Multi-layered proteomics identifies insulin-induced upregulation of the EphA2 receptor via the ERK pathway and dependent on low IGF1R level
Sarah Hyllekvist Jørgensen,
Kristina Bennet Emdal,
Anna-Kathrine Pedersen
et al.
Abstract:Insulin resistance impairs the cellular insulin response and frequently precedes metabolic disorders, like type 2 diabetes, which are affecting an increasing number of people globally. Given the critical role of the liver in glucose and lipid metabolism, understanding the molecular mechanisms in hepatic insulin resistance is essential for early preventive treatments. To elucidate changes in insulin signal transduction associated with hepatocellular resistance, we employed a multi-layered mass spectrometry-base… Show more
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