Multimodal Treatment of Primary Extraskeletal Ewing's Sarcoma of the Chest Wall: Report of 2 Cases

Abstract

Extraskeletal Ewing's sarcoma (EES) is a type of Ewing's sarcoma that arises in soft tissue and is now regarded as a member of a family of small round cell neoplasms of bone and soft tissue, including primitive neuroectodermal tumors (PNETs). EES occurs predominantly in adolescents and young adults between the ages of 10 and 30 years. The disease follows an aggressive course with a high recurrence rate. The presence of a distant metastasis is also common. EES arises in the soft tissue of either the trunk or extremities. We recently experienced two cases of EES that occurred in the chest wall. The two patients underwent wide resection and combined radiochemotherapy. There was no evidence of disease 30 and 22 months, respectively, after surgery. Although extremely rare, EES should be considered in the differential diagnosis of chest wall tumors. We report two cases of EES with a brief review of the literature.

Scapular bone destruction: do not forget to think of tuberculosis in endemic areas

“…Osteosarcomas and round cell tumours (Ewing sarcoma) can involve scapula and usually present as painful masses. Both of these have a bimodal age presentation and can affect young as well as elderly population 8 11…”

Primary Ewing’s Sarcoma of Penis – A Rare Case Report

“…Expression of the MIC2 gene is path-gnomonic for Ewing's sarcoma, but it may also occur in some cases of Tlymphoblastic lymphoma, poorly differentiated synovial sarcoma, small cell osteosarcoma and rhabdomyosarcoma. Ewing's sarcoma can be definitively diagnosed by detection of the EWS gene and rearrangement of ETS-related cancer genes [6].…”

“…Multidrug chemotherapy is more effective than single-drug chemotherapy for the treatment of Ewing's sarcoma. It has been demonstrated that preoperative chemotherapy with the use of a combination of vincristine, doxorubicine, cyclophosphamide and etoposide allows for conservative surgical resection in selected cases with subsequent improvement of the postoperative condition [6].…”

“…Major prognostic factors include the absence or presence of a metastasis, tumor size, the extent of necrosis, the initial response to chemotherapy and the presence of EWS/FL 11 fusion transcripts [6].…”

Extraosseous Ewing’s Tumor of Lateral Abdominal Wall

“…1 About 82 cases of cutaneous or subcutaneous ES reported in the literature. 2 We are reporting this case because of the rarity of this tumor.…”