This study assessed the association of chronic conditions and multimorbidity with perceived stress among community-dwelling adults in 44 low-and middle-income countries. Data were analyzed from the World Health Survey (2002)(2003)(2004) (18.29, 22.05) respectively. The associations with perceived stress were significantly stronger among the poorest for arthritis, asthma, diabetes, edentulism, and â„4 chronic conditions. Our data suggest that a range of chronic conditions and multimorbidity are associated with greatly increased perceived stress among people in low-and middle-income countries, and that the poorest may be a particularly vulnerable group.