 99%

Plant Extracts: A Potential Tool for Controlling Animal Parasitic Nematodes

Gives¹,

Arellano²,

Hernández³

et al. 2012

The Biosphere

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“…As a result small ruminant production in the tropics and elsewhere is greatly reduced due to diseases caused by helminths [1] , and helminth infection is shown in up to 95 percent of small ruminants [1] . In Pakistan, prevalence of anthelmintic ineffectiveness, in sheep and goats, has been reported by several authors [8][9][10][11] . Recently, in Pakistan, one of the important factors of high prevalence of GINs infections in small ruminants might be due to the loss of anthelmintic activity [8,9,[12][13][14] .…”

Section: Introductionmentioning

confidence: 96%

Pakistan’ın Kuzey Punjab Eyaletindeki Koyun ve Keçilerde Haemonchus contortus ve Teladorsagia circumcincta’nın Anthelmentiklere Karşı Direncinin Belirlenmesi

Muhammad¹,

Ahmed²,

Iqbal³

et al. 2015

Kafkas Univ Vet Fak Derg

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The present study was conducted to investigate the efficacy of albendazole, levamisole and ivermectin against gastrointestinal nematodes of sheep and goats. One hundred and sixty small ruminants comprised four breeds, sheep (Salt range and Pak Karakul) and goats (Jattal and Beetal) were selected for this experiment. These animals were artificially infected with nematodes (Haemonchus contortus and Teladorsagia circumcincta). FECs were done to confirm the presence of adult stages of H. contortus and T. circumcincta. The selected sheep and goat were divided into four groups. First group was treated with albendazole, second with levamisole, third with ivermectin and fourth kept as untreated to serve as control. Faecal samples were collected on day first prior to administration of treatment followed by day 14 post treatment. The efficacy of each anthelmintic was measured using the faecal egg count reduction test and egg hatch test. The percentage reduction in FECs (95% CI) for albendazole, levamisole and ivermectin for salt range sheep were 88%, 89% and 99%, for Pak karakul sheep, 91%, 90% and 97%, for Jattal goat 91%, 91% and 98%, and for Beetal goat 91%, 92% and 99%. All results showed the presence of multiple anthelmintic resistances in selected sheep and goats flocks. All flocks were found resistance against the albendazol and three were resistance against levamisole. The arithmetic faecal egg count reduction with albendazole, levamisole and ivermectin recorded for H. contortus and T. circumcincta indicated the resistance against albendazole and levamisole and susceptibility of these worms against ivermectin. The results revealed that a significant difference (P<0.05) of FECRT were found on pre-treatment and post-treatment with different anthelmintic drug as compared to control group in all the flocks. The results of egg hatch test indicated that LC 50 were ranged from 0.138 µg/mL to 0.141 µg/mL for four breeds, which were more than 0.1ug/ml of albendazole. Result indicates that resistance was found in the eggs with albendazole. The egg hatch assay also confirmed the result of faecal egg count reduction test. gününde dışkı örnekleri toplandı. Herbir anthelmentiğin etkinliği dışkı yumurta sayımı azalma testi ve yumurta açılımı testi ile belirlendi. Albendazol, levamizol ve ivermektin için dışkı yumurta sayımında % azalma Salt range koyununda sırasıyla %88, %89 ve %99, Pak karakul koyununda %91, %90 ve %97, Jattal keçisinde %91, %91 ve %98, ve Beetal keçisinde %91, %92 ve %99 olarak tespit edildi. Çalışmanın sonuçları seçilen koyun ve keçi sürülerinde anthelmentik direncin mevcut olduğunu göstermiştir. Tüm sürüler albendazola karşı dirençli bulunurken üçü levamizole karşı dirençliydi. H. contortus ve T. circumcincta için albendazol, levamizol ve ivermektin ile tespit edilen aritmetik dışkı yumurta sayımı azalma albendazol ve levamizole karşı direnci gösterirken ivermektine karşı duyarlılığı ortaya koymuştur. Tüm sürülerde kontrol grubu ile karşılaştırıldığında uygulama öncesi ve sonrası arasında dışkı yumur...

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Multiple anthelmintic resistance and the possible contributory factors in Beetal goats in an irrigated area (Pakistan)

Cited by 20 publications

References 29 publications

Resistência anti-helmíntica em rebanhos caprinos nos biomas Caatinga e Mata Atlântica

Resistência anti-helmíntica em rebanhos caprinos nos biomas Caatinga e Mata Atlântica

Plant Extracts: A Potential Tool for Controlling Animal Parasitic Nematodes

Pakistan’ın Kuzey Punjab Eyaletindeki Koyun ve Keçilerde Haemonchus contortus ve Teladorsagia circumcincta’nın Anthelmentiklere Karşı Direncinin Belirlenmesi

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