Multifunctional magnetic iron oxide nanoparticles: an advanced platform for cancer theranostics

Zhao, Shengzhe; Yu, Xujiang; Qian, Yuna; Chen, Wei; Shen, Jianliang

doi:10.7150/thno.42564

Cited by 231 publications

(126 citation statements)

References 219 publications

Supporting

Mentioning

124

Contrasting

Unclassified

Order By: Relevance

“…Of these three methods, the chemical method is most preferred due to their easiness, less time taking and requirement of less expensive instrument. By means of chemical routes, IONPs have been successfully synthesized by co-precipitation method [19], solvothermal method [27] microemulsion method [28], sol-gel method [29], chemical vapor deposition method [30] and sonochemical method [23,31]. However, when it comes to the requirement of an amorphous nanoparticles with a better control of the morphology then sonochemical is the preferred method [32].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Amorphous Iron Oxide Nanoparticles by the Sonochemical Method and Their Application for the Remediation of Heavy Metals from Wastewater

et al. 2020

View full text Add to dashboard Cite

Nanoparticles have gained huge attention in the last decade due to their applications in electronics, medicine, and environmental clean-up. Iron oxide nanoparticles (IONPs) are widely used for the wastewater treatment due to their recyclable nature and easy manipulation by an external magnetic field. Here, in the present research work, iron oxide nanoparticles were synthesized by the sonochemical method by using precursors of ferrous sulfate and ferric chloride at 70 °C for one hour in an ultrasonicator. The synthesized iron oxide nanoparticles were characterized by diffraction light scattering (DLS), Fourier transform infrared spectroscopy (FTIR), Raman spectroscopy, X-ray diffraction (XRD), field-emission scanning electron microscopy (FESEM), electron diffraction spectroscopy (EDS), high-resolution transmission electron microscopy (HRTEM) and vibrating sample magnetometer (VSM). The FTIR analysis exhibits characteristic absorption bands of IONPs at 400–800 cm−1, while the Raman spectra showed three characteristic bands at 273, 675, and 1379 cm−1 for the synthesized IONPs. The XRD data revealed three major intensity peaks at two theta, 33°, 35°, and 64° which indicated the presence of maghemite and magnetite phase. The size of the spherical shaped IONPs was varying from 9–70 nm with an average size of 38.9 nm while the size of cuboidal shaped particle size was in microns. The purity of the synthesized IONPs was confirmed by the EDS attached to the FESEM, which clearly show sharp peaks for Fe and O, while the magnetic behavior of the IONPs was confirmed by the VSM measurement and the magnetization was 2.43 emu/g. The batch adsorption study of lead (Pb) and chromium (Cr) from 20% fly ash aqueous solutions was carried out by using 0.6 mg/100 mL IONPs, which exhibited maximum removal efficiency i.e., 97.96% and 82.8% for Pb2+ and Cr ions, respectively. The fly ash are being used in making cements, tiles, bricks, bio fertilizers etc., where the presence of fly ash is undesired property which has to be either removed or will be brought up to the value of acceptable level in the fly ash. Therefore, the synthesized IONPs, can be applied in the elimination of heavy metals and other undesired elements from fly ash with a short period of time. Moreover, the IONPs that have been used as a nanoadsorbent can be recovered from the reaction mixture by applying an external magnetic field that can be recycled and reused. Therefore, this study can be effective in all the fly ash-based industries for elimination of the undesired elements, while recyclability and reusable nature of IONPs will make the whole adsorption or elimination process much economical.

show abstract

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Amorphous Iron Oxide Nanoparticles by the Sonochemical Method and Their Application for the Remediation of Heavy Metals from Wastewater

et al. 2020

View full text Add to dashboard Cite

show abstract

“…While MRI provides excellent soft-tissue contrast and high image resolution, it suffers from low sensitivity in differentiating healthy and malignant tissues 28 . Multimodal imaging has been used to obtain complementary structural/functional/molecular information and draw a more comprehensive diagnostic map describing the complex dynamics of tumor pathogenesis 72 . For instance, integration of MRI with imaging modalities that provide higher sensitivity, such as near-infrared fluorescence (NIRF) 73 and PET imaging 74 , and the use of multimodal imaging contrast agents significantly reduces data processing time and enhances diagnostic accuracy 75 .…”

Section: Mri-guided Nanoparticles For Drug Deliverymentioning

confidence: 99%

MRI-traceable theranostic nanoparticles for targeted cancer treatment

Anani¹,

Rahmati²,

Nayer³

et al. 2021

Theranostics

View full text Add to dashboard Cite

Current cancer therapies, including chemotherapy and radiotherapy, are imprecise, non-specific, and are often administered at high dosages - resulting in side effects that severely impact the patient's overall well-being. A variety of multifunctional, cancer-targeted nanotheranostic systems that integrate therapy, imaging, and tumor targeting functionalities in a single platform have been developed to overcome the shortcomings of traditional drugs. Among the imaging modalities used, magnetic resonance imaging (MRI) provides high resolution imaging of structures deep within the body and, in combination with other imaging modalities, provides complementary diagnostic information for more accurate identification of tumor characteristics and precise guidance of anti-cancer therapy. This review article presents a comprehensive assessment of nanotheranostic systems that combine MRI-based imaging (T1 MRI, T2 MRI, and multimodal imaging) with therapy (chemo-, thermal-, gene- and combination therapy), connecting a range of topics including hybrid treatment options ( e.g. combined chemo-gene therapy), unique MRI-based imaging ( e.g. combined T1-T2 imaging, triple and quadruple multimodal imaging), novel targeting strategies ( e.g. dual magnetic-active targeting and nanoparticles carrying multiple ligands), and tumor microenvironment-responsive drug release ( e.g. redox and pH-responsive nanomaterials). With a special focus on systems that have been tested in vivo , this review is an essential summary of the most advanced developments in this rapidly evolving field.

show abstract

“…After surface modification, they have the abilities to (1) encapsulate multiple therapy molecules, like gene, protein, chemical drugs to achieve multi-drug cooperation therapy; (2) deliver drugs to target sites to increase drug concentration in disease site; (3) release loaded drugs according to various stimuli conditions of disease site. There have been FDA-approved INOPs [ 149 , 150 ]. For example, Feraheme ® has been approved for iron deficiency anemia in adults [ 4 ], which show advantages over other nanoparticles as a component of human body.…”

Section: Conclusion and Prospectionmentioning

confidence: 99%

Surface Modification of Iron Oxide-Based Magnetic Nanoparticles for Cerebral Theranostics: Application and Prospection

Lü

et al. 2020

Nanomaterials

View full text Add to dashboard Cite

Combining diagnosis with therapy, magnetic iron oxide nanoparticles (INOPs) act as an important vehicle for drug delivery. However, poor biocompatibility of INOPs limits their application. To improve the shortcomings, various surface modifications have been developed, including small molecules coatings, polymers coatings, lipid coatings and lipopolymer coatings. These surface modifications facilitate iron nanoparticles to cross the blood-brain-barrier, which is essential for diagnosis and treatments of brain diseases. Here we focus on the characteristics of different coated INOPs and their application in brain disease, particularly gliomas, Alzheimer’s disease (AD) and Parkinson’s disease (PD). Moreover, we summarize the current progress and expect to provide help for future researches.

show abstract

Multifunctional magnetic iron oxide nanoparticles: an advanced platform for cancer theranostics

Cited by 231 publications

References 219 publications

Synthesis and Characterization of Amorphous Iron Oxide Nanoparticles by the Sonochemical Method and Their Application for the Remediation of Heavy Metals from Wastewater

Synthesis and Characterization of Amorphous Iron Oxide Nanoparticles by the Sonochemical Method and Their Application for the Remediation of Heavy Metals from Wastewater

MRI-traceable theranostic nanoparticles for targeted cancer treatment

Surface Modification of Iron Oxide-Based Magnetic Nanoparticles for Cerebral Theranostics: Application and Prospection

Contact Info

Product

Resources

About