Multi pH-sensitive polymer–drug conjugate mixed micelles for efficient co-delivery of doxorubicin and curcumin to synergistically suppress tumor metastasis

Zhou, Yiming; Zhou, Chuhang; Zou, Yang; Jin, Yongxing; Han, Shidi; Liu, Qi; Hu, Xinping; Wang, Leqi; Ma, Yining; Liu, Yan

doi:10.1039/d0bm00840k

Cited by 28 publications

(20 citation statements)

References 48 publications

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“…Smart nanomaterials (e.g., pH-sensitive and redox-sensitive nanoparticles) can be applied for targeted delivery of curcumin and DOX, to release their cargo in response to the tumor microenvironment. Besides, the surface of nanoparticles can be modified by receptors and ligands (such as hyaluronic acid and RGD) to promote accumulation in cancer cells (Figure 6) [222][223][224][225][226][227][228][229][230][231][232][233][234]. In Table 3, different nanocarriers applied for codelivery of curcumin and DOX are described.…”

Section: Codelivery Via Biological Nanovehiclesmentioning

confidence: 99%

Polychemotherapy with Curcumin and Doxorubicin via Biological Nanoplatforms: Enhancing Antitumor Activity

et al. 2020

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Doxorubicin (DOX) is a well-known chemotherapeutic agent extensively applied in the field of cancer therapy. However, similar to other chemotherapeutic agents such as cisplatin, paclitaxel, docetaxel, etoposide and oxaliplatin, cancer cells are able to obtain chemoresistance that limits DOX efficacy. In respect to dose-dependent side effect of DOX, enhancing its dosage is not recommended for effective cancer chemotherapy. Therefore, different strategies have been considered for reversing DOX resistance and diminishing its side effects. Phytochemical are potential candidates in this case due to their great pharmacological activities. Curcumin is a potential antitumor phytochemical isolated from Curcuma longa with capacity of suppressing cancer metastasis and proliferation and affecting molecular pathways. Experiments have demonstrated the potential of curcumin for inhibiting chemoresistance by downregulating oncogene pathways such as MMP-2, TGF-β, EMT, PI3K/Akt, NF-κB and AP-1. Furthermore, coadministration of curcumin and DOX potentiates apoptosis induction in cancer cells. In light of this, nanoplatforms have been employed for codelivery of curcumin and DOX. This results in promoting the bioavailability and internalization of the aforementioned active compounds in cancer cells and, consequently, enhancing their antitumor activity. Noteworthy, curcumin has been applied for reducing adverse effects of DOX on normal cells and tissues via reducing inflammation, oxidative stress and apoptosis. The current review highlights the anticancer mechanism, side effects and codelivery of curcumin and DOX via nanovehicles.

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Section: Codelivery Via Biological Nanovehiclesmentioning

confidence: 99%

Polychemotherapy with Curcumin and Doxorubicin via Biological Nanoplatforms: Enhancing Antitumor Activity

et al. 2020

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“…The micelles, commonly composed of amphiphilic copolymer, were able to self-assemble with core/shell structure in aqueous solution and DOX were efficiently encapsulated in the core of the micelles to achieve better solubility and bioavailability. However, there are still challenges in terms of early drug release in blood circulation and sustained drug release in tumor sites (Zhou et al., 2020 ).…”

Section: Discussionmentioning

confidence: 99%

“…It was not surprising that the size of micelles measured by DLS was slightly larger than that measured by TEM, which is probably because TEM samples are usually prepared in a dry state while the copolymer may swell in aqueous solutions measured by DLS (Wei et al., 2016 ). The antifouling properties of PEG shell, optimal shape and size of mPEG-S-PBLG micelles may reduce the protein adsorption, prolong the blood circulation, and efficiently deliver anti-cancer drugs into the tumor site through the EPR effect (Zhou et al., 2020 ). Furthermore, to ensure a sufficient dose of drugs to be delivered to tumor sites, an ideal drug delivery system should achieve high DLC as well as DLE.…”

Section: Discussionmentioning

confidence: 99%

Targeted delivery by pH-responsive mPEG-S-PBLG micelles significantly enhances the anti-tumor efficacy of doxorubicin with reduced cardiotoxicity

Feng

Liu

et al. 2021

Drug Delivery

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“…However, a weak fluorescence signal was observed in the tumor site of the mice treated with free Ce6. Designing nanoplatforms responsive to pH, enzymes, and photothermal stimuli is critical to enhance cellular uptake and control PS release [79][80][81]. Nanoplatforms responsive to pH undergo conformational changes through various mechanisms, such as pro-tonation, charge inversion, or chemical bond cleavage, promoting tumor-specific cellular uptake or drug release [82].…”

Section: Amino-acid-modulated Self-assembly Of Functional Moleculementioning

confidence: 99%

Self-assembly of amino acids toward functional biomaterials

Ren¹,

Wu²,

Tan³

et al. 2021

Beilstein J. Nanotechnol.

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Biomolecules, such as proteins and peptides, can be self-assembled. They are widely distributed, easy to obtain, and biocompatible. However, the self-assembly of proteins and peptides has disadvantages, such as difficulty in obtaining high quantities of materials, high cost, polydispersity, and purification limitations. The difficulties in using proteins and peptides as functional materials make it more complicate to arrange assembled nanostructures at both microscopic and macroscopic scales. Amino acids, as the smallest constituent of proteins and the smallest constituent in the bottom-up approach, are the smallest building blocks that can be self-assembled. The self-assembly of single amino acids has the advantages of low synthesis cost, simple modeling, excellent biocompatibility and biodegradability in vivo. In addition, amino acids can be assembled with other components to meet multiple scientific needs. However, using these simple building blocks to design attractive materials remains a challenge due to the simplicity of the amino acids. Most of the review articles about self-assembly focus on large molecules, such as peptides and proteins. The preparation of complicated materials by self-assembly of amino acids has not yet been evaluated. Therefore, it is of great significance to systematically summarize the literature of amino acid self-assembly. This article reviews the recent advances in amino acid self-assembly regarding amino acid self-assembly, functional amino acid self-assembly, amino acid coordination self-assembly, and amino acid regulatory functional molecule self-assembly.

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Multi pH-sensitive polymer–drug conjugate mixed micelles for efficient co-delivery of doxorubicin and curcumin to synergistically suppress tumor metastasis

Abstract: Combination therapy has been proved to be an effective strategy to inhibit metastasis, however, its efficacy was always compromised by the poor delivery efficiency of drugs. In this study, multi...

Cited by 28 publications

References 48 publications

Polychemotherapy with Curcumin and Doxorubicin via Biological Nanoplatforms: Enhancing Antitumor Activity

Polychemotherapy with Curcumin and Doxorubicin via Biological Nanoplatforms: Enhancing Antitumor Activity

Targeted delivery by pH-responsive mPEG-S-PBLG micelles significantly enhances the anti-tumor efficacy of doxorubicin with reduced cardiotoxicity

Self-assembly of amino acids toward functional biomaterials

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