Multiorgan Fatal Chronic Complications Following Radiation Treatment for Cancer of the Cervix—Results of Fibroblast Assay

Severe normal tissue complication correlates with increased in vitro fibroblast radiosensitivity in radical prostate radiotherapy: A case report

“…An earlier study at ORCC also showed that fraction number increased the ability to detect differences in radiosensitivity among human fibroblasts [5]. Our results agree with previous studies showing that severe clinical radiosensitivity is reflected by a significant increase in fibroblast radiosensitivity and suggest that there may be a genetic basis for such sensitivity even though the patients did not demonstrate any detectable symptoms [10,17,18], unlike AT patients [19,20]. A recent study at ORCC demon- strated that patients suffering radiation necroses following radiosurgery for arteriovenous malformations also have hypersensitive fibroblasts when tested in vitro [21].…”

“…In fact, we reported previously on a case study involving radiotherapy (teletherapy with a brachytherapy boost) of cancer of the cervix. In this study, the hypersensitivity of the patient was correlated to the radiosensitivity of the fibroblasts in vitro [17]. We observed an abnormally severe normal tissue late reaction in one of our patients undergoing radical radiotherapy for prostate carcinoma.…”

Comparison of high dose rate, low dose rate, and high dose rate fractionated radiation for optimizing differences in radiosensitivities in vitro

“…The S11358 cell line was grown from a biopsy from a 33-year-old female patient with cervical cancer who had severe chronic normal tissue injury following conventional irradiation [18]. The cells, already in culture, were obtained from the Atomic Energy of Canada Limited, Chalk River.…”