Multiple and solitary skeletal muscle metastases on 18F-FDG PET/CT imaging

Nocuń, Anna; Chrapko, Beata

doi:10.1097/mnm.0000000000000368

Cited by 20 publications

(20 citation statements)

References 27 publications

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“…According to Nocuń et al . 2015 [8], three patterns exists. The first pattern is multiple skeletal muscle metastasis generally accompanied by other metastases in lymph nodes and organs.…”

Section: Discussionmentioning

confidence: 99%

Long-term complete response in a breast cancer patient with skeletal muscle metastases diagnosed using 18F-FDG-PET

Bello-Roufai

Soares

Kerrou

et al. 2017

Oxford Medical Case Reports

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Common sites for metastatic spreading from breast cancer are bones, lungs and liver, the skeletal muscle being an unusual site. Although rare, when skeletal muscle metastases occur they are associated with a poor prognosis. These metastases are clinically difficult to diagnose since they can be found without pain symptoms. Radiologically, magnetic resonance imaging has been considered better than computed tomography for imaging of the muscles and has been the first procedure to use in case of muscle metastasis suspicion. In the last years, positron emission tomography (PET) with 18Fluorine-2-fluoro-2-deoxy-d-glucose (18F-FDG) has emerged as the main imaging tool. We here report a case of a hormone receptor-positive/human epidermal growth factor receptor 2-negative patient who presented with a recurrent infiltrating ductal carcinoma and diffuse skeletal muscle metastases detected by 18F-FDG-PET. The treatment of the patient with exemestane and everolimus led to a durable complete response.

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“…According to Nocuń et al . 2015 [8], three patterns exists. The first pattern is multiple skeletal muscle metastasis generally accompanied by other metastases in lymph nodes and organs.…”

Section: Discussionmentioning

confidence: 99%

Long-term complete response in a breast cancer patient with skeletal muscle metastases diagnosed using 18F-FDG-PET

Bello-Roufai

Soares

Kerrou

et al. 2017

Oxford Medical Case Reports

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“…Despite these advantages, the use of 18F-FDG PET/CT for the detection of STM of lung cancer has not been widely researched. In previous studies, the prevalence of STM varied from 0.86-13% [13,28]. In our review, we found that approximately 1.87% of patients with lung cancer had STM.…”

Section: Survival Timementioning

confidence: 57%

“…18 F-FDG PET/CT can show metabolic changes before morphological abnormalities occur, and is used to screen for extra-pulmonary metastases in patients with lung cancer [10]. It is a whole-body imaging technique, with high tumor-to-background FDG uptake ratio, which allows detection of hidden STM [13,28]. Despite these advantages, the use of 18F-FDG PET/CT for the detection of STM of lung cancer has not been widely researched.…”

Section: Survival Timementioning

confidence: 99%

18F-FDG PET/CT is Valuable in Detecting Soft-tissue Metastasis of Lung Cancer

Zhang

et al. 2020

Preprint

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Background Soft-tissue metastasis (STM) is a relatively rare, but not exceptional, manifestation of lung cancer. Since the lesions of STM are usually asymptomatic, they are easy to miss during clinical evaluation. The aim of the study was to explore the incidence and characteristics of STM in lung cancer using fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography ( 18 F-FDG PET/CT), and evaluate its effect on tumor staging and treatment. Methods We analyzed 4543 patients with lung cancer who underwent 18 F-FDG PET/CT in our hospital between January 2013 and September 2018. 85 were diagnosed with STM and included in the study group. Imaging characteristics, clinical symptoms, and survival time (from confirmed STM to death) were recorded for all study subjects. Results A total of 219 lesions were identified by 18 F-FDG PET/CT: 215 were detected by PET (maximum standardized uptake value = 6.12); 139 were detected by CT. Muscle STM were primarily found in the hip, upper limb muscle; whereas subcutaneous STM were mainly distributed in the chest and abdomen, back. In 68 patients (80%), STM were found incidentally during routine 18 F-FDG PET/CT staging. The lesions were symptomatic in 17 cases (20%); in 10 patients (11.8%) STM was the first manifestation. Other site metastases were detected in 79 patients (92.9%). Isolated STM were found in 6 patients (7.1%), whose tumor staging and treatment were affected by PET/CT findings. At the end of the follow-up period, 69 patients were dead (median survival time= 5.0 months) and 5 were lost to follow-up. Conclusions STM may be a sign of advanced stage and poor prognosis in lung cancer. 18 F-FDG PET/CT is highly valuable in the detection of STM, and can impact tumor staging and management of lung malignancies.

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“…Different mechanisms for metastasis to skeletal muscles are proposed. These include lymphatics, haematogenous, muscle trauma and surgical implantation 2 11. In the case reported by Tunio, they found two sites of muscular metastasis in gluteus maximus and rectus abdominis muscles in a 28-year-old man with known colon adenocarcinoma.…”

Section: Discussionmentioning

confidence: 98%

“…Skeletal muscle metastasis is a very rare condition, accounting for less than 1% of metastasis, due to the improper environment of musculature for tumour growth 1 2. Despite its rare nature, it is reported in a large variety of primary malignancies including lung,3 lymphoma,4 renal cell carcinoma,5 gastrointestinal tract tumours,6 ovarian, thyroid, pancreatic and breast,7 with lung being the most common primary neoplasm 8.…”

Section: Introductionmentioning

confidence: 99%

Rectal adenocarcinoma presenting with thigh muscle metastasis as the only metastatic site

et al. 2019

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Rectal carcinoma with metastasis to skeletal muscle is a rare finding. According to literature review, 17 cases of skeletal muscle metastasis from colorectal carcinoma have been documented where only six cases were rectal carcinomas.We discuss a case of a middle-aged man with a known history of high-grade mucinous adenocarcinoma of the rectum, status post abdominoperineal resection followed by adjuvant radiotherapy and chemotherapy. During the planned chemotherapy course, a right proximal thigh subcutaneous mass was incidentally found which on subsequent biopsy proved to be metastatic from rectal primary site. On subsequent 18F-FDG (Fluorodeoxyglucose) positron emission tomography (PET)/CT scan after completion of chemotherapy for the purpose of treatment response evaluation, only FDG-avid lesion was residual right proximal thigh metastatic mass without involvement of other common sites, such as liver and lung. In this case, the 18F-FDG-PET/CT scan was able to exclude additional metastatic sites and also evaluate the patient’s treatment response.

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Multiple and solitary skeletal muscle metastases on 18F-FDG PET/CT imaging

Cited by 20 publications

References 27 publications

Long-term complete response in a breast cancer patient with skeletal muscle metastases diagnosed using 18F-FDG-PET

Long-term complete response in a breast cancer patient with skeletal muscle metastases diagnosed using 18F-FDG-PET

18F-FDG PET/CT is Valuable in Detecting Soft-tissue Metastasis of Lung Cancer

Rectal adenocarcinoma presenting with thigh muscle metastasis as the only metastatic site

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