Multifunctional liquid metal-based nanoparticles with glycolysis and mitochondrial metabolism inhibition for tumor photothermal therapy

Ding, Xing‐Lan; Liu, Miao‐Deng; Cheng, Qian; Guo, Wenhui; Niu, Mei‐Ting; Huang, Qian‐Xiao; Zhang, Xuan; Zhang, Xian‐Zheng

doi:10.1016/j.biomaterials.2022.121369

Cited by 87 publications

(72 citation statements)

References 38 publications

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“…Upon specifically targeting CD44, the GNR/ HA-DC shows that it can sensitize tumor cells for photothermal therapy (PTT) by inhibiting anaerobic glycolysis. Besides, glucose is catalyzed by glucose oxidase (GOx), which could help convert glucose into gluconic acid and toxic H2O2, thereby inhibiting the process of glycolysis and enhancing tumor therapy (Fan et al, 2017;Ding et al, 2022). A multifunctional liquid metal-based nanoparticle attached with GOx and mineralizing calcium carbonate can inhibit glycolysis and mitochondrial metabolism to improve PTT efficiency (Ding et al, 2022).…”

Section: Aerobic Glycolysis and Mitochondrial Aerobic Respirationmentioning

confidence: 99%

“…Besides, glucose is catalyzed by glucose oxidase (GOx), which could help convert glucose into gluconic acid and toxic H2O2, thereby inhibiting the process of glycolysis and enhancing tumor therapy (Fan et al, 2017;Ding et al, 2022). A multifunctional liquid metal-based nanoparticle attached with GOx and mineralizing calcium carbonate can inhibit glycolysis and mitochondrial metabolism to improve PTT efficiency (Ding et al, 2022). Another report of nanoparticles, as a biocompatible nanocarrier, is used to deliver GOx, which also yields a significant anti-cancer effect (Fan et al, 2017).…”

Section: Aerobic Glycolysis and Mitochondrial Aerobic Respirationmentioning

confidence: 99%

“…However, cancer cells will compensate by increasing the other pathway to produce ATP if a single pathway of glucose metabolism is inhibited (Gottschalk et al, 2004). Therefore, many energy-depletion strategies of nanoparticles are designed to block both energy synthesis pathways synergistically (Ding et al, 2022;Dong et al, 2022). A cancer cell membrane camouflaged nanoinhibitor co-encapsulates OXPHOS inhibitor and glycolysis inhibitor for synergistically blocking two pathways that significantly suppress tumor growth (Dong et al, 2022), while some studies have confirmed that the strategy of targeting mitochondria can also reduce the occurrence and metastasis of tumors (Zhang et al, 2021b;Lin et al, 2021).…”

Section: Aerobic Glycolysis and Mitochondrial Aerobic Respirationmentioning

confidence: 99%

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Nanomedicines Targeting Metabolism in the Tumor Microenvironment

Ren

Zheng²,

Gao³

et al. 2022

Front. Bioeng. Biotechnol.

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Cancer cells reprogram their metabolism to meet their growing demand for bioenergy and biosynthesis. The metabolic profile of cancer cells usually includes dysregulation of main nutritional metabolic pathways and the production of metabolites, which leads to a tumor microenvironment (TME) having the characteristics of acidity, hypoxic, and/or nutrient depletion. Therapies targeting metabolism have become an active and revolutionary research topic for anti-cancer drug development. The differential metabolic vulnerabilities between tumor cells and other cells within TME provide nanotechnology a therapeutic window of anti-cancer. In this review, we present the metabolic characteristics of intrinsic cancer cells and TME and summarize representative strategies of nanoparticles in metabolism-regulating anti-cancer therapy. Then, we put forward the challenges and opportunities of using nanoparticles in this emerging field.

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Section: Aerobic Glycolysis and Mitochondrial Aerobic Respirationmentioning

confidence: 99%

Section: Aerobic Glycolysis and Mitochondrial Aerobic Respirationmentioning

confidence: 99%

Section: Aerobic Glycolysis and Mitochondrial Aerobic Respirationmentioning

confidence: 99%

See 1 more Smart Citation

Nanomedicines Targeting Metabolism in the Tumor Microenvironment

Ren

Zheng²,

Gao³

et al. 2022

Front. Bioeng. Biotechnol.

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“…Many cascade reactions have been elaborately designed. 21,22 Hybrid nanozyme-involving cascade reactions could effectively increase the catalytic performance. [23][24][25][26] Inspired by the natural biological system, the biomimetic membrane-mediated drug delivery system has received extensive attention in recent years.…”

Section: Introductionmentioning

confidence: 99%

“…Many cascade reactions have been elaborately designed. 21,22 Hybrid nanozyme-involving cascade reactions could effectively increase the catalytic performance. 23–26…”

Section: Introductionmentioning

confidence: 99%

Neutrophil membrane camouflaged hybrid nanozymes for enhanced starvation/photothermal tumor therapy

Han

Cui

et al. 2022

New J. Chem.

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Recent Advances in Calcium‐Based Anticancer Nanomaterials Exploiting Calcium Overload to Trigger Cell Apoptosis

Xiao

Bianco

et al. 2022

Adv Funct Materials

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Calcium ion is vital for the regulation of many cellular functions and serves as a second messenger in the signal transduction pathways. Once the intracellular Ca 2+ level exceeds the tolerance of cells (called Ca 2+ overload), oxidative stress, mitochondrial damage, and cell/mitochondria apoptosis happen. Therefore, Ca 2+ overload has started to be deeply exploited as a new strategy for cancer therapy due to its high efficiency and satisfactory safety. This review aims to highlight the recent development of Ca 2+ -based nanomaterials (such as Ca 3 (PO 4 ) 2 , CaCO 3 , CaO 2 , CaH 2 , CaS, and others) able to trigger intracellular Ca 2+ overload and apoptosis in cancer therapy. The intracellular mechanisms of varied Ca 2+ -based nanomaterials and the different types of strategies to enhance Ca 2+ overload are discussed in detail. Moreover, the design of more efficient Ca 2+ overload-mediated cancer therapies is prospected mainly based on 1) the enhanced cellular uptake by surface modification and morphology optimization of nanomaterials, 2) the accelerated Ca 2+ release from nanomaterials by increasing the intracellular H + level and by photothermal effect, and 3) the overload maintenance by Ca 2+ efflux inhibition, Ca 2+ influx promotion, or promoting Ca 2+ release from the endoplasmic reticulum.

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Multifunctional liquid metal-based nanoparticles with glycolysis and mitochondrial metabolism inhibition for tumor photothermal therapy

Cited by 87 publications

References 38 publications

Nanomedicines Targeting Metabolism in the Tumor Microenvironment

Nanomedicines Targeting Metabolism in the Tumor Microenvironment

Neutrophil membrane camouflaged hybrid nanozymes for enhanced starvation/photothermal tumor therapy

Recent Advances in Calcium‐Based Anticancer Nanomaterials Exploiting Calcium Overload to Trigger Cell Apoptosis

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