Multimodal Molecular Imaging of the Tumour Microenvironment

Foray, Claudia; Barca, Cristina; Backhaus, Philipp; Schelhaas, Sonja; Winkeler, Alexandra; Viel, Thomas; Schäfers, Michael; Grauer, Oliver; Zinnhardt, Bastian

doi:10.1007/978-3-030-35727-6_5

Cited by 22 publications

(10 citation statements)

References 121 publications

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“…The occurrence and development of the tumor is not only related to its own malignant proliferation but also closely related to TME [ 31 ]. TME is a highly dynamic and heterogeneous composition of immune cells, fibroblasts, precursor cells, endothelial cells, signaling molecules, and extracellular matrix components [ 32 ]. COX-2 (also known as PTGS2), released by cancer-associated fibroblasts (CAFs) [ 33 ] and macrophage type 2 cells [ 34 ], is one of the key markers predicting worse cancer prognosis and stimulates cancer via multiple ways in the TME [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

An Investigation of the Antigastric Cancer Effect in Tumor Microenvironment of Radix Rhei Et Rhizome: A Network Pharmacology Study

Wang

Zhu

Yang

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Background. Tumor microenvironment (TME) takes a vital effect on the occurrence and development of cancer. Radix Rhei Et Rhizome (RRER, Da-Huang in pinyin), a classical Chinese herb, has been widely used in gastric cancer (GC) for many years in China. However, inadequate systematic studies have focused on the anti-GC effect of RRER in TME. This study intended to uncover the mechanism of it by network pharmacology. Methods. We collected compounds and targets of RRER from traditional Chinese medicine system pharmacology database and analysis platform (TCMSP) and SwissTargetPrediction. GC targets were obtained from GeneCards. Protein-protein interaction (PPI) network and RRER-GC-target network were built by STRING and Cytoscape 3.2.1. Furthermore, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were performed using Database for Annotation, Visualization, and Integrated Discovery (DAVID). Results. We obtained 92 compounds of RRER. A total of 10 key compounds and 20 key targets were selected by “RRER-GC-target network” topological analysis. GO analysis showed that the biological process mainly involved in response to the tumor necrosis factor, positive regulation of fibroblast proliferation, and DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest. Molecular functions included cyclin-dependent protein serine/threonine kinase activity, RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding, and transmembrane receptor protein tyrosine kinase activity. Cellular components mainly were centrosome, cell surface, and membrane. KEGG pathway enrichment results mainly involved in the p53 signaling pathway, estrogen signaling pathway, and regulation of lipolysis in adipocytes. Conclusion. This study explored the anti-GC mechanism of RRER from the perspective of TME based on network pharmacology, which contributed to the development and application of RRER.

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Section: Discussionmentioning

confidence: 99%

An Investigation of the Antigastric Cancer Effect in Tumor Microenvironment of Radix Rhei Et Rhizome: A Network Pharmacology Study

Wang

Zhu

Yang

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…Recent developments in advanced MR and PET scanning have improved CNS imaging, up to the point that now we can collect specific information within brain TME compartments [ 105 , 106 , 107 ]. Nevertheless, a careful histo-morphological evaluation of tumour tissue by pathologists is still of fundamental importance, and features such as Scherer’s secondary structures are still a valuable clue into the diagnosis of diffuse, possibly high-grade gliomas.…”

Section: Discussionmentioning

confidence: 99%

Satellitosis, a Crosstalk between Neurons, Vascular Structures and Neoplastic Cells in Brain Tumours; Early Manifestation of Invasive Behaviour

Civita

Ortenzi

Naccarato

et al. 2020

Cancers

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The secondary structures of Scherer commonly known as perineuronal and perivascular satellitosis have been identified as a histopathological hallmark of diffuse, invasive, high-grade gliomas. They are recognised as perineuronal satellitosis when clusters of neoplastic glial cells surround neurons cell bodies and perivascular satellitosis when such tumour cells surround blood vessels infiltrating Virchow–Robin spaces. In this review, we provide an overview of emerging knowledge regarding how interactions between neurons and glioma cells can modulate tumour evolution and how neurons play a key role in glioma growth and progression, as well as the role of perivascular satellitosis into mechanisms of glioma cells spread. At the same time, we review the current knowledge about the role of perineuronal satellitosis and perivascular satellitosis within the tumour microenvironment (TME), in order to highlight critical knowledge gaps in research space.

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“…Recent developments in advanced MR and PET scanning have improved CNS imaging, up to the point that now we can collect specific information within brain TME compartments [110][111][112]. Nevertheless, a careful histo-morphological evaluation of tumour tissue by pathologists is still of GB cells interact with BBB:…”

Section: Discussionmentioning

confidence: 99%

Satellitosis, a Crosstalk Between Neurons, Vascular Structures and Neoplastic Cells in Brain Tumours; Early Manifestation of Invasive Behaviour

Civita¹,

Ortenzi²,

Naccarato³

et al. 2020

Preprint

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The secondary structures of Scherer commonly known as perineuronal and perivascular satellitosis have been identified as a histopathological hallmark of diffuse, invasive, high-grade gliomas. They are recognized as perineuronal satellitosis when clusters of neoplastic glial cells surround neurons cell bodies and perivascular satellitosis when such tumour cells surround blood vessels infiltrating Virchow-Robin spaces. In this review, we provide an overview of emerging knowledge regarding how interactions between neurons and glioma cells can modulate tumour evolution and how neurons play a key role in glioma growth and progression, as well as the role of perivascular satellitosis into mechanisms of glioma cells spread. At the same time, we review the current knowledge about the role of perineuronal satellitosis and perivascular satellitosis within the tumour microenvironment (TME), in order to highlight critical knowledge gaps in research space.

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Multimodal Molecular Imaging of the Tumour Microenvironment

Cited by 22 publications

References 121 publications

An Investigation of the Antigastric Cancer Effect in Tumor Microenvironment of Radix Rhei Et Rhizome: A Network Pharmacology Study

An Investigation of the Antigastric Cancer Effect in Tumor Microenvironment of Radix Rhei Et Rhizome: A Network Pharmacology Study

Satellitosis, a Crosstalk between Neurons, Vascular Structures and Neoplastic Cells in Brain Tumours; Early Manifestation of Invasive Behaviour

Satellitosis, a Crosstalk Between Neurons, Vascular Structures and Neoplastic Cells in Brain Tumours; Early Manifestation of Invasive Behaviour

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