Multicomponent domino reactions for the synthesis of biologically active natural products and drugs

Serendipitous Conversion of an Acetylamino Dideoxy-Octonic Acid Derivate into a Functionalized Carbohydrate–Pyrazole Conjugate and Investigation of the Method´s General Applicability

“…The above findings support the assumption that the formation of pyrazole ( 11) from ADOA-PAE (7) by nitrosation followed a five-step domino reaction [34,35]. Studies to investigate the features of this remarkable transformation led to two novel protocols for the synthesis of pyrazoles.…”

Serendipitous Conversion of an Acetylamino Dideoxy-Octonic Acid Derivate into a Functionalized Carbohydrate–Pyrazole Conjugate and Investigation of the Method´s General Applicability

“…The above findings support the assumption that the formation of pyrazole ( 11) from ADOA-PAE (7) by nitrosation followed a five-step domino reaction [34,35]. Studies to investigate the features of this remarkable transformation led to two novel protocols for the synthesis of pyrazoles.…”

Antiproliferative Effects of Matricine in Gemcitabine-Resistant Human Pancreatic Carcinoma Cells Are Mediated via Mitochondrial-Mediated Apoptosis, Inhibition of Cell Migration, Invasion Suppression, and Mammalian Target of Rapamycin (mTOR)-TOR/PI3K/AKT Signalling Pathway

“…Moreover, the emergence of drug resistance in pancreatic cancer cells makes it very difficult to treat pancreatic cancer with existing drugs [10]. Plants are a diverse repository of chemical entities that may prove to be essential in the development of safer chemotherapy for the treatment of pancreatic cancer [2,3]. In the present study we assessed the anticancer effects of matricine, a plant-derived sesquiterpene, against capan-2 pancreatic cancer cells and normal pancreatic HTRET-HPNE cells.…”

A Smart (Ar‐tpy)Cu I NO 2 Nanocatalyst for Dual C–N Coupled Reductive Cyclization of Phthaladehyde With Imidates to Furnish Isoindolin‐1‐Ones

“…create a unique electronic atmosphere in the field of organic synthesis and perform both as electrophile and nucleophile for homo-and heteroatomic coupling reactions to achieve diverse and valuable compounds [42][43][44][45][46][47][48][49][50][51][52]. Nitrogen-based heterocyclic frameworks are one of the most abundant and key structural motifs present in pharmaceuticals and material chemistry applications as a consequence of their pervasive occurrence in several natural products and biologically active precursors [ 44,[53][54][55][56][57][58]. Functionalized N -substituted isoindolin-1-one cores gained significant attention from synthetic chemists in recent years due to their vast applications in biological and potential therapeutic activities [59][60][61][62][63].…”

Serendipitous Conversion of an Acetylamino Dideoxy-Octonic Acid Derivate into a Functionalized Carbohydrate–Pyrazole Conjugate and Investigation of the Method´s General Applicability

“…The above findings support the assumption that the formation of pyrazole ( 11) from ADOA-PAE (7) by nitrosation followed a five-step domino reaction [34,35]. Studies to investigate the features of this remarkable transformation led to two novel protocols for the synthesis of pyrazoles.…”

Antiproliferative Effects of Matricine in Gemcitabine-Resistant Human Pancreatic Carcinoma Cells Are Mediated via Mitochondrial-Mediated Apoptosis, Inhibition of Cell Migration, Invasion Suppression, and Mammalian Target of Rapamycin (mTOR)-TOR/PI3K/AKT Signalling Pathway

“…Moreover, the emergence of drug resistance in pancreatic cancer cells makes it very difficult to treat pancreatic cancer with existing drugs [10]. Plants are a diverse repository of chemical entities that may prove to be essential in the development of safer chemotherapy for the treatment of pancreatic cancer [2,3]. In the present study we assessed the anticancer effects of matricine, a plant-derived sesquiterpene, against capan-2 pancreatic cancer cells and normal pancreatic HTRET-HPNE cells.…”

A Smart (Ar‐tpy)Cu I NO 2 Nanocatalyst for Dual C–N Coupled Reductive Cyclization of Phthaladehyde With Imidates to Furnish Isoindolin‐1‐Ones

“…create a unique electronic atmosphere in the field of organic synthesis and perform both as electrophile and nucleophile for homo-and heteroatomic coupling reactions to achieve diverse and valuable compounds [42][43][44][45][46][47][48][49][50][51][52]. Nitrogen-based heterocyclic frameworks are one of the most abundant and key structural motifs present in pharmaceuticals and material chemistry applications as a consequence of their pervasive occurrence in several natural products and biologically active precursors [ 44,[53][54][55][56][57][58]. Functionalized N -substituted isoindolin-1-one cores gained significant attention from synthetic chemists in recent years due to their vast applications in biological and potential therapeutic activities [59][60][61][62][63].…”

Serendipitous Conversion of an Acetylamino Dideoxy-Octonic Acid Derivate into a Functionalized Carbohydrate–Pyrazole Conjugate and Investigation of the Method´s General Applicability

“…The above findings support the assumption that the formation of pyrazole ( 11) from ADOA-PAE (7) by nitrosation followed a five-step domino reaction [34,35]. Studies to investigate the features of this remarkable transformation led to two novel protocols for the synthesis of pyrazoles.…”

Antiproliferative Effects of Matricine in Gemcitabine-Resistant Human Pancreatic Carcinoma Cells Are Mediated via Mitochondrial-Mediated Apoptosis, Inhibition of Cell Migration, Invasion Suppression, and Mammalian Target of Rapamycin (mTOR)-TOR/PI3K/AKT Signalling Pathway

“…Moreover, the emergence of drug resistance in pancreatic cancer cells makes it very difficult to treat pancreatic cancer with existing drugs [10]. Plants are a diverse repository of chemical entities that may prove to be essential in the development of safer chemotherapy for the treatment of pancreatic cancer [2,3]. In the present study we assessed the anticancer effects of matricine, a plant-derived sesquiterpene, against capan-2 pancreatic cancer cells and normal pancreatic HTRET-HPNE cells.…”

A Smart (Ar‐tpy)Cu I NO 2 Nanocatalyst for Dual C–N Coupled Reductive Cyclization of Phthaladehyde With Imidates to Furnish Isoindolin‐1‐Ones

“…create a unique electronic atmosphere in the field of organic synthesis and perform both as electrophile and nucleophile for homo-and heteroatomic coupling reactions to achieve diverse and valuable compounds [42][43][44][45][46][47][48][49][50][51][52]. Nitrogen-based heterocyclic frameworks are one of the most abundant and key structural motifs present in pharmaceuticals and material chemistry applications as a consequence of their pervasive occurrence in several natural products and biologically active precursors [ 44,[53][54][55][56][57][58]. Functionalized N -substituted isoindolin-1-one cores gained significant attention from synthetic chemists in recent years due to their vast applications in biological and potential therapeutic activities [59][60][61][62][63].…”