Multiaxial strength characteristics of trabecular bone

Stone, John L.; Beaupré, Gary S.; Hayes, Wilson C.

doi:10.1016/0021-9290(83)90083-0

Cited by 118 publications

(45 citation statements)

References 18 publications

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“…It is also interesting to note that measured "ISS" for the implants was considerably reduced compared to the UCS of the implants at the same time point. These results, coupled with the similarity between the reported value of 6 MPa for the shear strength of cancellous bone 54 and the ultimate magnitude of ISS measured during this study indicate that the push-out tests were measuring the shear strengths of the bone/ implant composites, not the bone implant interfaces, and that the mechanical integrity of the implant/bone composite in shear had been maintained from 13 to 26 weeks, at a constant value of ϳ7 MPa, irrespective of the implant porosity or ingrowth morphology.…”

Section: Implant Fixationsupporting

confidence: 87%

Mediation of bone ingrowth in porous hydroxyapatite bone graft substitutes

Hing

Best

Tanner

et al. 2003

J Biomedical Materials Res

191

137

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Abstract:Previous investigations have shown that both the early biological response and the mechanical properties of a porous hydroxyapatite bone graft substitute are highly sensitive to its pore structure. The objective of this study was to evaluate whether the pore structure continued to influence bone integration in the medium to long term. Two screened batches of porous hydroxyapatite (PHA) designated as batch A and batch B, with porosities of ϳ60 and 80%, respectively, were selected for this study and implanted for periods of 5, 13, and 26 weeks into the lower femur of New Zealand White rabbits. Histomorphometric analysis of the absolute volume of bone ingrowth within batch A and B implants from 5 to 26 weeks showed that the absolute volume of bone ingrowth was consistently lower in batch A (10 -21%), compared to batch B implants (24 -31%). However, when the volume of bone ingrowth was normalised for the available pore space, this difference was reduced (23-47% and 32-42% for batches A and B, respectively). These observations suggest that differences in the volume of bone ingrowth initially depended on pore interconnectivity rather than pore size, whereas the volume or morphology of the PHA influenced the volume and morphology of bone ingrowth at later time points. Compression testing showed that bone ingrowth had a strong reinforcing effect on PHA bone graft substitutes, and a strong correlation was identified between mechanical properties and the absolute volume of ingrowth for both batches A and B. Furthermore, at 13 and 26 weeks, there was no significant variation in the ultimate compressive strength of integrated batch A and B implants. This similarity in ultimate mechanical properties indicated that the absolute volume of ingrowth may be mediated by the PHA structure through its impact on the dynamics of the local biomechanical environment. The results of push-out testing showed that fixation of PHA bone graft substitutes was independent of density within the range studied, with no significant difference in the interfacial shear stress between batches A and B at each time point throughout the study.

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Section: Implant Fixationsupporting

confidence: 87%

Mediation of bone ingrowth in porous hydroxyapatite bone graft substitutes

Hing

Best

Tanner

et al. 2003

J Biomedical Materials Res

191

137

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“…39,[43][44][45] Similarly, the ultimate strain of the BCs (7.3% -0.6%) exceeds that of trabecular bone in human femora (1.05% -0.46%) 46 , while the toughness (1072 -292 kJ$m ( 39 )]. Under torsional deformation, the strength and modulus of the BCs are 2.9 -1.4 and 121 -18 MPa, respectively, which are close to values reported for human, 31,47 bovine, 48,49 canine, 43 and ovine 50,51 trabecular bone ranging from 3.1 to 7.7 MPa and 263 to 366 MPa, respectively. However, the ultimate strain of the BC (5.0% -1.2%) is comparable to a previous study reporting strain at failure of 4.6% -1.3% for trabecular bone.…”

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confidence: 81%

Balancing the Rates of New Bone Formation and Polymer Degradation Enhances Healing of Weight-Bearing Allograft/Polyurethane Composites in Rabbit Femoral Defects

Dumas

Prieto

Zienkiewicz

et al. 2014

Tissue Engineering Part A

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There is a compelling clinical need for bone grafts with initial bone-like mechanical properties that actively remodel for repair of weight-bearing bone defects, such as fractures of the tibial plateau and vertebrae. However, there is a paucity of studies investigating remodeling of weight-bearing bone grafts in preclinical models, and consequently there is limited understanding of the mechanisms by which these grafts remodel in vivo. In this study, we investigated the effects of the rates of new bone formation, matrix resorption, and polymer degradation on healing of settable weight-bearing polyurethane/allograft composites in a rabbit femoral condyle defect model. The grafts induced progressive healing in vivo, as evidenced by an increase in new bone formation, as well as a decrease in residual allograft and polymer from 6 to 12 weeks. However, the mismatch between the rates of autocatalytic polymer degradation and zero-order (independent of time) new bone formation resulted in incomplete healing in the interior of the composite. Augmentation of the grafts with recombinant human bone morphogenetic protein-2 not only increased the rate of new bone formation, but also altered the degradation mechanism of the polymer to approximate a zero-order process. The consequent matching of the rates of new bone formation and polymer degradation resulted in more extensive healing at later time points in all regions of the graft. These observations underscore the importance of balancing the rates of new bone formation and degradation to promote healing of settable weight-bearing bone grafts that maintain bone-like strength, while actively remodeling.

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“…8,43,44,58 However, bone is subjected in vivo to superimposed axial-torsional or multiaxial loading. 7,9,50 Nevertheless, studies focusing on axial loading only 24,57 have not provided much information on the age-related alterations in the mechanisms of bone failure and remodelling.…”

Section: Introductionmentioning

confidence: 99%

Uniaxial and Multiaxial Fatigue Life Prediction of the Trabecular Bone Based on Physiological Loading: A Comparative Study

et al. 2015

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Abstract-Fatigue assessment of the trabecular bone has been developed to give a better understanding of bone properties. While most fatigue studies are relying on uniaxial compressive load as the method of assessment, in various cases details are missing, or the uniaxial results are not very realistic. In this paper, the effect of three different load histories from physiological loading applied on the trabecular bone were studied in order to predict the first failure surface and the fatigue lifetime. The fatigue behaviour of the trabecular bone under uniaxial load was compared to that of multiaxial load using a finite element simulation. The plastic strain was found localized at the trabecular structure under multiaxial load. On average, applying multiaxial loads reduced more than five times the fatigue life of the trabecular bone. The results provide evidence that multiaxial loading is dominated in the low cycle fatigue in contrast to the uniaxial one. Both bone volume fraction and structural model index were best predictors of failure (p < 0.05) in fatigue for both types of loading, whilst uniaxial loading has indicated better values in most cases.

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Multiaxial strength characteristics of trabecular bone

Cited by 118 publications

References 18 publications

Mediation of bone ingrowth in porous hydroxyapatite bone graft substitutes

Mediation of bone ingrowth in porous hydroxyapatite bone graft substitutes

Balancing the Rates of New Bone Formation and Polymer Degradation Enhances Healing of Weight-Bearing Allograft/Polyurethane Composites in Rabbit Femoral Defects

Uniaxial and Multiaxial Fatigue Life Prediction of the Trabecular Bone Based on Physiological Loading: A Comparative Study

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