Multifunctional Yolk−Shell Nanoparticles: A Potential MRI Contrast and Anticancer Agent

Gao, Jinhao; Liang, Gaolin; Cheung, J. T.; Xiao, Xiaohui; Kuang, Yi; Zhao, Fan; Zhang, Bei; Zhang, Xixiang; Wu, Ed X.; Xu, Bing

doi:10.1021/ja803920b

Cited by 352 publications

(315 citation statements)

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“…[43][44][45][46][47] We have recently demonstrated that particles of superior stability are obtained using PEG anchored with nitrocatechols 43,48 and thus all the results shown in this paper were obtained using Fe 3 O 4 NPs stabilized by PEG-nitroDOPA shells of different thickness.…”

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confidence: 76%

Adsorption of core-shell nanoparticles at liquid–liquid interfaces

et al. 2011

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The use of nanoparticles as building blocks for the self-assembly of functional materials has been rapidly increasing in recent years. In particular, two-dimensional materials can be effectively selfassembled at liquid interfaces thanks to particle localization and mobility at the interface in combination with tailoring of specific interactions. Many recent advances have been made in the understanding of the adsorption and assembly at liquid interfaces of small hydrophobic nanoparticles stabilized by short-chain rigid dispersants but the corresponding studies on core-shell nanoparticles sterically stabilized by extended hydrophilic polymer brushes are presently missing. Such particles offer significant advantages in terms of fabrication of functional, responsive and bio-compatible materials. We present here a combination of experimental and numerical data together with an intuitive and simple model aimed at elucidating the mechanisms governing the adsorption of iron oxide nanparticles (5-10 nm) stabilized by low molecular weight poly(ethylene glycol) (1.5-10 kDa). We show that the adsorption dynamics and the structure of the final assembly depend on the free energy of the particles at the interface and discuss the thermodynamics of the adsorption in terms of the polymer solubility in each phase.

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confidence: 76%

Adsorption of core-shell nanoparticles at liquid–liquid interfaces

et al. 2011

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“…Magnetic focusing can be exploited to concentrate the IONPs in the desired area such that the accumulation of IONPs can exaggerate the EPR eff ect. In addition, the iron-oxide core can be engineered to liberate toxic organic compounds by the introduction of platinum inside the IONP cores [77].…”

Section: Drug and Gene Deliverymentioning

confidence: 99%

The design and utility of polymer-stabilized iron-oxide nanoparticles for nanomedicine applications

et al. 2010

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Iron-oxide nanoparticles (IONPs) represent a significant class of inorganic nanomaterial that is contributing to the current revolution in nanomedicine [1][2]. Their unique physical properties, including high surface area to volume ratios and superparamagnetism, confer useful attributes for medical applications such as magnetic resonance imaging (MRI), drug and gene delivery, tissue engineering and bioseparation [3].Two distinct classes of superparamagnetic IONP-based materials are currently used for medical applications: superparamagnetic iron-oxide (SPIO) nanoparticles with a mean particle diameter of 50-100 nm, and ultra-small superparamagnetic iron-oxide (USPIO) nanoparticles with a size below 50 nm. Th ese two classes of IONPs have been studied widely for medical applications, particularly as the next (potential) generation of MRI contrast agents. Th ey are also seen as potential vectors for drug and gene delivery. Th e biodistribution of these nanoparticles can be altered by the application of an external magnetic fi eld; they also have potential applications in hyperthermia therapy as some magnetic particles can heat up under the infl uence of a localized high-frequency magnetic fi eld.Th e intent of this review is to present recent advances in the synthesis of IONPs and their subsequent stabilization in biological fluids using polymers, focusing on the current strategies used to graft polymers onto IONPs surfaces (see Figure 1) and the diff erent types of polymers used. Th e additional properties conferred by the polymers, such as targeting, eff ects on biodistribution and pharmacokinetics, are also discussed, and the main applications of IONPs are reviewed. Synthesis and properties of iron-oxide nanoparticlesSPIO and USPIO nanoparticles are the most extensively studied magnetic nanoparticles for biomedical applications as they are both biocompatible and easy to synthesize. Both are composed of ferrite nanocrystallites of magnetite (Fe 3 O 4 ) or maghemite (Fe 2 O 3 , γ). Over the last ten years, there has been an explosion of interest in these materials and this has been reflected in a large number of recent publications describing the synthesis and modifi cation of hybrid IONPs. In this review, we focus on the polymer modifi cation of the nanoparticles, and provide only minimal information on the inorganic synthesis of IONPs. For more detailed information on IONP synthesis, readers are referred to other reviews [3,4]. The design and utility of polymer-stabilized iron-oxide nanoparticles for nanomedicine applicationsCyrille Boyer 1 * , Michael R. Whittaker 1 , Volga Bulmus 2 , Jingquan Liu 1 and Thomas P. Davis 1 * University of New South Wales, AustraliaOver the past decade, the synthesis of superparamagnetic nanoparticles, especially iron-oxide nanoparticles (IONPs), has been researched intensively for many high-technology applications, including enhanced storage media, biosensing and medical applications. In medicine, IONPs are used as contrast agents in magnetic resonance imaging and in hyperthermia...

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“…[16][17][18] The magnetization of FePt NPs up to ∼1000 emu cc −1 is higher than that of commonly used iron oxide (approximately 300-400 emu cc −1 ) and comparable to that of Co (∼1400 emu cc −1 ) and Fe (∼1700 emu cc −1 ), making them valuable candidates for magnetic resonance imaging. [19][20][21][22] It has been reported that FePt NPs display stronger contrast enhancement when compared with several commercial magnetic resonance imaging contrast agents (Feridex, MION, and Sinerem; AMAG Pharmaceuticals Inc., Lexington, MA, MGH Center of Molecular Imaging Research, Boston, MA, and Guerbet Group, Villepinte, France, respectively) according to their apparent transverse relaxivity values. 19,20 Therefore, FePt NPs can serve as dual modality contrast agents for molecular CT (computed tomography molecular imaging or MRI (magnetic resonance imaging) in vitro and in vivo after engineering their surfaces with functional molecules.…”

Section: Introductionmentioning

confidence: 99%

“…[19][20][21][22] It has been reported that FePt NPs display stronger contrast enhancement when compared with several commercial magnetic resonance imaging contrast agents (Feridex, MION, and Sinerem; AMAG Pharmaceuticals Inc., Lexington, MA, MGH Center of Molecular Imaging Research, Boston, MA, and Guerbet Group, Villepinte, France, respectively) according to their apparent transverse relaxivity values. 19,20 Therefore, FePt NPs can serve as dual modality contrast agents for molecular CT (computed tomography molecular imaging or MRI (magnetic resonance imaging) in vitro and in vivo after engineering their surfaces with functional molecules. 21 Of particular interest, superparamagnetic FePt NPs have been derived from the anticancer activity of FePt NPs.…”

Section: Introductionmentioning

confidence: 99%

“…Both FePt@CoS 2 and FePt@Fe 2 O 3 yolkshell NPs display a much lower IC 50 on HeLa cells than that of cisplatin, according to MTT assay. 19,23 Additionally, FePt NPs significantly suppress the proliferation of various tumor cells, such as human ovarian cancer cells (A2780), human epithelial carcinoma cells (A431), human breast cancer cells (Sk-Br3), and human embryonic kidney cells (HEK-293). 24 Thus, superparamagnetic FePt NPs could be considered good candidates for developing multi-functional nanomedicines for the diagnosis and therapy of malignant gliomas.…”

Section: Introductionmentioning

confidence: 99%

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Influences of surface coatings and components of FePt nanoparticles on the suppression of glioma cell proliferation

Sun¹,

Chen²,

Chen³

et al. 2012

IJN

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Malignant gliomas are primary brain tumors with high rates of morbidity and mortality; they are the fourth most common cause of cancer death. Novel diagnostic and therapeutic techniques based on nanomaterials provide promising options in the treatment of malignant gliomas. In order to evaluate the potential of FePt nanoparticles (NPs) for malignant glioma therapy, FePt NPs with different surface coatings and components were tunably synthesized using oleic acid/oleylamine (OA/OA) and cysteines (Cys) as the capping agents, respectively. The samples were characterized using X-ray diffraction, transmission electron microscopy (TEM), X-ray photon spectroscopy, Fourier transform infrared spectroscopy, atomic absorption spectrum, and zeta potential. The influence of the surface coatings and components of the FePt NPs on the proliferation of glioma cells was assessed through MTT assay and TEM observation using three typical glioma cell lines (glioma U251 cells, astrocytoma U87 cells, and neuroglioma H4 cells) as in vitro models. The results showed that the proliferation of glioma cells was significantly suppressed by lipophilic FePt-OA/OA NPs in a time-and/or dose-dependent manner, while no or low cytotoxic effects were detected in the case of hydrophilic FePt-Cys NPs. The IC 50 value of FePt-OA/OA NPs on the three glioma cell lines was approximately 5-10 µg mL −1 after 24 hours' incubation. Although the cellular uptake of FePt NPs was confirmed regardless of the surface coatings and components of the FePt NPs, the suppression of FePt NPs on glioma cell proliferation was dominantly determined by their surface coatings rather than their components.Therefore, these results demonstrate that, through engineering of the surface coating, FePt NPs can potentially be developed as novel therapeutic agents for malignant gliomas.

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Multifunctional Yolk−Shell Nanoparticles: A Potential MRI Contrast and Anticancer Agent

Cited by 352 publications

References 50 publications

Adsorption of core-shell nanoparticles at liquid–liquid interfaces

Adsorption of core-shell nanoparticles at liquid–liquid interfaces

The design and utility of polymer-stabilized iron-oxide nanoparticles for nanomedicine applications

Influences of surface coatings and components of FePt nanoparticles on the suppression of glioma cell proliferation

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