Multi-layered polycaprolactone–alginate–fucoidan biocomposites supplemented with controlled release of fucoidan for bone tissue regeneration: fabrication, physical properties, and cellular activities

Jin, Gyuhyun; Kim, GeunHyung

doi:10.1039/c2sm07256d

Cited by 19 publications

(6 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition to cell encapsulation, alginate has been proposed for several other applications in the biomedical field [3]. For example, alginate-based scaffolds containing hydroxyapatite showed structural features similar to those of the trabecular bone [9][10][11][12], and in combination with silver nanoparticles, as well as having antimicrobial properties, have shown good osteointegration in in vivo models [12].…”

Section: Introductionmentioning

confidence: 99%

Rheology of mixed alginate-hyaluronan aqueous solutions

Travan

Fiorentino

Grassi

et al. 2015

International Journal of Biological Macromolecules

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Rheology of mixed alginate-hyaluronan aqueous solutions

Travan

Fiorentino

Grassi

et al. 2015

International Journal of Biological Macromolecules

View full text Add to dashboard Cite

“…The same group attempted to control the release profile of fucoidan by first constructing polycaprolactone structures and then covering it with a mixture of alginate and fucoidan because burst release was detected in the study mentioned above. The results of this approach demonstrated active biological capabilities for promoting bone regeneration in comparison to the polycaprolactone and fucoidan composite without release or with burst release of fucoidan ( Jin and Kim, 2012 ). The biomineralization studies of the scaffold made of polycaprolactone and fucoidan and polycaprolactone with a mixture of alginate and fucoidan have been shown in Figure 9 .…”

Section: Fucoidan For Bone Tissue Engineeringmentioning

confidence: 99%

Section: Fucoidan For Bone Tissue Engineeringmentioning

confidence: 99%

Unveiling the secrets of marine—derived fucoidan for bone tissue engineering—A review

Udduttula²,

Jaiswal³

2023

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Biomedical uses for natural polysaccharides of marine origin are growing in popularity. The most prevalent polysaccharides, including alginates, agar, agarose and carrageenan, are found in seaweeds. One among these is fucoidan, which is a sulfated polysaccharide derived from brown algae. Compared to many of the biomaterials of marine origin currently in research, it is more broadly accessible and less expensive. This polysaccharide comes from the same family of brown algae from which alginate is extracted, but has garnered less research compared to it. Although it was the subject of research beginning in the 1910’s, not much has been done on it since then. Few researchers have focused on its potential for biomedical applications; nevertheless, a thorough knowledge of the molecular mechanisms behind its diverse features is still lacking. This review provides a quick outline of its history, sources, and organization. The characteristics of this potential biomaterial have also been explored, with a thorough analysis concentrating on its use in bone tissue engineering. With the preclinical research completed up to this point, the fucoidan research status globally has also been examined. Therefore, the study might be utilized as a comprehensive manual to understand in depth the research status of fucoidan, particularly for applications related to bone tissue engineering.

show abstract

“…[32][33][34] To effectively regulate the release of biocompatible components, controllable release is required. In our previous works, we investigated the controlled release of various bioactive components, such as fucoidan 35 and sulfuretin, 36 using a coated alginate to avoid an initial biocomponent burst effect. In this work, we also employed a similar system using the coated collagen/ alginate component.…”

Section: 25mentioning

confidence: 99%

A polycaprolactone/fish collagen/alginate biocomposite supplemented with phlorotannin for hard tissue regeneration

Park

Mun

et al. 2017

RSC Adv.

Self Cite

View full text Add to dashboard Cite

In tissue engineering, scaffolds have been widely studied for the purpose of regenerating damaged tissues or organs. Biocompatibility of materials, pore structure, and even growth factors are effective for enhancing cell growth and differentiation. In particular, mammalian collagen is biocompatible and hydrophilic, and provides good cell attachment due to interactions between Arg-Gly-Asp (RGD) domains and cell membranes. However, there have been some limitations on the use of mammalian collagen. In this study, we present a biocomposite scaffold supplemented with collagen extracted from fish skin and phlorotannin from brown algae. The effect of these biocomponents on various physical characteristics, including water wetting ability and tensile properties, was observed. The in vitro cellular activities of the biocomposites were examined using osteoblast-like cells (MG63) to assess cell proliferation and mineralization. The results show that the cells were more highly proliferated on the phlorotannin/fish collagen/alginate biocomposite compared to the control (collagen/alginate). Furthermore, the biocomposite showed significantly higher in vitro calcium deposition (38.37%) and osteogenesis (43.2%), determined by histomorphometric analysis, than the control. Based on these results, the biocomposite supplemented with fish collagen/phlorotannin was demonstrated to be a good potential biomaterial for enhancing bone tissue growth.

show abstract

Multi-layered polycaprolactone–alginate–fucoidan biocomposites supplemented with controlled release of fucoidan for bone tissue regeneration: fabrication, physical properties, and cellular activities

Cited by 19 publications

References 42 publications

Rheology of mixed alginate-hyaluronan aqueous solutions

Rheology of mixed alginate-hyaluronan aqueous solutions

Unveiling the secrets of marine—derived fucoidan for bone tissue engineering—A review

A polycaprolactone/fish collagen/alginate biocomposite supplemented with phlorotannin for hard tissue regeneration

Contact Info

Product

Resources

About