Multicenter US Clinical Trial With an Electric-Acoustic Stimulation (EAS) System in Adults: Final Outcomes

Pillsbury, Harold C.; Dillon, Margaret T.; Buchman, Craig A.; Staecker, Hinrich; Prentiss, Sandra; Ruckenstein, Michael J.; Bigelow, Douglas C.; Telischi, Fred F.; Martinez, Diane; Runge-Samuelson, Christina L.; Friedland, David R.; Blevins, Nikolas H.; Larky, Jannine; Alexiades, George; Kaylie, David M.; Roland, Peter S.; Miyamoto, Richard T.; Backous, Douglas D.; Warren, Frank M.; El-Kashlan, Hussam K.; Slager, Heidi K.; Reyes, Carisa; Racey, Allison I.; Adunka, Oliver F.

doi:10.1097/mao.0000000000001691

Cited by 83 publications

(84 citation statements)

References 22 publications

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“…81 Similarly, Pillsbury et al demonstrated hearing preservation using the MED-EL EAS system, reporting that 79% of patients experienced less than 30 dB change in low-frequency hearing, but they reported a much higher continued use of the EAS system at 97% of patients at 1 year follow-up. 82 These findings were in line with previous studies of a similar EAS system in a smaller number of subjects. 83 However, other multicenter studies have shown a less robust preservation rate with hearing preservation electrode arrays, with 66% of patients demonstrating functional low-frequency hearing preservation at 6 months and 54% in another.…”

Section: Hearing Preservation In Cochlear Implantation: Surgical Techsupporting

confidence: 92%

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Electric and Acoustic Stimulation in Cochlear Implant Recipients with Hearing Preservation

2018

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Hearing loss affects 30 million people in the United States, and a subset of these patients have normal low-frequency hearing and ski-sloped high-frequency hearing loss. For these patients, hearing aids alone may not provide adequate benefit. Cochlear implantation alone has been utilized to improve speech perception. The addition of high-frequency electric hearing to low-frequency acoustic hearing in these patients is beneficial. Technical improvements have allowed preservation of low-frequency hearing in cochlear implant recipients, allowing for electric and acoustic stimulation in the same ear with significant improvements in speech perception, sound localization, music appreciation, and quality of life.

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Section: Hearing Preservation In Cochlear Implantation: Surgical Techsupporting

confidence: 92%

“…Additionally, some studies exclude patients shown to have poor long-term outcomes, such as those with older than 65 years and with greater than 30 years of prior deafness and this also should be taken into consideration with the reported hearing preservation rates. 82…”

Section: Hearing Preservation In Cochlear Implantation: Surgical Techmentioning

confidence: 99%

Electric and Acoustic Stimulation in Cochlear Implant Recipients with Hearing Preservation

2018

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“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14] In 2014, the Nucleus Hybrid L24 cochlear implant (CI) 15 and in 2016, the MED-EL FLEX 20 and 24 CIs 16 were approved by the Food and Drug Administration (FDA) for implantation in those with these indications. In both clinical trials (CTs) 15,16 and in other subsequent research studies, 1,7,10,[13][14][15]17 outcomes demonstrate that by preserving the LF hearing, listeners can utilize fine-timing information 11,18 to aid speech perception in noise and music, 9,11 and maintain localization abilities. [19][20][21][22] Subsequently, the electrically encoded high-frequency information provides important spectral information.…”

Section: Introductionmentioning

confidence: 99%

Nucleus Hybrid S12: Multicenter Clinical Trial Results

et al. 2020

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Objectives/Hypothesis The use of a short 10‐mm/10‐electrode cochlear implant to preserve low‐frequency residual hearing was investigated. This report describes the 12‐month outcomes of this multicenter clinical trial. Study Design Single‐subject design. Methods Twenty‐eight subjects with low‐frequency hearing at or better than 60 dB HL at 500 Hz and severe high‐frequency hearing loss were implanted with a Nucleus Hybrid S12 implant in their poorer ear. Speech perception in quiet using Consonant‐Nucleus‐Consonant (CNC) words and sentences in noise using AzBio sentences was collected pre‐ and postoperatively at 3, 6, and 12 months. Subjective reporting using the Speech, Spatial, and Qualities of Hearing Scale (SSQ) questionnaire was also collected pre‐ and postoperatively. Results Functional hearing preservation was accomplished in 96% of subjects. At 3 and 6 months, 86% of the 28 subjects had maintained functional hearing. By 12 months, 23 out of 27 subjects (85%) had maintained functional hearing (one subject with functional hearing at 6 months withdrew from the study prior to the 12‐month visit). Speech perception results demonstrated that 81% of the participants on CNC words and 77% with AzBio sentences in noise had significant improvements using their everyday listening condition at 12 months compared to preoperative performance with bilateral hearing aids. Furthermore, preoperative to 12 months postoperative subjective ratings showed significant improvements for the SSQ. Conclusions This study demonstrates that a high degree of hearing preservation enabling acoustic‐electric hearing and improvement in speech understanding in quiet and in noise can be accomplished using a short‐electrode 10‐mm cochlear implant. Level of Evidence 2c Laryngoscope, 130:E548–E558, 2020

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“…A CI532-es (narancsszínű, tömör átmetszetű) elektródaprofil körülbelül 60%-os relatív keresztmetszet-csökkenése, következményes intracochlearispozíció-változása szembetűnő a korábbi, CI512-es (narancsszínű, szaggatott körvonalú) elektródaprofilhoz képest ESETISMERTETÉS EAS-t alkalmazva a magashang-tartományban károsodott szőrsejtek területét, azaz a basalis régiót sok esetben egy rövid elektródasor bevezetésével fedik le, mellyel megkímélhető az apicalis cochlearis régiók szerkezete, működése. Ez esetben a kihívást a residualis hallás hoszszabb távú megőrzése jelenti [19]. Ha ugyanis a mélyhang-hallásban progresszió következik be, az eredetileg optimális hosszúságú elektróda, fizikai lefedettség hiányában, már nem lesz képes pótolni a cochlea ezen régiójának funkcióját.…”

Section: áBraunclassified

A maradványhallás megőrzésének lehetőségei cochlearis implantáció során Nucleus CI532 Slim Modiolar elektródasorral

et al. 2018

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During the rehabilitation of hearing-impaired patients, the preservation of residual acoustic hearing following cochlear implantation by minimizing the implantation trauma allows for improved hearing performance. To achieve this, minimally invasive, soft surgery methods and thinner, atraumatic electrodes were required. In our present study, we reported a case where Cochlear® Nucleus CI532 Slim Modiolar electrode was implanted in a patient with residual hearing. Our aim was to study the possible preservation of postoperative acoustic residual hearing by audiological monitoring. Since childhood, due to her congenital hearing loss, she has been wearing a conventional, airborne hearing correction device on both ears. Six months before cochlear implantation, we measured the progression on both sides of the hearing loss, so we decided to perform cochlear implantation. The patient had residual hearing on both ears prior to surgery thus the Cochlear® Nucleus CI532 Slim Modiolar Implant was used. The minimally invasive surgery was performed on the patient’s right ear through the round window approach. Compared to the preoperative hearing threshold (average 85 dBHL) in the 4th postoperative week, an initial hearing threshold progression of 20–25 dBHL was observed between 0.25 and 1.0 kHz, while of 5–10 dBHL between 2.0–4.0 kHz. Hearing threshold measured in the 6th month showed a slight progression in the range above 1 kHz, but improved by the 12th month, to the results achieved at the 4th week. The effects of cochlear implantation on residual hearing have been studied in numerous studies, in which several key surgical and technical factors have been identified. Nucleus CI532 is a Slim Modiolar electrode profile that is close to the modiolus, so it is expected to have a lower endocochlear hydrodynamic load since it lies in the covering of the osseus spiral lamina, thus less influencing the dynamics of the basilar membrane. However, the perimodiolar location of the electrode array allows the adjacent nerve elements of the spiral ganglion to be stimulated with a lower electrical intensity and a reduced surface that may be neuroprotective. Preservation of acoustic residual hearing following cochlear implantation improves the patient’s speech perception and the sound localization skills, particularly in difficult circumstances. Long-term residual hearing preservation may also be of great importance in the subsequent feasibility for regenerative procedures and drug treatments. Orv Hetil. 2018; 159(41): 1680–1688.

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Multicenter US Clinical Trial With an Electric-Acoustic Stimulation (EAS) System in Adults: Final Outcomes

Cited by 83 publications

References 22 publications

Electric and Acoustic Stimulation in Cochlear Implant Recipients with Hearing Preservation

Electric and Acoustic Stimulation in Cochlear Implant Recipients with Hearing Preservation

Nucleus Hybrid S12: Multicenter Clinical Trial Results

A maradványhallás megőrzésének lehetőségei cochlearis implantáció során Nucleus CI532 Slim Modiolar elektródasorral

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