2019
DOI: 10.1016/j.taap.2018.12.021
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Abstract: While Δ 9 -tetrahydrocannabinol (THC) has been widely studied in the realm of developmental and reproductive toxicology, few studies have investigated potential toxicities from a second widely used cannabis constituent, cannabidiol (CBD). CBD is popularized for its therapeutic potential for reducing seizure frequencies in epilepsy. This study investigated developmental origins of health and disease (DOHaD) via multigenerational gene expression patterns, behavior phenotypes, and reproductive fitness of a subseq… Show more

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Cited by 28 publications
(35 citation statements)
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“…Previous research in our laboratory established that embryonic exposure to high doses of CBD (≥ 2 μM) caused larval developmental teratogenicity, and altered the expression of several genes (Carty et al 2018). Importantly, lower doses that did not induce teratogenicity and fall within the lower end of the human therapeutic range resulted in long-term changes in fecundity (Carty et al 2019). Negative effects of high CBD exposure are also recapitulated in mammalian models.…”
Section: Introductionmentioning
confidence: 81%
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“…Previous research in our laboratory established that embryonic exposure to high doses of CBD (≥ 2 μM) caused larval developmental teratogenicity, and altered the expression of several genes (Carty et al 2018). Importantly, lower doses that did not induce teratogenicity and fall within the lower end of the human therapeutic range resulted in long-term changes in fecundity (Carty et al 2019). Negative effects of high CBD exposure are also recapitulated in mammalian models.…”
Section: Introductionmentioning
confidence: 81%
“…Beginning at~6 hpf, zebrafish embryos were exposed to sublethal concentrations (Carty et al 2018), namely, 0.02, 0.1, and 0.5 μM (0.006, 0.03, 0.15 mg/L) CBD, or 0.05% DMSO control water (0.6 mL water:fish) in static conditions without water changes until 96 hpf. Measured concentrations for 0.15 mg/L CBD were 0.07 ± 0.05 mg/L CBD as reported in (Carty et al 2019). The methodology of exposure and rearing of the F0 generation are described in (Carty et al 2019).…”
Section: Zebrafish Care and Exposurementioning
confidence: 96%
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“…In addition to mammalian animal models, studies of fish animal models have found BDNF mRNA expression widely abundant throughout the brains of 7-day old zebrafish larvae (Cacialli et al, 2016). The application of exogenous cannabinoids, namely THC and cannabidiol (CBD), to developing zebrafish interrupted regular neurogenesis during key developmental stages accompanied by affected production of BDNF (Carty et al, 2019). Taken together, this suggests a universal role for BDNF and eCB signalling in the development of neural networks throughout the animal kingdom that was established early on in our phylogenetic history.…”
Section: The Role Of Bdnf and The Ecb System In Embryonic And Developmentioning
confidence: 99%