Multicomponent Synthesis of 3,4-Dihydropyrimidin-2-(1H)-Ones with a Cu/Silica Xerogel Composite Catalyst

Recoverable Cu/SiO2 composite-catalysed click synthesis of 1,2,3-triazoles in water media

“…Previous studies showed that a Cu/SiO 2 composite, synthesized by the sol-gel method, was successfully employed to promote the multicomponent dihydropyrimidinone synthesis known as Biginelli's reaction. 52 More recently, a series of dihydropyridines were easily prepared in one step synthesis through catalysis by an analogous In/SiO 2 composite. 53 In this report, we wish to disclose our results towards the development of a new eco-friendly multicomponent approach, in which 1,2,3-triazoles were synthesized in high yields and with high regioselectivities promoted by the heterogeneous Cu/SiO 2 composite catalyst.…”

Preliminary studies on Cu/SiO2 catalyzed imidazo[1,2-a]pyridine multicomponent synthesis

“…3 This composite was characterized by SEM-EDS and present superficial data of copper quantity as 0,9 mmol.g -1 . BET isotherms indicated a microporous material.…”

Crystal structure of ethyl 4-(2-methoxyphenyl)-6-methyl-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate

“…For syntheses of dihydropyrimidinones and their analogous, see: Biginelli (1893); Varala et al (2003); Gohain et al (2004); Ahmed et al (2009). For biological activities of hydropyrimidinones, see: Salehi et al (2006); Singh et al (2010); Hed et al (2009); Russowsky et al (2007); Shah et al (2009). For the synthesis of the title compound, see: Ahmed et al (2012 Table 1 Hydrogen-bond geometry (Å , ).…”

“…Dihydropyrimidin-2(1H)-one scaffold compounds are an important class of substances in organic and medicinal chemistry. Aryl-substituted 3, 4-dihydropyrimidin-2(1H)-ones and their sulfur analogue have been reported to possess diverse range of pharmacological activity (Salehi et al, 2006) such as anticancer, anti HIV, antibacterial, antimalarial, antihypertensive, sedative, hypnotics, anticonvulsant, antithyroid,antihistaminic agents and antibiotics (Singh et al, 2010;Hed et al, 2009;Russowsky et al, 2007;Shah et al, 2009). This stimulated the invention of a wide range of synthetic methods for their preparation and chemical transformations.…”