Abstract:Bacterial diheme peroxidases (bCCP) act in the detoxification of reactive oxygen species by reduction of peroxide to water. The substrate H2O2 is bound to the free axial position of a heme cofactor, and in a first step, one H2O molecule is released, while the remaining oxygen is stabilized as a metastable FeivO intermediate that awaits further reduction. Unlike other peroxidases, however, bCCPs employ two heme cofactors, each of which can provide one electron to form the oxoferryl species, so that the formati… Show more
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