Multifunctional FeS<sub>2</sub>@SRF@BSA nanoplatform for chemo-combined photothermal enhanced photodynamic/chemodynamic combination therapy

Mao, Feng; Li, Meiting; Dai, Rui; Xiao, Shuting; Tang, Junjie; Chen, Baizhu; Liu, Jie

doi:10.1039/d1bm01597d

Cited by 20 publications

(10 citation statements)

References 34 publications

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“…The multifunctional nanoparticles are introduced with light/heat/physical dynamics for cancer therapy with synergistic therapy. [455][456][457] For example, Sun et al 458 constructed a multifunctional nanoplatform (AMIT) based on Au nanoclusters (AuNCs) coated with MnO 2 to codeliver ICG and the aptamer AS141 for targeting and image-guided PDT/CDT/PTT (Figure 5). The TME-responsive dissociation of MnO 2 could produce O 2 to enhance ICG-guided PDT and produce Mn 2+ for Fentonlike reaction-mediated CDT.…”

Section: Synergistic Therapymentioning

confidence: 99%

“…Due to the tissue penetration ability of PTT, CDT can promote the production of oxygen and can generate singlet oxygen with strong activity with PDT, achieving effective tumor killing effect in deep tissues. The multifunctional nanoparticles are introduced with light/heat/physical dynamics for cancer therapy with synergistic therapy 455‐457 . For example, Sun et al 458 .…”

Section: Application Strategies Of Multifunctional Nanoparticlesmentioning

confidence: 99%

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Multifunctional nanoparticle for cancer therapy

Wang

Zhang

Duan

et al. 2023

MedComm

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Cancer is a complex disease associated with a combination of abnormal physiological process and exhibiting dysfunctions in multiple systems. To provide effective treatment and diagnosis for cancer, current treatment strategies simultaneously focus on various tumor targets. Based on the rapid development of nanotechnology, nanocarriers have been shown to exhibit excellent potential for cancer therapy. Compared with nanoparticles with single functions, multifunctional nanoparticles are believed to be more aggressive and potent in the context of tumor targeting. However, the development of multifunctional nanoparticles is not simply an upgraded version of the original function, but involves a sophisticated system with a proper backbone, optimized modification sites, simple preparation method, and efficient function integration. Despite this, many well‐designed multifunctional nanoparticles with promising therapeutic potential have emerged recently. Here, to give a detailed understanding and analyzation of the currently developed multifunctional nanoparticles, their platform structures with organic or inorganic backbones were systemically generalized. We emphasized on the functionalization and modification strategies, which provide additional functions to the nanoparticle. We also discussed the application combination strategies that were involved in the development of nanoformulations with functional crosstalk. This review thus provides an overview of the construction strategies and application advances of multifunctional nanoparticles.

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Section: Synergistic Therapymentioning

confidence: 99%

Section: Application Strategies Of Multifunctional Nanoparticlesmentioning

confidence: 99%

Multifunctional nanoparticle for cancer therapy

Wang

Zhang

Duan

et al. 2023

MedComm

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“…The combination of Fenton-like reaction and PDT enhanced ROS production and antitumor effect. Similarly, Feng and his team designed and prepared a nanocomposite FeS 2 @SRF@BSA with bovine serum albumin (BSA) as a carrier to encapsulate FeS 2 NPs and SRF, for combining CDT, PTT and PDT to achieve trimodal synergistic tumor therapy Feng et al (2021) . In addition, the Z-scheme heterostructure possesses both narrow band gap and highly oxidative holes, which are helpful for inducing near-infrared photocatalytic oxygen production ( Mafa et al, 2021 ).…”

Section: Strategies For Nanoparticle-based Photocontrolled Deliverymentioning

confidence: 99%

Progress of Nanomaterials in Photodynamic Therapy Against Tumor

Chen

Huang

et al. 2022

Front. Bioeng. Biotechnol.

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Photodynamic therapy (PDT) is an advanced therapeutic strategy with light-triggered, minimally invasive, high spatiotemporal selective and low systemic toxicity properties, which has been widely used in the clinical treatment of many solid tumors in recent years. Any strategies that improve the three elements of PDT (light, oxygen, and photosensitizers) can improve the efficacy of PDT. However, traditional PDT is confronted some challenges of poor solubility of photosensitizers and tumor suppressive microenvironment. To overcome the related obstacles of PDT, various strategies have been investigated in terms of improving photosensitizers (PSs) delivery, penetration of excitation light sources, and hypoxic tumor microenvironment. In addition, compared with a single treatment mode, the synergistic treatment of multiple treatment modalities such as photothermal therapy, chemotherapy, and radiation therapy can improve the efficacy of PDT. This review summarizes recent advances in nanomaterials, including metal nanoparticles, liposomes, hydrogels and polymers, to enhance the efficiency of PDT against malignant tumor.

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“…Photodynamic reaction of FeS 2 @SRF@BSA under 808 nm laser produced 1 O 2 that was also a kind of ROS. Simultaneously, PTT also occurred at the same wavelength and then loaded with chemotherapeutic drugs SRF, so it finally cooperated to inhibit tumor growth ( Feng et al, 2022 ).…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Biomedical applications of iron sulfide-based nanozymes

Shan

et al. 2022

Front. Chem.

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Nanozymes have attracted great interest owing to their marvelous advantages, such as high stability, facile preparation, and high tunability. In particular, iron sulfide-based nanozymes (termed as ISNs), as one of the most researched nanomaterials with versatile enzyme-mimicking properties, have proved their potential in biomedical applications. In this review, we briefly summarize the classification, catalytic mechanisms of ISNs and then principally introduce ISNs’ biomedical applications in biosensors, tumor therapy, antibacterial therapy, and others, demonstrating that ISNs have promising potential for alleviating human health.

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Multifunctional FeS₂@SRF@BSA nanoplatform for chemo-combined photothermal enhanced photodynamic/chemodynamic combination therapy

Abstract: A FeS2@SRF@BSA nanoplatform was established for chemo-combined PTT enhanced PDT/CDT to achieve an “all-in-one” therapeutic agent. The designed nanoplatform greatly inhibited the tumor growth and achieved sufficient in vivo antitumor efficacy.

Cited by 20 publications

References 34 publications

Multifunctional nanoparticle for cancer therapy

Multifunctional nanoparticle for cancer therapy

Progress of Nanomaterials in Photodynamic Therapy Against Tumor

Biomedical applications of iron sulfide-based nanozymes

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Multifunctional FeS2@SRF@BSA nanoplatform for chemo-combined photothermal enhanced photodynamic/chemodynamic combination therapy

Abstract: A FeS2@SRF@BSA nanoplatform was established for chemo-combined PTT enhanced PDT/CDT to achieve an “all-in-one” therapeutic agent. The designed nanoplatform greatly inhibited the tumor growth and achieved sufficient in vivo antitumor efficacy.

Cited by 20 publications

References 34 publications

Multifunctional nanoparticle for cancer therapy

Multifunctional nanoparticle for cancer therapy

Progress of Nanomaterials in Photodynamic Therapy Against Tumor

Biomedical applications of iron sulfide-based nanozymes

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Product

Resources

About

Multifunctional FeS₂@SRF@BSA nanoplatform for chemo-combined photothermal enhanced photodynamic/chemodynamic combination therapy