Multi Texture Analysis of Colorectal Cancer Continuum Using Multispectral Imagery

Abstract

PurposeThis paper proposes to characterize the continuum of colorectal cancer (CRC) using multiple texture features extracted from multispectral optical microscopy images. Three types of pathological tissues (PT) are considered: benign hyperplasia, intraepithelial neoplasia and carcinoma.Materials and MethodsIn the proposed approach, the region of interest containing PT is first extracted from multispectral images using active contour segmentation. This region is then encoded using texture features based on the Laplacian-of-Gaussian (LoG) filter, discrete wavelets (DW) and gray level co-occurrence matrices (GLCM). To assess the significance of textural differences between PT types, a statistical analysis based on the Kruskal-Wallis test is performed. The usefulness of texture features is then evaluated quantitatively in terms of their ability to predict PT types using various classifier models.ResultsPreliminary results show significant texture differences between PT types, for all texture features (p-value < 0.01). Individually, GLCM texture features outperform LoG and DW features in terms of PT type prediction. However, a higher performance can be achieved by combining all texture features, resulting in a mean classification accuracy of 98.92%, sensitivity of 98.12%, and specificity of 99.67%.ConclusionsThese results demonstrate the efficiency and effectiveness of combining multiple texture features for characterizing the continuum of CRC and discriminating between pathological tissues in multispectral images.

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MRI features predict p53 status in lower-grade gliomas via a machine-learning approach

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Assessment of severity in neuropsychiatric disorders based on radiomic features with prior shape level set and metaheuristic algorithms

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“…The filter responses are quantified using mean, standard deviation (SD), and entropy. 34 ST features are formed by gradient of images and obtained from the Jacobian matrix. It is used to explore the structural variations in MR images.…”