Multifidus Muscles Lipid Content Is Associated with Intervertebral Disc Degeneration: A Quantitative Magnetic Resonance Imaging Study

Ogon, Izaya; Takebayashi, Toru; Takashima, Hiroyuki; Morita, Tomohiro; Oshigiri, Tsutomu; Terashima, Yoshiaki; Yoshimoto, Mitsunori; Yamashita, Toshihiko

doi:10.31616/asj.2018.0258

Cited by 11 publications

(16 citation statements)

References 28 publications

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“…Studies have demonstrated that IMCL are significantly higher in those with chronic LBP and that there is a positive correlation between IMCL and VAS 78–80 . IMCL are also significantly correlated with sagittal alignment and anterior annulus fibrosus degeneration 76,77 . In contrast, EMCL have not been found to be significantly different between chronic LBP and normal groups 76 .…”

Section: Literature Reviewmentioning

confidence: 99%

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Imaging Evaluation of Fat Infiltration in Paraspinal Muscles on MRI: A Systematic Review with a Focus on Methodology

Han

Jiang

Zhang

et al. 2021

Orthopaedic Surgery

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Purpose: Numerous studies have applied a variety of methods to assess paraspinal muscle degeneration. However, the methodological differences in imaging evaluation may lead to imprecise or inconsistent results. This article aimed to provide a pragmatic summary review of the current imaging modalities, measurement protocols, and imaging parameters in the evaluation of paraspinal muscle fat infiltration (FI) in MRI studies.Methods: Web of Science, EMBASE, and PubMed were searched from January 2005 to March 2020 to identify studies that examined the FI of paraspinal muscles on MRI among patients with lumbar degenerative diseases.Results: Intramyocellular lipids measured by magnetic resonance spectroscopy and FI measured by chemical-shift MRI were both correlated to low back pain and several degenerative lumbar diseases, whereas results on the relationship between FI and degenerative lumbar pathologies using conventional MRI were conflicting. Multi-segment measurement of FI at the lesion segment and adjacent segments could be a prognostic indicator for lumbar surgery. Most studies adopted the center of the intervertebral disc or endplate as the level of slice to evaluate the FI. Compared with visual semiquantitative assessment, quantitative parameters appeared to be precise for eliminating individual or modality differences. It has been demonstrated that fat CSA/total CSA (based on area) and muscle-fat index (based on signal intensity) as quantitative FI parameters are associated with multiple lumbar diseases and clinical outcomes after surgery. Conclusion:Having a good command of the methodology of paraspinal muscle FI on MRI was effective for diagnosis and prognosis in clinical practice.

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Section: Literature Reviewmentioning

confidence: 99%

“…Because of the relatively limited accuracy of conventional MRI, several novel MRI modalities have emerged. We found some studies that applied MRS 7,[75][76][77][78][79][80][81] , chemical-shift MRI 51,69,[82][83][84][85] and multi-echo MRI 75 . A comparison of different MRI modalities is included in Table 1.…”

Section: Novel Mri Modalitiesmentioning

confidence: 99%

Imaging Evaluation of Fat Infiltration in Paraspinal Muscles on MRI: A Systematic Review with a Focus on Methodology

Han

Jiang

Zhang

et al. 2021

Orthopaedic Surgery

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“…This study followed a previously described MRI protocol [20][21][22][23][24]. Briefly, T2-weighted sagittal and transverse magnetic resonance (MR) images were obtained using the Signa HDx 1.5 T MRI system (GE Healthcare, Milwaukee, WI, USA) with a spine coil.…”

Section: Magnetic Resonance Imaging Protocolmentioning

confidence: 99%

“…MRS data were analyzed according to a previously described method [20][21][22][23][24]. Spectral data were used to measure EMCL and IMCL contents using the LCModel software (Stephen Provencher Inc., Oakville, ON, Canada).…”

Section: Analysis Of Magnetic Resonance Spectroscopy Datamentioning

confidence: 99%

Is the Lipid Content of the Psoas Major Correlated with Chronic Low Back Pain and Spinopelvic Alignment? A Magnetic Resonance Spectroscopic Study

et al. 2020

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Study Design: Cross-sectional observational study.Purpose: This study aimed to analyze any potential associations of extramyocellular lipid (EMCL) and intramyocellular lipid (IMCL) contents with (1) the intensity of low back pain (LBP); (2) age, cross-sectional area (CSA), and fatty infiltration (FI) of the psoas major; and (3) spinopelvic parameters.Overview of Literature: The psoas major has clinically relevant function; however, the association of this muscle with chronic LBP is controversial. Magnetic resonance spectroscopy enables a detailed analysis of the composition of muscular fat tissues such as its EMCL and IMCL contents.Methods: The study population comprised 40 patients (19 males, 21 females; mean age, 61.7±2.4 years). Possible correlations of LBP Visual Analog Scale (VAS) scores, age, CSA, FI, and spinopelvic parameters with EMCL and IMCL contents of the psoas major were assessed.Results: No association was identified between the EMCL and IMCL contents and LBP VAS scores (r=0.05, p=0.79 and r=0.06, p=0.75, respectively). The EMCL content correlated with age (r=0.47, p<0.01), body mass index (BMI) (r=0.44, p<0.01), CSA (r=−0.59, p< 0.01), and FI (r=0.49, p<0.01). EMCL content showed a significant negative correlation with sacral slope (SS) (r=−0.43, p<0.05) and positive correlation with pelvic tilt (PT) (r=0.56, p<0.01).Conclusions: EMCL content correlated with age, BMI, CSA, and FI of the psoas major, while IMCL content had no correlation. This study found correlations between SS and PT and EMCL content of the psoas major, but no correlations were found between spinopelvic parameters and IMCL content of the psoas major.

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“…Our results indicated that the IMCL of the Mm might be accompanied with posterior AF degeneration. The Mm as well as anterior AF of IVD were important for the function of the lumbar spinal column, and had cross‐correlation each other …”

Section: Ivd and Advances In Diagnostic Imagingmentioning

confidence: 99%

Imaging diagnosis for intervertebral disc

Ogon

Takebayashi²,

Takashima

et al. 2019

JOR Spine

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Various functional magnetic resonance imaging (MRI) techniques have been investigated in recent years and are being used in clinical practice for the patients with low back pain (LBP). MRI is an important modality for diagnosing intervertebral disc (IVD) degeneration. In recent years, there have been several reported attempts to use MRI T2 mapping and MRI T1ρ mapping to quantify lumbar disc degeneration. MRI T2 mapping involves digitizing water content, proteoglycan content, and collagen sequence breakdown as relaxation times (T2 values) at each site. These digitized values are used to create a map, that is, then used to quantitatively evaluate the metabolite concentrations within IVD tissues. MRI T2 mapping utilizes the T2 relaxation time to quantify moisture content and the collagen sequence breakdown. MRI T1ρ mapping digitizes water molecule dispersion within the cartilaginous matrix to evaluate the degree of cartilaginous degeneration. Magnetic resonance spectroscopy is a less‐invasive diagnostic test that provides biochemical information. Adequate analysis of the IVD has not yet been performed, although there are indications of a relationship between the adipose content of the multifidus muscle in the low back and LBP. The ultra short TE technique has been recently used to investigate lumbar cartilaginous endplates. Unlike diagnosis based on contrast‐enhanced images of the IVD, which depends on the recurrence of pain that is determined subjectively, MRI‐based diagnosis is less‐invasive and based on objective imaging findings. It is therefore expected to play a key role in the diagnostic imaging of IVD conditions in the future.

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Multifidus Muscles Lipid Content Is Associated with Intervertebral Disc Degeneration: A Quantitative Magnetic Resonance Imaging Study

Cited by 11 publications

References 28 publications

Imaging Evaluation of Fat Infiltration in Paraspinal Muscles on MRI: A Systematic Review with a Focus on Methodology

Imaging Evaluation of Fat Infiltration in Paraspinal Muscles on MRI: A Systematic Review with a Focus on Methodology

Is the Lipid Content of the Psoas Major Correlated with Chronic Low Back Pain and Spinopelvic Alignment? A Magnetic Resonance Spectroscopic Study

Imaging diagnosis for intervertebral disc

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