Multiphoton Fluorescence and Second-Harmonic-Generation Microscopy for Imaging Structural Alterations in Corneal Scar Tissue in Penetrating Full-Thickness Wound

Quantitative Discrimination of Healthy and Diseased Corneas With Second Harmonic Generation Microscopy

“…A few representative examples of corneal pathologies have been presented along this work (keratoconus, edema, and bullous keratopathy). However, the procedure can also be applied to corneal tissues suffering from other diseases, such as infectious keratitis,14–17 fibrosis,21,22 scars,14,36 and diabetes mellitus 37…”

Quantitative Discrimination of Healthy and Diseased Corneas With Second Harmonic Generation Microscopy

“…A few representative examples of corneal pathologies have been presented along this work (keratoconus, edema, and bullous keratopathy). However, the procedure can also be applied to corneal tissues suffering from other diseases, such as infectious keratitis,14–17 fibrosis,21,22 scars,14,36 and diabetes mellitus 37…”

High-resolution, label-free two-photon imaging of diseased human corneas

“…The feasibility of TPI to monitor the scar tissue formation during wound healing has been demonstrated. 33 In addition to SHG, the collagen and keratocytes in the corneal stroma generate AF signals. In this study, differences of the stroma mean AF lifetimes were observed between NP and pathological corneas as well as between different pathologies [ Fig.…”

Multiphoton microscopy for monitoring the occurrence, metastasis and therapy of breast cancer

“…With the development of technology, people look forward to the practical application of MPM in disease diagnosis. Currently, the application of MPM in medical diagnosis mainly focuses on gastrointestinal tumors, 33–45 skin diseases, 46–51 and corneal diseases 52–61 …”

“…Currently, the application of MPM in medical diagnosis mainly focuses on gastrointestinal tumors, [33][34][35][36][37][38][39][40][41][42][43][44][45] skin diseases, [46][47][48][49][50][51] and corneal diseases. [52][53][54][55][56][57][58][59][60][61]…”

Quantitative Discrimination of Healthy and Diseased Corneas With Second Harmonic Generation Microscopy

“…A few representative examples of corneal pathologies have been presented along this work (keratoconus, edema, and bullous keratopathy). However, the procedure can also be applied to corneal tissues suffering from other diseases, such as infectious keratitis,14–17 fibrosis,21,22 scars,14,36 and diabetes mellitus 37…”

High-resolution, label-free two-photon imaging of diseased human corneas

“…The feasibility of TPI to monitor the scar tissue formation during wound healing has been demonstrated. 33 In addition to SHG, the collagen and keratocytes in the corneal stroma generate AF signals. In this study, differences of the stroma mean AF lifetimes were observed between NP and pathological corneas as well as between different pathologies [ Fig.…”

Multiphoton microscopy for monitoring the occurrence, metastasis and therapy of breast cancer

“…With the development of technology, people look forward to the practical application of MPM in disease diagnosis. Currently, the application of MPM in medical diagnosis mainly focuses on gastrointestinal tumors, 33–45 skin diseases, 46–51 and corneal diseases 52–61 …”

“…Currently, the application of MPM in medical diagnosis mainly focuses on gastrointestinal tumors, [33][34][35][36][37][38][39][40][41][42][43][44][45] skin diseases, [46][47][48][49][50][51] and corneal diseases. [52][53][54][55][56][57][58][59][60][61]…”

Quantitative Discrimination of Healthy and Diseased Corneas With Second Harmonic Generation Microscopy

“…A few representative examples of corneal pathologies have been presented along this work (keratoconus, edema, and bullous keratopathy). However, the procedure can also be applied to corneal tissues suffering from other diseases, such as infectious keratitis,14–17 fibrosis,21,22 scars,14,36 and diabetes mellitus 37…”

High-resolution, label-free two-photon imaging of diseased human corneas

“…The feasibility of TPI to monitor the scar tissue formation during wound healing has been demonstrated. 33 In addition to SHG, the collagen and keratocytes in the corneal stroma generate AF signals. In this study, differences of the stroma mean AF lifetimes were observed between NP and pathological corneas as well as between different pathologies [ Fig.…”

Multiphoton microscopy for monitoring the occurrence, metastasis and therapy of breast cancer

“…With the development of technology, people look forward to the practical application of MPM in disease diagnosis. Currently, the application of MPM in medical diagnosis mainly focuses on gastrointestinal tumors, 33–45 skin diseases, 46–51 and corneal diseases 52–61 …”

“…Currently, the application of MPM in medical diagnosis mainly focuses on gastrointestinal tumors, [33][34][35][36][37][38][39][40][41][42][43][44][45] skin diseases, [46][47][48][49][50][51] and corneal diseases. [52][53][54][55][56][57][58][59][60][61]…”