Multidrug-Resistant Nontuberculous Mycobacteria Isolated from Cystic Fibrosis Patients

Cândido, Pedro Henrique Campanini; Nunes, Luciana Neves; Marques, Elizabeth Andrade; Folescu, Tânia Wrobel; Coelho, Fábrice Santana; Moura, Vinicius Calado Nogueira de; Silva, Marlei Gomes da; Gomes, Karen Machado; Lourenço, Maria Cristina da Silva; Aguiar, Fábio Silva; Chitolina, Fernanda; Armstrong, Derek T; Leão, Sylvia Cardoso; Neves, Felipe Piedade Gonçalves; Mello, Fernanda Carvalho de Queiroz; Duarte, Rafael Silva

doi:10.1128/jcm.00549-14

Cited by 45 publications

(34 citation statements)

References 32 publications

(45 reference statements)

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“…abscessus, with M. abscessus subsp. massiliense forming a minority of isolates, as seen in most other reports (Tables 1 and 2) [3,13,[28][29][30][31] from countries other than Brazil [32]. No M. abscessus subsp.…”

Section: Resultsmentioning

confidence: 79%

Molecular epidemiology of Mycobacterium abscessus complex isolates in Ireland

O'Driscoll

Konjek

Heym

et al. 2016

Journal of Cystic Fibrosis

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Section: Resultsmentioning

confidence: 79%

Molecular epidemiology of Mycobacterium abscessus complex isolates in Ireland

O'Driscoll

Konjek

Heym

et al. 2016

Journal of Cystic Fibrosis

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“…Another case of pulmonary disease with multiple isolations of M. marseillense has been reported for a patient with lupus erythematosus (120). Two strains have been isolated from respiratory specimens of cystic fibrosis patients (121).…”

Section: Mycobacterium Marseillensementioning

confidence: 99%

“…Very recently, two isolations were reported in Latin America: one, in Brazil, from a pulmonary specimen from a cystic fibrosis patient (121), and the other, in Ecuador, from an HIV patient (156).…”

Section: Mycobacterium Timonensementioning

confidence: 99%

Microbiological Features and Clinical Relevance of New Species of the Genus Mycobacterium

2014

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SUMMARY Nontuberculous mycobacteria (NTM) are present in the environment, mainly in water, and are occasionally responsible for opportunistic infections in humans. Despite the fact that NTM are characterized by a moderate pathogenicity, the diseases caused by NTM at various body sites are increasing on a worldwide level. Among over 150 officially recognized NTM species, only two or three dozen are familiar to clinicians, and even to most microbiologists. In this paper, approximately 50 new species described in the last 8 years are reviewed, and their role in human infections is assessed on the basis of reported clinical cases. The small number of reports concerning most of the “new” mycobacterial species is responsible for the widespread conviction that they are very rare. Their role is actually largely underestimated, mainly because they often remain unrecognized and misidentified. Aiming to minimize such bias, emphasis has been placed on more common identification pitfalls. Together with new NTM, new members of the Mycobacterium tuberculosis complex described in the last few years are also an object of the present review.

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“…Among NTM species, an increasing number of strains have been deemed responsible, in the last decades, of severe and treatment-resistant diseases910111213. NTMs are present in the environment, in particular in water and soil14, and can occasionally infect humans or animals causing a range of pathological conditions including pulmonary, skin, bone, joint, and disseminated diseases in the presence of various predisposing conditions (primarily chronic diseases and immunosuppression)15161718.…”

mentioning

confidence: 99%

Genomic characterization of Nontuberculous Mycobacteria

Fedrizzi

Meehan

Grottola

et al. 2017

Sci Rep

166

174

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Mycobacterium tuberculosis and Mycobacterium leprae have remained, for many years, the primary species of the genus Mycobacterium of clinical and microbiological interest. The other members of the genus, referred to as nontuberculous mycobacteria (NTM), have long been underinvestigated. In the last decades, however, the number of reports linking various NTM species with human diseases has steadily increased and treatment difficulties have emerged. Despite the availability of whole genome sequencing technologies, limited effort has been devoted to the genetic characterization of NTM species. As a consequence, the taxonomic and phylogenetic structure of the genus remains unsettled and genomic information is lacking to support the identification of these organisms in a clinical setting. In this work, we widen the knowledge of NTMs by reconstructing and analyzing the genomes of 41 previously uncharacterized NTM species. We provide the first comprehensive characterization of the genomic diversity of NTMs and open new venues for the clinical identification of opportunistic pathogens from this genus.

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Multidrug-Resistant Nontuberculous Mycobacteria Isolated from Cystic Fibrosis Patients

Cited by 45 publications

References 32 publications

Molecular epidemiology of Mycobacterium abscessus complex isolates in Ireland

Molecular epidemiology of Mycobacterium abscessus complex isolates in Ireland

Microbiological Features and Clinical Relevance of New Species of the Genus Mycobacterium

Genomic characterization of Nontuberculous Mycobacteria

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