Multiparametric ultrasound findings in acute kidney failure due to rare renal cortical necrosis

Spiesecke, Paul; Muench, Frédéric; Fischer, Thomas; Hamm, Bernd; Lerchbaumer, Markus Herbert

doi:10.1038/s41598-021-81690-x

Cited by 10 publications

(13 citation statements)

References 28 publications

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“…In the differential diagnosis between renal cortical necrosis (RCN) and renal vein thrombosis (RVT), the Doppler US plays an important role. Spiesecke P. et al [40] have…”

Section: Renal Vein Thrombosismentioning

confidence: 96%

“…In the differential diagnosis between renal cortical necrosis (RCN) and renal vein thrombosis (RVT), the Doppler US plays an important role. Spiesecke P. et al [40] have shown that the resistive index (RI) is a very important distinguishing feature to separate RCN (RI not measurable due to hypoperfusion) and RVT (RI > 1). However, in unclear cases, the use of a contrast agent, which will demonstrate renal medulla enhancement only in patients with NCR and the absence of enhancement in patients with RVT, may be useful.…”

Section: Renal Vein Thrombosismentioning

confidence: 99%

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Role of Contrast-Enhanced Ultrasound (CEUS) in Native Kidney Pathology: Limits and Fields of Action

Granata

Campo²,

Lentini

et al. 2021

Diagnostics

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Gray scale ultrasound has an important diagnostic role in native kidney disease. Low cost, absence of ionizing radiation and nephrotoxicity, short performance time, and repeatability even at the bedside, are the major advantages of this technique. The introduction of contrast enhancement ultrasound (CEUS) in daily clinical practice has significantly reduced the use of contrast enhancement computed tomography (CECT) and contrast enhancement magnetic resonance (CEMR), especially in patients with renal disease. Although there are many situations in which CECT and CEMRI are primarily indicated, their use may be limited by the administration of the contrast medium, which may involve a risk of renal function impairment, especially in the elderly, and in patients with acute kidney injury (AKI) and moderate to severe chronic kidney disease (CKD). In these cases, CEUS can be a valid diagnostic choice. To date, numerous publications have highlighted the role of CEUS in the study of parenchymal micro-vascularization and renal pathology by full integration with second level imaging methods (CECT and CEMRI) both in patients with normal renal function and with diseased kidneys. The aim of this review is to offer an updated overview of the limitations and potential applications of CEUS in native kidney disease.

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“…In the differential diagnosis between renal cortical necrosis (RCN) and renal vein thrombosis (RVT), the Doppler US plays an important role. Spiesecke P. et al [40] have…”

Section: Renal Vein Thrombosismentioning

confidence: 96%

Section: Renal Vein Thrombosismentioning

confidence: 99%

Role of Contrast-Enhanced Ultrasound (CEUS) in Native Kidney Pathology: Limits and Fields of Action

Granata

Campo²,

Lentini

et al. 2021

Diagnostics

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show abstract

“…In addition to its good safety profile and simplicity, CEUS is also patient-friendly, has no ionizing radiation, and can enable multiplanar imaging in real time ( 15 , 16 ). Particularly, in patients with acute kidney disease, CEUS is a suitable imaging method since, unlike contrast-enhanced computed tomography (CE-CT) contrast agents containing iodine, ultrasound contrast agents do not cause nephrotoxicity ( 17 ). Scholars are currently using CEUS to diagnose IVL, obtaining more information than conventional ultrasound, particularly the tiny blood inside the lesion, which is critical for IVL differential diagnosis ( 18 ).…”

Section: Introductionmentioning

confidence: 99%

Diagnostic value of contrast-enhanced ultrasound in intravenous leiomyomatosis: a single-center experiences

Wang

et al. 2022

Front. Oncol.

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ObjectiveIntravenous leiomyomatosis (IVL) is a rare disease, and few studies have focused on the diagnostic value of contrast-enhanced ultrasound (CEUS) in this condition. This study aimed to investigate the diagnostic value of CEUS in IVL and summarize the specific CEUS characteristics of IVL.Materials and MethodFrom December 2016 to March 2021, 93 patients admitted to our hospital with inferior vena cava (IVC) occupying lesions were prospectively enrolled and underwent detailed ultrasound multi-modality examinations, including conventional and contrast-enhanced ultrasound scans. The diagnostic value of CEUS and conventional ultrasound (CU) in IVL was compared, and the specific IVL signs were summarized.ResultsAmong the 93 patients with inferior vena cava mass, 67 were IVL while 26 were non-IVL. The inter-observer agreement of the two senior doctors was good, with Kappa coefficient = 0.71 (95% CI: 0.572–0.885). The area under the ROC curve of CU for IVL diagnosis was 0.652 (95% CI: 0.528–0.776), and its sensitivity, specificity, accuracy, positive predictive value, negative predictive value, missed diagnosis rate, and misdiagnosis rate were 61.1%, 69.2%, 63.4%, 83.7%, 40.9%, 38.8%, and 30.8%, respectively. The area under curve (AUC) for IVL diagnosis by CEUS was 0.807 (95% CI: 0.701–0.911), and the sensitivity, specificity, accuracy, positive predictive value, negative predictive value, missed diagnosis rate, and misdiagnosis rate were 82.0%, 84.6%, 82.8%, 93.2%, 64.7%, 15.4%, and 17.9%, respectively. In CEUS mode, “sieve hole sign” and “multi-track sign” were detected in 57 lesions, and the detected rate was higher than that of CU (https://loop.frontiersin.org/people/1014187 < 0.01).ConclusionCEUS can better show the fine blood flow inside the IVL, which is important for IVL differential diagnosis. Moreover, CEUS can obtain more information about IVL diagnosis than CU, compensating for the shortcomings of CU in detecting more blood flow within the lesion. Thus, this technique has great significance for IVL diagnosis.

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“…The most commonly applied method for renal imaging is ultrasonography. It is also a non-invasive, non-ionizing technique, which provides the ability to dynamically image morphological abnormalities with high resolution, to measure blood flow with the Doppler method, and to apply a safe contrast agent to visualize perfusion without harming the kidney [86][87][88][89]. In contrast to MRI, it is widely available and cost-efficient [90].…”

Section: Discussionmentioning

confidence: 99%

Multiparametric Functional MRI of the Kidney: Current State and Future Trends with Deep Learning Approaches

Zhang¹,

Schwartz

Küstner³

et al. 2022

Rofo

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Background Until today, assessment of renal function has remained a challenge for modern medicine. In many cases, kidney diseases accompanied by a decrease in renal function remain undetected and unsolved, since neither laboratory tests nor imaging diagnostics provide adequate information on kidney status. In recent years, developments in the field of functional magnetic resonance imaging with application to abdominal organs have opened new possibilities combining anatomic imaging with multiparametric functional information. The multiparametric approach enables the measurement of perfusion, diffusion, oxygenation, and tissue characterization in one examination, thus providing more comprehensive insight into pathophysiological processes of diseases as well as effects of therapeutic interventions. However, application of multiparametric fMRI in the kidneys is still restricted mainly to research areas and transfer to the clinical routine is still outstanding. One of the major challenges is the lack of a standardized protocol for acquisition and postprocessing including efficient strategies for data analysis. This article provides an overview of the most common fMRI techniques with application to the kidney together with new approaches regarding data analysis with deep learning. Methods This article implies a selective literature review using the literature database PubMed in May 2021 supplemented by our own experiences in this field. Results and Conclusion Functional multiparametric MRI is a promising technique for assessing renal function in a more comprehensive approach by combining multiple parameters such as perfusion, diffusion, and BOLD imaging. New approaches with the application of deep learning techniques could substantially contribute to overcoming the challenge of handling the quantity of data and developing more efficient data postprocessing and analysis protocols. Thus, it can be hoped that multiparametric fMRI protocols can be sufficiently optimized to be used for routine renal examination and to assist clinicians in the diagnostics, monitoring, and treatment of kidney diseases in the future. Key Points: Citation Format

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Multiparametric ultrasound findings in acute kidney failure due to rare renal cortical necrosis

Cited by 10 publications

References 28 publications

Role of Contrast-Enhanced Ultrasound (CEUS) in Native Kidney Pathology: Limits and Fields of Action

Role of Contrast-Enhanced Ultrasound (CEUS) in Native Kidney Pathology: Limits and Fields of Action

Diagnostic value of contrast-enhanced ultrasound in intravenous leiomyomatosis: a single-center experiences

Multiparametric Functional MRI of the Kidney: Current State and Future Trends with Deep Learning Approaches

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