Multijet electrospinning of conducting nanofibers from microfluidic manifolds

Srivastava, Yasmin; Márquez, Manuel; Thorsen, Todd

doi:10.1002/app.26810

Cited by 68 publications

(41 citation statements)

References 43 publications

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“…Advantages of this approach include ease of fabrication, flexible control over channel dimensions and geometry, and the potential for multiplexed, multijet electrospinning within a single microfluidic device. 19,25,27 The multilayer microfluidic electrospinning devices used in this study were molded from two-part ͑A:B͒ Sylgard 184 PDMS rubber ͑Dow Corning͒. Positive-relief photoresist molds, used as masters for the microchannel networks, were fabricated using standard lithographic procedures.…”

Section: Experiments and Resultsmentioning

confidence: 99%

“…While the fiber size distribution is quite high, it can be attributed to both characteristic electrospinning bending instabilities and coulombic repulsion between adjacent jets. 25 The higher-magnification SEM image ͓Fig. 2͑b͔͒ indicates that the single fiber exhibited a bundlelike structure with two small nanofibers bound together.…”

Section: Experiments and Resultsmentioning

confidence: 99%

“…While a few examples of multijet electrospinning have been reported, efforts to date have been restricted to the electrospinning of single phase, blends, composite, hollow, and core-sheath nanofibers. [21][22][23][24][25][26] …”

Section: Introductionmentioning

confidence: 99%

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Microfluidic electrospinning of biphasic nanofibers with Janus morphology

2009

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In this paper a method of electrospinning conducting and nonconducting biphasic Janus nanofibers using microfluidic polydimethylsiloxane ͑PDMS͒-based manifolds is described. Key benefits of using microfluidic devices for nanofiber synthesis include rapid prototyping, ease of fabrication, and the ability to spin multiple Janus fibers in parallel through arrays of individual microchannels. Biphasic Janus nanofibers of polyvinylpyrrolidone ͑PVP͒ + polypyrrole ͑PPy͒/PVP nanofibers with an average diameter of 250 nm were successfully fabricated using elastomeric microfluidic devices. Fiber characterization and confirmation of the Janus morphology was subsequently carried out using a combination of scanning electron microscopy, energy dispersion spectroscopy, and transmission electron microscopy.

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Section: Experiments and Resultsmentioning

confidence: 99%

Section: Experiments and Resultsmentioning

confidence: 99%

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Microfluidic electrospinning of biphasic nanofibers with Janus morphology

2009

Self Cite

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“…Huang et al have reported that nearly 100 different polymers have been electrospun into ultrafine fibers so far from either polymer solution or melt [55]. Srivastava et al have used microfluidic manifolds to simultaneously spin multiple jets [57] as well as to create core/sheath nanofibers [58]. Figure 1 shows a typical electrospinning setup, which consists of a syringe with a metal needle containing the polymer solution or melt, a metering pump as the feed rate control, a conductive (usually metal) collector, and a high voltage DC power supply.…”

Section: Electrospinning Processmentioning

confidence: 99%

Biodegradable Cell-Seeded Nanofiber Scaffolds for Neural Repair

Han

Cheung

2011

Polymers

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Central and peripheral neural injuries are traumatic and can lead to loss of motor and sensory function, chronic pain, and permanent disability. Strategies that bridge the site of injury and allow axonal regeneration promise to have a large impact on restoring quality of life for these patients. Engineered materials can be used to guide axonal growth. Specifically, nanofiber structures can mimic the natural extracellular matrix, and aligned nanofibers have been shown to direct neurite outgrowth and support axon regeneration. In addition, cell-seeded scaffolds can assist in the remyelination of the regenerating axons. The electrospinning process allows control over fiber diameter, alignment, porosity, and morphology. Biodegradable polymers have been electrospun and their use in tissue engineering has been demonstrated. This paper discusses aspects of electrospun biodegradable nanofibers for neural regeneration, how fiber alignment affects cell alignment, and how cell-seeded scaffolds can increase the effectiveness of such implants.

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“…So far, several efforts have been made to increase the production rate of nanofibers. For instance, modified single-needle [17,18], multi-needle [19][20][21][22][23][24][25][26][27], needleless systems [28][29][30][31][32][33][34], a plastic filter set-up [35] and forcespinning have been developed to enhance nanofiber production rate. Forcespinning TM or centrifuge spinning uses centrifugal force, rather than electrostatic force, as in the electrospinning process [36].…”

Section: Introductionmentioning

confidence: 99%

Experimental and numerical study on isolated and non-isolated jet behavior through centrifuge spinning system

Valipouri

Ravandi

Pishevar

et al. 2015

International Journal of Multiphase Flow

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This work presents a comparison between an isolated and a non-isolated curved liquid jet emerging from a rotating nozzle through centrifuge spinning system. In the centrifugal spinning process, a polymer solution has been pushed by the centrifugal force through small nozzle of a rapidly rotating cylindrical drum. Thereby thin fibers are formed and collected on a collector in the form of a web. Centrifuge spinning suffered from a strong air resistance which leads to a more deflected jet as well as its rapidly solvent evaporation resulting in thicker nanofibers. In this work, centrifuge spinning has been equipped by a rotating collector, whereas the fabrication process was skillfully sealed from ambient airflow. A comparison was drawn between the trajectory of Newtonian liquid jets fabricated by centrifuge spinning and air-sealed centrifuge spinning. The captured images of the liquid jet trajectory using a high speed camera showed that non-isolated liquid jets were more curved than isolated liquid jets due to air resistance. A pre-presented non-linear analysis of the Navier-Stokes equations was carried out and the numerical solutions were compared with the experiments.There was fairly good agreement between the isolated jet trajectory and the model-predicted one, but there were differences between the non-isolated jet trajectory and the simulation results. The non-isolated jet curved more compared to the others due to air drag. Also, the diameter of polymeric nanofibers was predicted and compared with experiments. Some qualitative agreement was found

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Multijet electrospinning of conducting nanofibers from microfluidic manifolds

Cited by 68 publications

References 43 publications

Microfluidic electrospinning of biphasic nanofibers with Janus morphology

Microfluidic electrospinning of biphasic nanofibers with Janus morphology

Biodegradable Cell-Seeded Nanofiber Scaffolds for Neural Repair

Experimental and numerical study on isolated and non-isolated jet behavior through centrifuge spinning system

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