Multilocational hepatocyte transplantation for treatment of congenital ascorbic acid deficiency rats

Nakazawa, Fumiaki; Onodera, Kenji; Katô, Kazuya; Sawa, Masayuki; Kino, Masuhisa; Imai, Masato; Kasai, S.; Mito, Michio; Matsushita, Takumi; Funatsu, Kazumori

doi:10.1016/0963-6897(96)00034-6

Cited by 6 publications

(1 citation statement)

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“…Multi-locational allogenic hepatocyte transplant for the treatment of ascorbic acid deficiency in rats was shown to be possible (Nakazawa et al, 1996). Cells were transplanted in the portal vein, spleen omentum, and mesentery.…”

Section: Primary Hepatocyte Transplant Research: From Tissues To Cellmentioning

confidence: 99%

The History and Use of Human Hepatocytes for the Treatment of Liver Diseases: The First 100 Patients

et al. 2014

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Orthotopic liver transplantation remains the only curative treatment for many end-stage liver diseases, yet the number of patients receiving liver transplants remains limited by the number of organs available for transplant. There is a need for alternative therapies for liver diseases. The transplantation of isolated hepatocytes (liver cells) has been used as an experimental therapy for liver disease in a limited number of cases. Recently, the 100 th case of hepatocyte transplantation was reported. This review discusses the history of the hepatocyte transplant field, the major discoveries that supported and enabled the first hepatocyte transplants, and reviews the cases and outcomes of the first 100 clinical transplants. Some of the problems that limit the application or efficacy of hepatocyte transplantation are discussed, as are possible solutions to these problems. In conclusion, hepatocyte transplants have proven effective particularly in cases of metabolic liver disease where reversal or amelioration of the characteristic symptoms of the disease is easily quantified. However, no patients have been completely corrected of a metabolic liver disease for a significant amount of time by hepatocyte transplantation alone. It is likely that future developments in new sources of cells for transplantation will be required before this cellular therapy can be fully implemented and available for large numbers of patients.

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Section: Primary Hepatocyte Transplant Research: From Tissues To Cellmentioning

confidence: 99%

The History and Use of Human Hepatocytes for the Treatment of Liver Diseases: The First 100 Patients

et al. 2014

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Artificial liver support at present and in the future

et al. 2006

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Liver failure is a fatal disease. Liver transplantation is the only established treatment for liver failure; however, donor shortages remain problematic. In the United States and Europe, artificial livers as a bridge to liver transplantation are being considered. In Japan, we have taken a different approach to the treatment of end-stage liver diseases because of the characteristics of the health-care insurance system, regulated by the government. Furthermore, cadaveric liver transplantations are unsuited to the social mores of Japanese culture. Practically speaking, we believe that plasma exchange (PE) and continuous hemodiafiltration (CHDF) are the most effective therapies for the treatment of liver failure, although randomized controlled studies are needed to determine their effects. Overall, we believe that the first line of treatment for liver failure should be PE and CHDF, and the second line should be bioartificial liver support. In the near future, we hope that both gene therapy and regenerative medicine will contribute to the development of a functional artificial liver.

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Cell Therapy of Liver Disease: From Hepatocytes to Stem Cells

Strom¹,

Ellis²

2011

Principles of Regenerative Medicine

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Multilocational hepatocyte transplantation for treatment of congenital ascorbic acid deficiency rats

Cited by 6 publications

References 1 publication

The History and Use of Human Hepatocytes for the Treatment of Liver Diseases: The First 100 Patients

The History and Use of Human Hepatocytes for the Treatment of Liver Diseases: The First 100 Patients

Artificial liver support at present and in the future

Cell Therapy of Liver Disease: From Hepatocytes to Stem Cells

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