2022
DOI: 10.3389/fgene.2021.773725
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Abstract: In recent years, the herpes virus infectious hypothesis for Alzheimer’s disease (AD) has gained support from an increasing number of researchers. Herpes simplex virus (HSV) is a potential risk factor associated with AD. This study assessed whether HSV has a causal relationship with AD using a two-sample Mendelian randomization analysis model. Six single-nucleotide polymorphisms (SNPs) associated with HSV-1 and thirteen SNPs associated with HSV-2 were used as instrumental variables in the MR analysis. We estima… Show more

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Cited by 9 publications
(6 citation statements)
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“…Second, though we used the F ‐statistic to define strong instruments, distortion caused by weak instruments may appear. This might be because our instrumental variables were selected based on the relaxed significance threshold 1 × 10 −5 rather than classical 5 × 10 −8 in the forward MR to guarantee the existence of IVs for all research subjects 50 . Third, limited IVs caused by limited sample size, especially for HSV IgG, might affect the statistical power of the causal estimates.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Second, though we used the F ‐statistic to define strong instruments, distortion caused by weak instruments may appear. This might be because our instrumental variables were selected based on the relaxed significance threshold 1 × 10 −5 rather than classical 5 × 10 −8 in the forward MR to guarantee the existence of IVs for all research subjects 50 . Third, limited IVs caused by limited sample size, especially for HSV IgG, might affect the statistical power of the causal estimates.…”
Section: Discussionmentioning
confidence: 99%
“…rather than classical 5 × 10 −8 in the forward MR to guarantee the existence of IVs for all research subjects 50. Third, limited IVs caused by limited sample size, especially for HSV IgG, might affect the statistical power of the causal estimates.…”
mentioning
confidence: 99%
“…We performed a replicate MR analysis for significant results and a meta‐analysis to explore the combined effect. All statistical analyses were performed by using the “TwoSampleMR” (Hemani et al., 2018), “MR‐PRESSO” (Verbanck et al., 2018) and “RadialMR” packages (Zhang et al., 2021) in R (version 4.2.1.) and Reviewer Manager software (Version 5.4.1).…”
Section: Methodsmentioning
confidence: 99%
“…This method has gained traction over the last 2 decades due to the proliferation and accessibility of genotype data. [200][201][202][203] MR leverages germline genetic variants as surrogates, benefiting from their independence from environmental influences or disease processes. This allows MR to mitigate confounding effects, enhance the connection between exposures and outcomes, and circumvent issues of reverse causality.…”
Section: Multiple Sclerosismentioning
confidence: 99%