Multimodal treatment of locally advanced transitional cell bladder carcinoma in elderly patients

Veronesi, Andrea; Re, Giovanni Lo; Carbone, Antonino; Trovò, M.; Bò, V. Dal; Talamini, Renato; Santarossa, Sandra; Francini, M.; Monfardini, S.

doi:10.1016/0959-8049(94)90114-7

Cited by 3 publications

(2 citation statements)

References 9 publications

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“…Additionally, Sengelov and coworkers [ 31 ] confirmed that curative intended radiotherapy is feasible in elderly patients, with 29% surviving for 2 years. The overall actuarial median survival under 2DRT techniques in these reports ranged from 9 to 21.5 months [ 30 , 32 , 33 ]. In our institute, the median survival is 21 months.…”

Section: Discussionmentioning

confidence: 99%

Intensity modulated radiotherapy for elderly bladder cancer patients

et al. 2011

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BackgroundTo review our experience and evaluate treatment planning using intensity-modulated radiotherapy (IMRT) and helical tomotherapy (HT) for the treatment of elderly patients with bladder cancer.MethodsFrom November 2006 through November 2009, we enrolled 19 elderly patients with histologically confirmed bladder cancer, 9 in the IMRT and 10 in the HT group. The patients received 64.8 Gy to the bladder with or without concurrent chemotherapy. Conventional 4-field "box" pelvic radiation therapy (2DRT) plans were generated for comparison.ResultsThe median patient age was 80 years old (range, 65-90 years old). The median survival was 21 months (5 to 26 months). The actuarial 2-year overall survival (OS) for the IMRT vs. the HT group was 26.3% vs .37.5%, respectively; the corresponding values for disease-free survival were 58.3% vs. 83.3%, respectively; for locoregional progression-free survival (LRPFS), the values were 87.5% vs. 83.3%, respectively; and for metastases-free survival, the values were 66.7% vs. 60.0%, respectively. The 2-year OS rates for T1, 2 vs. T3, 4 were 66.7% vs. 35.4%, respectively (p = 0.046). The 2-year OS rate was poor for those whose RT completion time greater than 8 weeks when compared with the RT completed within 8 wks (37.9% vs. 0%, p = 0.004).ConclusionIMRT and HT provide good LRPFS with tolerable toxicity for elderly patients with invasive bladder cancer. IMRT and HT dosimetry and organ sparing capability were superior to that of 2DRT, and HT provides better sparing ability than IMRT. The T category and the RT completion time influence OS rate.

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Section: Discussionmentioning

confidence: 99%

Intensity modulated radiotherapy for elderly bladder cancer patients

et al. 2011

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“…One patient was receiving treatment for recurrent breast carci-mined according to ICRU Report 50. 17 Treatment schedules are summarized in Table 2 This patient also developed Grade 2 skin, lower gastro-FUMIR: 5-fluorouracil, mitomycin C, and radiation; Gy: grays.…”

Section: Methodsmentioning

confidence: 99%