Multifunctional near-infrared-emitting nano-conjugates based on gold clusters for tumor imaging and therapy

Chen, Haiyan; Li, Bowen; Ren, Xueyan; Li, Shengnan; Ma, Yuxiang; Cui, Sisi; Gu, Yueqing

doi:10.1016/j.biomaterials.2012.08.034

Cited by 99 publications

(67 citation statements)

References 43 publications

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“…61 Au-Met-MPA, which was constructed using Au NCs, methionine (Met), and MPA, also exhibited NIR tumor-targeting capability with low cytotoxicity. 62 Despite advances in nanotechnology, the strategy of incorporating multiple materials and/or agents into one GNP with optimal properties remains challenging. Intractable problems concerning purity, solubility, stability in physiological environments, and the extreme synthetic process of these probes limit their imaging applications in a larger scope.…”

Section: Gold Nanostructuresmentioning

confidence: 99%

Near-infrared fluorescent probes in cancer imaging and therapy: an emerging field

Yi¹,

Wang²,

Qin³

et al. 2014

IJN

209

147

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Near-infrared fluorescence (NIRF) imaging is an attractive modality for early cancer detection with high sensitivity and multi-detection capability. Due to convenient modification by conjugating with moieties of interests, NIRF probes are ideal candidates for cancer targeted imaging. Additionally, the combinatory application of NIRF imaging and other imaging modalities that can delineate anatomical structures extends fluorometric determination of biomedical information. Moreover, nanoparticles loaded with NIRF dyes and anticancer agents contribute to the synergistic management of cancer, which integrates the advantage of imaging and therapeutic functions to achieve the ultimate goal of simultaneous diagnosis and treatment. Appropriate probe design with targeting moieties can retain the original properties of NIRF and pharmacokinetics. In recent years, great efforts have been made to develop new NIRF probes with better photostability and strong fluorescence emission, leading to the discovery of numerous novel NIRF probes with fine photophysical properties. Some of these probes exhibit tumoricidal activities upon light radiation, which holds great promise in photothermal therapy, photodynamic therapy, and photoimmunotherapy. This review aims to provide a timely and concise update on emerging NIRF dyes and multifunctional agents. Their potential uses as agents for cancer specific imaging, lymph node mapping, and therapeutics are included. Recent advances of NIRF dyes in clinical use are also summarized.

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Section: Gold Nanostructuresmentioning

confidence: 99%

Near-infrared fluorescent probes in cancer imaging and therapy: an emerging field

Yi¹,

Wang²,

Qin³

et al. 2014

IJN

209

147

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“…Determination of Minimum InhibitoryConcentrations of CAP-UBI[29][30][31][32][33][34][35][36][37][38][39][40][41] …”

mentioning

confidence: 99%

Bacteria-Targeting Conjugates Based on Antimicrobial Peptide for Bacteria Diagnosis and Therapy

et al. 2015

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Chloramphenicol (CAP) is one of the most effective antimicrobial agents, but its therapeutic efficacy is greatly limited by its nonspecific distribution and consequent side effects in neutrophils. Targeting to the infection sites, and thus restricting CAP nonselective delivery, provides an alternative way to overcome this limitation. The antibacterial peptide fragment UBI29-41 was identified to have a high bacterial affinity. However, no research so far has been carried out to utilize UBI29-41 as a ligand for bacteria-targeting therapies. In this Article, we first labeled a near-infrared fluorescent dye (ICG02) with UBI29-41 to investigate its targeting capability in different bacteria (S. aureus, E. coli, and P. auruginosa) and bacteria-infected mouse models. Subsequently, UBI29-41 was conjugated with the typical antibiotic (CAP) through the linker glutaric anhydride to form the conjugate CAP-UBI29-41 for the bacteria-targeting therapy. In vitro studies demonstrated the enhanced antibacterial effects of CAP-UBI29-41 on S. aureus and E.coil. Meanwhile, the toxicity of CAP-UBI29-41 on normal cells decreased distinctly in comparison with CAP. Most importantly, CAP-UBI29-41 exhibited more favorable antibacterial efficacy than CAP in bacteria-bearing mouse models. All these results demonstrated that UBI29-41 is an ideal targeting ligand to construct antibacterial agents for bacteria-targeting therapy.

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“…[65] Interestingly, few reports have recently described the unique nuclei staining properties of AuNCs, [66,67] which could allow the study of important biological processes such as mitosis. [67] This nuclei targeting is also the origin of several drug delivery studies, [68][69][70][71] such as DOX delivery via AuNC@BSA combined with two-photon imaging. [72] AuNCs were also covalently grafted on non-porous silica NPs for cytosol imaging and reactive oxygen species detection via the quenching of the gold fluorescence, [73] however, AuNCs were not combined with MSN.…”

Section: Accepted M Manuscriptmentioning

confidence: 99%

“…The organized long-ranged mesoporosity was evidenced by small-angle X-ray diffraction (XRD) patterns in MSN and MSN-NH 2 with the intense peak at 2 degrees, as the satellites between 4 and 5 degrees ( Figure S2). AuNC@BSA exhibited the absorption band of BSA (λ max = 390 nm) arising from aromatic amino acids (tryptophan, tryrosine), [71] as well as the AuNCs plasmon band (λ max = 496 nm, Fig S6). The strong broad emission of the clusters from the red to the NIR (550 < λ em < 800 nm, λ max = 645 nm) ( Figure S6A).…”

Section: Preparation Of Msn-aunc@bsa Nanocarriersmentioning

confidence: 99%

“…[60] The conjugation of BSA to the nanoclusters was confirmed FTIR analysis with the primary amine scissoring N-H at 1538 cm -1 , the typical amide I C=O intense mode at 1659 cm -1 , as well as the N-H stretching mode at 3066 cm -1 ( Figure S7). [71] The MSN-AuNC@BSA nanocarrier was then designed and fully characterized. The design principle of the system is illustrated in Figure 1B Figure S8).…”

Section: Preparation Of Msn-aunc@bsa Nanocarriersmentioning

confidence: 99%

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Protein-gold clusters-capped mesoporous silica nanoparticles for high drug loading, autonomous gemcitabine/doxorubicin co-delivery, and in-vivo tumor imaging

Croissant¹,

Zhang

Alsaiari

et al. 2016

Journal of Controlled Release

150

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, Protein-gold clusters-capped mesoporous silica nanoparticles for high drug loading, autonomous gemcitabine/doxorubicin co-delivery, and in-vivo tumor imaging, Journal of Controlled Release (2016Release ( ), doi: 10.1016Release ( /j.jconrel.2016 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT

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Multifunctional near-infrared-emitting nano-conjugates based on gold clusters for tumor imaging and therapy

Cited by 99 publications

References 43 publications

Near-infrared fluorescent probes in cancer imaging and therapy: an emerging field

Near-infrared fluorescent probes in cancer imaging and therapy: an emerging field

Bacteria-Targeting Conjugates Based on Antimicrobial Peptide for Bacteria Diagnosis and Therapy

Protein-gold clusters-capped mesoporous silica nanoparticles for high drug loading, autonomous gemcitabine/doxorubicin co-delivery, and in-vivo tumor imaging

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