Multifunctional Nanoparticles Composed of A Poly( dl‐lactide‐coglycolide) Core and A Paramagnetic Liposome Shell for Simultaneous Magnetic Resonance Imaging and Targeted Therapeutics

Abstract

A multifunctional nanoscale platform that is self‐assembled from a hydrophobic poly( dl‐lactide‐coglycolide)(PLGA) core and a hydrophilic paramagnetic‐folate‐coated PEGylated lipid shell (PFPL; PEG=polyethylene glycol) is designed for simultaneous magnetic resonance imaging (MRI) and targeted therapeutics. The nanocomplex has a well‐defined core‐shell structure which is studied using confocal laser scanning microscopy (CLSM). The paramagnetic diethylenetriaminepentaacetic acid‐gadolinium (DTPA‐Gd) chelated to the shell layer exhibits significantly higher spin–lattice relaxivity (r1) than the clinically used small‐molecular‐weight MRI contrast agent Magnevist®. The PLGA core serves as a nanocontainer to load and release the hydrophobic drugs. From a drug‐release study, it is found that the modification of the PLGA core with a polymeric liposome shell can be a useful tool for reducing the drug‐release rate. Cellular uptake of folate nanocomplex is found to be higher than that of non‐folate‐nanocomplex due to the folate‐binding effect on the cell membrane. This work indicates that the multifunctional platform with combined characteristics applicable to MRI and drug delivery may have great potential in cancer chemotherapy and diagnosis.

Magnetic Resonance Imaging (MRI) Contrast Agents for Tumor Diagnosis

“…That system showed an r 1 value of 18.14 mM −1 s −1 and a long retention time of up to 20 hours [89]. Other theranostic systems with higher r 1 values have also been reported with FA as targeting moiety and doxorubicin as drug [90][91][92].…”

Enhancing Transversal Relaxation for Magnetite Nanoparticles in MR Imaging Using Gd3+-Chelated Mesoporous Silica Shells

“…The Gd 3+ -chelated Fe 3 O 4 @SiO 2 nanoparticles have a positive surface charge of +17.4 mV. XPS analysis (Figure S7) shows a broad band in the range of 135–140 eV corresponding to Gd 4d , which indicates the presence of Gd 3+ ions in DOTA-functionalized Fe 3 O 4 @SiO 2 compared with Fe 3 O 4 @SiO 2 nanoparticles. No detection of an Fe signal is consistent with core–shell nanostructures.…”

Hybrid PLGA-Organosilica Nanoparticles with Redox-Sensitive Molecular Gates

“…Similar approaches of PLGA core–shell systems have been developed with organic − or inorganic − coatings, with significant improvement in the controlled release of the transported molecule. Nevertheless, the main benefit of our model is that it is potentially sensitive to intracellular redox mechanisms, as those mediated by protein reductases or glutathione …”