Multifocal and multicentric breast cancer, is it time to think again?

Masannat, Yazan; Agrawal, Amit; Maraqa, Loaie; Fuller, Mairi; Down, Sue; Tang, Ssk; Pang, Da; Kontos, Michalis; Romics, László; Heys, Steven Darryll

doi:10.1308/rcsann.2019.0109

Cited by 30 publications

(23 citation statements)

References 32 publications

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“…Oncoplastic breast conservation surgery has been shown as a safe alternative to mastectomy and immediate breast reconstruction in selected patients based on the combined data of iBRA-2 and TeaM studies of 2916 patients (17). Further, the Scottish audits of oncoplastic breast conservations indicate that oncoplastic surgery can widen the indications for breast conservation, and provide good oncological outcome with low complication rates in our hands, hence it can be a reasonable alternative to mastectomy with immediate reconstruction (18)(19)(20)(21). One unit in Italy did offer immediate breast reconstruction even during the peak of the COVID-19 pandemic as it is indicated by Fragetti et al who reported 15 nipple-sparing mastectomies with immediate J o u r n a l P r e -p r o o f reconstruction done in 13 patients, although reconstructive techniques were not disclosed (14).…”

Section: Discussionmentioning

confidence: 99%

A prospective cohort study of the safety of breast cancer surgery during COVID-19 pandemic in the West of Scotland

Romics¹,

Doughty²,

Stallard³

et al. 2021

The Breast

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Section: Discussionmentioning

confidence: 99%

A prospective cohort study of the safety of breast cancer surgery during COVID-19 pandemic in the West of Scotland

Romics¹,

Doughty²,

Stallard³

et al. 2021

The Breast

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“…33 In a study by Massanat et al, they reported that BCT is not contraindicated in selected cases in MF/MC BCs. 34 In a similar study, Koppiker et al, proposed extreme oncoplasty (EO) instead of BCT in MF/MC cases. 35 Nijenhuis et al, reported that BCT may performed in most MF/MC cases.…”

Section: Resultsmentioning

confidence: 99%

“…37 Many authors have reported that BCT can be performed in some selected MF/MC cases. 20,34,37,38 However, in a study conducted by Edwards et al, 414 of 567 cases with BCT were reviewed, and histological tumor positive margin was found in 23%, and residual tumor was found in 61 cases. 39 In a study by Akbulut et al, miR-429 expression was shown to increase only in MBCs, while miR-182-5p and miR-96-5p expression increased in both MBC and UBCs.…”

Section: Resultsmentioning

confidence: 99%

“…In this study, a study with molecular markers in serum was not found in the MBCs in the literature. With ADMs in MBC patients; detection of tumor positivity at the surgical margin, 39,41 local recurrence, 21,39,40 possibility of another tumor focus in a different biological structure, 19,21,26 or a different stage, 25,29,30 the application rate of wrong or inappropriate treatment methods will decrease, 34,41 personalized treatment will be provided, 10,31 and the survival will be prolonged. 11,20,24,25 In a study conducted by Hu, the relationship between sociodemographic index (SDI), incidence of BC and mortality was examined.…”

Section: Resultsmentioning

confidence: 99%

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What is the effect of advanced diagnostic methods on sensitivity and survival in the multiple breast cancers? A systematic analysis and comparison

Acar¹,

Ozer²

2021

Asian J Med Sci

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The sensitivities of the advanced diagnostic methods appear to be higher than the conventional methods and do have the potential to prolong survival, in multiple (multifocal and multicenter) breast cancers. Thus, the aim of this study is to compare the sensitivities of advanced and conventional diagnostic methods and to reveal their effects on survival. The studies published about diagnosis and treatment methods in multiple breast cancer in literature were searched, analyzed, and the sensitivities obtained with advanced and conventional diagnostic methods were compared, and the results were evaluated statistically. The sensitivity obtained with the advanced diagnostic methods in multiple breast cancers was found to be significantly higher than the conventional methods (p <0.05). The high sensitivities obtained with advanced diagnostic methods were found to have a high potential for survivial prolongation in multiple breast cancers. The use of advanced diagnostic methods in breast cancer screening programs, the investigation of tumor foci with molecular methods, increases the rate of diagnosis in multiple breast cancers. In the treatment of multiple breast cancers, a personalized treatment plan is made with the diagnosis of the molecular structure of the tumor foci. Thus, the recurrence rates are reduced, the survival is prolonged.

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“…[1][2][3][4] In fact, we offer BCS for potentially poorer prognostic single-tumour patients or in-situ disease but continue to exclude larger or MFMC tumours. 5 The introduction of screening coupled with ultrasonography (US) and magnetic resonance imaging (MRI) has allowed us to more sensitively identify multifocal and multicentric cancers, making diagnosis of these "extreme" cases more common, thus surgical options more valid for debate. [6][7][8] Oncoplastic breast conservation (OBC) relies on applying plastic surgery principles within the context of sound oncological resection.…”

Section: Introductionmentioning

confidence: 99%

Extreme Oncoplasty: Breast Conservation in Patients with Large, Multifocal, and Multicentric Breast Cancer

Savioli¹,

Seth²,

Morrow³

et al. 2021

BCTT

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Introduction: Extreme Oncoplastic Breast Conservation Surgery (EOBCS) is offered in selected patients with multifocal or multicentric breast cancer (MFMC). Recent evidence has suggested that EOBCS may be a valuable resource for patients with MFMC who may avoid the risk associated with mastectomy in favour of the benefits of breast conservation without risking their oncological outcomes. Our study examined the practice of EOBCS in two regional breast units in Glasgow, United Kingdom. Materials and Methods: A prospectively collected database of 50 patients treated with EOBC in two breast units in Glasgow between 2007 and 2018 were evaluated, and clinical outcomes were observed. Results: Fifty patients (median age 55) underwent EOBCS, of which 43 (86%) had invasive disease. Median tumour size was 55mm (50-90) and multifocal disease was identified in 22 (44%) patients. Nine patients (18%) were found to have positive margins and underwent a second procedure, with 6 (12%) proceeding to mastectomy. Five-year disease free survival rate was 91.5%, while cancer-specific survival was 95.7%. Conclusion: EOBCS is oncologically safe in short-term follow-up. Large scale studies are required to confirm these preliminary results, in order to offer EOBCS as a valid option to patients with advanced or multifocal breast cancer.

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Multifocal and multicentric breast cancer, is it time to think again?

Cited by 30 publications

References 32 publications

A prospective cohort study of the safety of breast cancer surgery during COVID-19 pandemic in the West of Scotland

A prospective cohort study of the safety of breast cancer surgery during COVID-19 pandemic in the West of Scotland

What is the effect of advanced diagnostic methods on sensitivity and survival in the multiple breast cancers? A systematic analysis and comparison

Extreme Oncoplasty: Breast Conservation in Patients with Large, Multifocal, and Multicentric Breast Cancer

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