Multi-Omics Research Strategies for Psoriasis and Atopic Dermatitis

Guo, Youming; Luo, Lingling; Zhu, Jing; Li, Chengrang

doi:10.3390/ijms24098018

Cited by 8 publications

(7 citation statements)

References 112 publications

(99 reference statements)

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“…Following the completion of the Human Genome Project in 2001, advancements in technology have facilitated the affordable study of the entire genome instead of isolated variants or single genes [ 17 ]. Genome-wide association studies (GWAS) analyzed several million genetic markers or single nucleotide polymorphisms (SNP) across the genome in large populations, allowing for the detection of subtle differences in allele frequencies between psoriatic individuals and healthy controls [ 9 ].…”

Section: Resultsmentioning

confidence: 99%

Genetic and Epigenetic Mechanisms of Psoriasis

Arrom

Puig

2023

Genes

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Psoriasis is a disease involving the innate and adaptative components of the immune system, and it is triggered by environmental factors in genetically susceptible individuals. However, its physiopathology is not fully understood yet. Recent technological advances, especially in genome and epigenome-wide studies, have provided a better understanding of the genetic and epigenetic mechanisms to determine the physiopathology of psoriasis and facilitate the development of new drugs. This review intends to summarize the current evidence on genetic and epigenetic mechanisms of psoriasis.

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Section: Resultsmentioning

confidence: 99%

Genetic and Epigenetic Mechanisms of Psoriasis

Arrom

Puig

2023

Genes

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“…First of all, a key point in making the information generated by the integration of these omics data usable is both the high number of different variants and the identification of differences through data normalization and dimensionality reduction [ 50 ]. This is possible through a multistage approach with initial emphasis or a multimodal approach.…”

Section: Integrative Multiomics Approach To Skinmentioning

confidence: 99%

“…In the former case, various types of omics data are initially incorporated into the target model creation procedure, followed by the application of the molecular data from the different omics to the target model individually to produce the final model results. In contrast, the multimodal approach involves the integration of multiple omics profiles in a simultaneous analysis, with an analytical model based on machine learning [ 50 ].…”

Section: Integrative Multiomics Approach To Skinmentioning

confidence: 99%

“…The use of such platforms may prove useful in integrating and re-analyzing information in search of molecular interactions involved in the pathogenesis of numerous skin diseases to develop and support more precise hypotheses. This software is necessary to complete various databases, such as the Human Metabolome Database that provides specific molecular profiles [ 50 ].…”

Section: Integrative Multiomics Approach To Skinmentioning

confidence: 99%

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Integrative Multiomics Approach to Skin: The Sinergy between Individualised Medicine and Futuristic Precision Skin Care?

Dessì,

Pintus,

Fanos

et al. 2024

Metabolites

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The skin is a complex ecosystem colonized by millions of microorganisms, the skin microbiota, which are crucial in regulating not only the physiological functions of the skin but also the metabolic changes underlying the onset of skin diseases. The high microbial colonization together with a low diversity at the phylum level and a high diversity at the species level of the skin is very similar to that of the gastrointestinal tract. Moreover, there is an important communication pathway along the gut–brain–skin axis, especially associated with the modulation of neurotransmitters by the microbiota. Therefore, it is evident that the high complexity of the skin system, due not only to the genetics of the host but also to the interaction of the host with resident microbes and between microbe and microbe, requires a multi-omics approach to be deeply understood. Therefore, an integrated analysis, with high-throughput technologies, of the consequences of microbial interaction with the host through the study of gene expression (genomics and metagenomics), transcription (transcriptomics and meta-transcriptomics), and protein production (proteomics and meta-proteomics) and metabolite formation (metabolomics and lipidomics) would be useful. Although to date very few studies have integrated skin metabolomics data with at least one other ‘omics’ technology, in the future, this approach will be able to provide simple and fast tests that can be routinely applied in both clinical and cosmetic settings for the identification of numerous skin diseases and conditions. It will also be possible to create large archives of multi-omics data that can predict individual responses to pharmacological treatments and the efficacy of different cosmetic products on individual subjects by means of specific allotypes, with a view to increasingly tailor-made medicine. In this review, after analyzing the complexity of the skin ecosystem, we have highlighted the usefulness of this emerging integrated omics approach for the analysis of skin problems, starting with one of the latest ‘omics’ sciences, metabolomics, which can photograph the expression of the genome during its interaction with the environment.

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“…Atopic dermatitis (AD) is the most common chronic cutaneous IMID, with a prevalence of 10% among adults and 20% in children [13]. The underlying pathophysiological mechanisms in AD are complex, encompassing a pronounced genetic susceptibility, epidermal dysfunction, and inflammation driven by T-cells [14][15][16][17][18]. Both the innate and adaptive immune systems contribute to its etiopathogenesis [14,16].…”

Section: Current Knowledge In Pathogenesis Of Atopic Dermatitis and P...mentioning

confidence: 99%

Multi-Omics Approach to Improved Diagnosis and Treatment of Atopic Dermatitis and Psoriasis

Rusiñol,

Puig

2024

IJMS

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Psoriasis and atopic dermatitis fall within the category of cutaneous immune-mediated inflammatory diseases (IMIDs). The prevalence of IMIDs is increasing in industrialized societies, influenced by both environmental changes and a genetic predisposition. However, the exact immune factors driving these chronic, progressive diseases are not fully understood. By using multi-omics techniques in cutaneous IMIDs, it is expected to advance the understanding of skin biology, uncover the underlying mechanisms of skin conditions, and potentially devise precise and personalized approaches to diagnosis and treatment. We provide a narrative review of the current knowledge in genomics, epigenomics, and proteomics of atopic dermatitis and psoriasis. A literature search was performed for articles published until 30 November 2023. Although there is still much to uncover, recent evidence has already provided valuable insights, such as proteomic profiles that permit differentiating psoriasis from mycosis fungoides and β-defensin 2 correlation to PASI and its drop due to secukinumab first injection, among others.

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Multi-Omics Research Strategies for Psoriasis and Atopic Dermatitis

Cited by 8 publications

References 112 publications

Genetic and Epigenetic Mechanisms of Psoriasis

Genetic and Epigenetic Mechanisms of Psoriasis

Integrative Multiomics Approach to Skin: The Sinergy between Individualised Medicine and Futuristic Precision Skin Care?

Multi-Omics Approach to Improved Diagnosis and Treatment of Atopic Dermatitis and Psoriasis

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