In this article, Newton–Raphson optimization-based selective harmonic elimination pulse width modulation is investigated for open-loop control of flying capacitor multilevel inverter. Proposed control strategy has allowed giving up current and voltage measurement instrumentations and sensors used in case of closed loop–based control. Proposed control strategy generates accurate switching angles, capable to balance flying capacitor voltage and eliminate lower order harmonics considering load power factor variation. Algorithm performances are verified by simulation and experiments, and obtained results prove that proposed technique does effectively eliminate specific harmonics and balance capacitor voltages while getting inverter output voltage with desired number of levels.