Multimorbidity and quality of life - Systematic literature review and meta-analysis

Makovski, Tatjana T.; Schmitz, Susanne; Akker, Marjan van den; Zeegers, Maurice P.; Stranges, Saverio

doi:10.1016/j.respe.2018.05.242

Cited by 54 publications

(64 citation statements)

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“…The ndings of the present study are also consistent with those of recent population-based systematic review which investigated on the association between QoL and multimorbidity [78]. In their recent study, Makovski et al (2019) systematically reviewed the evidence on the relationship between QoL and multimorbidity.…”

Section: Discussionsupporting

confidence: 91%

“…In their recent study, Makovski et al (2019) systematically reviewed the evidence on the relationship between QoL and multimorbidity. They observed a stronger relationship between the PCS of QoL and multimorbidity (overall decline in QoL per additional disease = -4.37%, 95%CI -7.13% to -1.61% for WHOQoL-BREF physical domain and -1.57%, 95%CI -2.70% to -0.44% for WHOQoL-BREF mental domain) [78]. These ndings also align with the results of the present study, where the meta-analysis indicated a stronger effect size for PCS compared to MCS using the SF-36 tool (pooled OR/RR = 0.950; 95% CI: 0.935 to 0.965 for PCS; and pooled OR/RR = 0.980; 95%CI: 0.969 to 0.992 for MCS).…”

Section: Discussionmentioning

confidence: 97%

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Quality of Life and mortality in the general population: a systematic review and meta-analysis

Phyo

Freak‐Poli

Craig

et al. 2020

Preprint

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Background: Quality of life (QoL) is multi-dimensional concept of an individual’ general well-being status in relation to their value, environment, cultural and social context in which they live. This study aimed to quantitatively synthesise available evidence on the association between QoL and mortality in the general population.Methods: An electronic search was conducted using three bibliographic databases, MEDLINE, EMBASE and PsycINFO. Inclusion criteria were studies that assessed QoL using standardized tools and examined mortality risk in a non-patient population. Qualitative data synthesis and meta-analyses using a random-effects model were performed.Results: Of 4,184 articles identified, 47 were eligible for inclusion, involving approximately 1,200,000 participants. Studies were highly heterogeneous in terms of QoL measures, population characteristics and data analysis. In total, 43 studies (91.5%) reported that better QoL was associated with lower mortality risk. The results of four meta-analyses indicated that higher health-related QoL (HRQoL) is associated with lower mortality risk, which was consistent for overall HRQoL (HR 0.633, 95% CI: 0.514 to 0.780), physical function (HR 0.987, 95% CI: 0.982 to 0.992), physical component score (OR 0.950, 95% CI: 0.935 to 0.965), and mental component score (OR 0.980, 95% CI: 0.969 to 0.992).Conclusion: These findings provide evidence that better QoL/HRQoL was associated with lower mortality risk. The utility of these measures in predicting mortality risk indicates that they should be considered further as potential screening tools in general clinical practice, beyond the traditional objective measures such as body mass index and the results of laboratory tests.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 97%

Quality of Life and mortality in the general population: a systematic review and meta-analysis

Phyo

Freak‐Poli

Craig

et al. 2020

Preprint

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“…Individuals can acquire ADLs from diabetes without having other chronic conditions (eg, one can have diabetic neuropathy that manifests as an ADL without having a direct heart disease diagnosis) or they can have other chronic conditions without having ADLs. Research documents an inverse relationship between multimorbidity and QoL, 30 31 and so we consider having other chronic conditions or ADLs as reducing QoL. This QoL measure, %XLE, is calculated by the number of years spent with only diabetes (XLE) divided by total life expectancy (TLE) in the diabetic status–based LTs.…”

Section: Methodsmentioning

confidence: 99%

Regional differences in the impact of diabetes on population health in the USA

Zang

Lynch²,

West

2020

J Epidemiol Community Health

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BackgroundTo evaluate regional disparities in the influence of diabetes on population health, we examine life expectancies at age 50 between population with diabetes and healthy population and life quality among the population with diabetes among native-born Americans by birth region and current residence.MethodsUsing data on a cohort of 17 686 native-born individuals from the Health and Retirement Survey (1998–2014), we applied a Bayesian multistate life table method to estimate life expectancies at age 50 between population with diabetes and healthy population by each birth/current region combination. We further estimate the proportion of life remaining without either chronic conditions or disabilities as a quality of life measure and the probabilities that one region is worse than the other in terms of different health outcomes.ResultsAt age 50, persons with diabetes (PWD) were expected to live on average 5.8–10.8 years less than their healthy equivalents across regions. Diabetes had the greatest influence on life expectancy (LE) for older adults who lived in the South at the time of interviews. PWD born in the South were more likely to have developed chronic conditions or disabilities and spent greater proportions of life with these two issues compared to other regions.ConclusionDiabetes is a significant threat to LE and healthy LE in the USA, particularly for people born or living in the South.

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“…Further, complex multimorbidity defined as three or more chronic conditions affecting three or more different body systems is suggested to better identify patients needing care from different specialists than multimorbidity [8]. Multimorbidity has in systematic reviews been found to be associated with functional decline [9], poor quality of life [10] and increased mortality [11] amongst older persons. There has been found gender and socioeconomic differences where women and lower educated groups have higher prevalence of multimorbidity than men and higher educated groups [12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Associations between complex multimorbidity, activities of daily living and mortality among older Norwegians. A prospective cohort study: the HUNT Study, Norway

et al. 2020

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Background: With increasing age, having multiple chronic conditions is the norm. It is of importance to study how coexistence of diseases affects functioning and mortality among older persons. Complex multimorbidity may be defined as three or more conditions affecting at least three different organ systems. The aim of this study was to investigate how complex multimorbidity affects activities of daily living and mortality amongst older Norwegians. Methods: Participants were 60-69-year-olds at baseline in the Nord-Trøndelag Health Study 1995-1997 (HUNT2) n = 9058. Multinomial logistic regression models were used to investigate the association between complex multimorbidity in HUNT2, basic and instrumental activities of daily living in HUNT3 (2006-2008) and mortality during follow-up (n = 5819/5836). Risk ratios (RR) and risk differences (RD) in percentage points (pp) with 95% confidence intervals (CI) were reported. Results: 47.8% of 60-69-year-olds met the criteria of complex multimorbidity at baseline (HUNT2). Having complex multimorbidity was strongly associated with the need for assistance in IADL in HUNT3 11 years later (RR = 1.80 (1.58-2.04) and RD = 8.7 (6.8-10.5) pp) and moderately associated with mortality during the follow-up time (RR = 1.22 (1.12-1.33) and RD = 5.1 (2.9-7.3) pp). Complex multimorbidity was to a lesser extent associated with basic activities of daily living 11 years later (RR = 1.24 (0.85-1.83) and RD = 0.4 (− 0.3-1.1) pp). Conclusions: This is the first study to show an association between complex multimorbidity and activities of daily living. Complex multimorbidity should receive more attention in order to prevent future disability amongst older persons.

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Multimorbidity and quality of life - Systematic literature review and meta-analysis

Cited by 54 publications

References 0 publications

Quality of Life and mortality in the general population: a systematic review and meta-analysis

Quality of Life and mortality in the general population: a systematic review and meta-analysis

Regional differences in the impact of diabetes on population health in the USA

Associations between complex multimorbidity, activities of daily living and mortality among older Norwegians. A prospective cohort study: the HUNT Study, Norway

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