Multicenter visual outcomes comparison of 2 trifocal presbyopia-correcting IOLs: 6-month postoperative results

Abstract

Purpose: To clinically evaluate visual performance of the AcrySof IQ PanOptix TFNT00 and AT LISA tri 839MP intraocular lenses (IOLs) in binocular visual acuity (VA) and to characterize low-contrast visual performance at 6 months postimplantation. Setting: Multicenter, 15 sites. Design: Prospective, parallel-group, randomized, double-masked, postmarketing clinical study. Methods: Binocular uncorrected distance (UDVA, 4 m), intermediate (UIVA, 60 cm), and near (UNVA, 40 cm) visual acuities and binocular defocus curves were evaluated under photopic lighting conditions. Photopic and mesopic contrast sensitivities with and without glare were assessed. Results: The study included 182 subjects (62% women; mean age, 66 ± 9.4 years) who were implanted bilaterally with the TFNT00 IOL (n = 93) or 839MP IOL (n = 89), and binocular VA was evaluated 4 to 6 months (120–180 days) postimplantation. The TFNT00 IOL group showed superior visual outcomes compared with the 839MP IOL group in binocular UIVA (P = .001) and UNVA (P = .003) and noninferior outcomes in UDVA (95% CI, −0.023 to 0.041; upper limit <0.1 logarithm of the minimum angle of resolution [logMAR] [margin of noninferiority]). Mean defocus curve from 0.00 to −3.00 diopter (D) ranged from 0.1 to 0.0 logMAR for both IOLs; better mean VA values (logMAR) were observed in the TFNT00 IOL group between −1.50 and −2.50 D compared with those of the 839MP IOL group. Contrast sensitivity values were similar between the 2 groups in all conditions. Conclusions: The results of this study showed improved visual performance at near and intermediate distances with the TFNT00 IOL compared with that of the 839MP IOL.

AcrySof IQ PanOptix Intraocular Lens Versus Extended Depth of Focus Intraocular Lens and Trifocal Intraocular Lens: A Clinical Overview

“…10,18,21–23,25 PanOptix performed significantly better for near vision compared with Symfony, FineVision, and AT LISA. 16,23,27 Symfony demonstrated a better intermediate performance than trifocals, and AT LISA and Fine Vision showed better performance at distance and near vision than the EDOF IOL. 67…”

“…20 In addition, results of a PanOptix study that were presented at the ESCRS 2018 conference are also briefly discussed (not part of the literature search). 27…”

“…One randomized, double-masked, prospective and multicenter study compared the performance of PanOptix (n = 93) with the AT LISA IOL (n = 89). 27 The PanOptix group achieved significantly better binocular UIVA at 60 cm ( P < 0.002) and binocular UNVA at 40 cm ( P < 0.003) versus AT LISA. On the defocus curve, the PanOptix group achieved a mean VA of 20/25 or better from +0.50 D to −2.50 D and higher (ie, better) mean VA between −1.50 D and −2.50 D versus AT LISA.…”

“…22,24 In majority of PanOptix patients photic disturbances had no impact on their daily life and these were reported to decrease with time. 17,27 This phenomenon has been termed as neuroadaptation, wherein patients require a certain postoperative period to adjust to the retinal images, and this is frequently observed with MIOLs. 73 Overall, high patient satisfaction along with complete spectacle independence for all distances (>85% across studies) has been reported with PanOptix.…”

“…Mild halos and glare were reported by a few patients in both groups within 1 to 2 weeks of implantation; these resolved without intervention. 27…”