Multifunctional GO Hybrid Hydrogel Scaffolds for Wound Healing

Abstract

Hydrogel dressings have received extensive attention for the skin wound repair, while it is still a challenge to develop a smart hydrogel for adapting the dynamic wound healing process. Herein, we develop a novel graphene oxide (GO) hybrid hydrogel scaffold with adjustable mechanical properties, controllable drug release, and antibacterial behavior for promoting wound healing. The scaffold was prepared by injecting benzaldehyde and cyanoacetate group-functionalized dextran solution containing GO into a collection pool of histidine. As the GO possesses obvious photothermal behavior, the hybrid hydrogel scaffold exhibited an obvious stiffness decrease and effectively promoted cargo release owing to the breaking of the thermosensitive C=C double bond at a high temperature under NIR light. In addition, NIR-assisted photothermal antibacterial performance of the scaffold could be also achieved with the local temperature rising after irradiation. Therefore, it is demonstrated that the GO hybrid hydrogel scaffold with vascular endothelial growth factor (VEGF) encapsulation can achieve the adjustable mechanical properties, photothermal antibacterial, and angiogenesis during the wound healing process. These features indicated that the proposed GO hybrid hydrogel scaffold is potentially valuable for promoting wound healing and other biomedical application.

Designing self-healing hydrogels for biomedical applications

“…7b). 86 Such a scaffold revealed excellent biocompatibility and adjustable mechanical properties. Therefore, scaffolds loaded with vascular endothelial growth factors (VEGFs) can serve as hydrogel dressings for accelerating infected wound healing.…”

“…(b) The construction of a GO hybrid scaffold and its controllable drug release under NIR irradiation. Reproduced with permission 86. Copyright 2021, American Association for the Advancement of Science.…”

Fabricating biomimetic materials with ice‐templating for biomedical applications

“…The formed droplets are cross-linked by physically or chemically induced methods, resulting in monodisperse microfluidic hydrogel microspheres. 55 In a specific region of the microfluidic device, the controlled flow of the template solution is subjected to freezing conditions to induce ice templating. This can be achieved by introducing a temperature gradient or a cooling mechanism at the desired location.…”

“…The combination of microfluidics technology with the ice template method can provide a powerful platform for precise control and fabrication of complex hierarchical structures with well‐defined features. The formed droplets are cross‐linked by physically or chemically induced methods, resulting in monodisperse microfluidic hydrogel microspheres 55 . In a specific region of the microfluidic device, the controlled flow of the template solution is subjected to freezing conditions to induce ice templating.…”

Adhesive Composite Microspheres with Dual Antibacterial Strategies for Infected Wound Healing

“…[4][5][6] This brings serious health issues as well as economic burdens to patients. [7,8] Although a variety of wound dressings and patches have been developed and utilized for wound healing, [9][10][11] the bulk configuration of these materials restricts their applications in some deep and irregularly shaped wounds. [12] On the contrary, particles or powders are excellent alternatives that can be directly deposited in a wide range of wounds due to their flexible shape and tunable properties.…”