Multi-exponential relaxation analysis with MR imaging and NMR spectroscopy using fat-water systems

Kamman, R. L.; Bakker, C. J. G.; Dijk, Pim van; Stomp, G.P.; Heiner, A.P.; Berendsen, Herman J. C.

doi:10.1016/0730-725x(87)90127-5

Cited by 43 publications

(29 citation statements)

References 9 publications

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“…Previous human studies (21)(22)(23)(24)(25)(26) have shown statistically significant correlations between imaging and spectroscopic FFs, but the accuracy of imaging relative to that of spectroscopy has been inconsistent. Imaging FF generally has been calculated from fat and water signal intensities (rather than PDs) and therefore has been affected by sequence type (23,27,28), imaging parameters (28)(29)(30)(31), and tissue relaxation properties (32-34) due to confounding T1 and T2* (or T2) relaxation effects.…”

Section: Methodsmentioning

confidence: 95%

Nonalcoholic Fatty Liver Disease: Diagnostic and Fat-Grading Accuracy of Low-Flip-Angle Multiecho Gradient-Recalled-Echo MR Imaging at 1.5 T

et al. 2009

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Section: Methodsmentioning

confidence: 95%

Nonalcoholic Fatty Liver Disease: Diagnostic and Fat-Grading Accuracy of Low-Flip-Angle Multiecho Gradient-Recalled-Echo MR Imaging at 1.5 T

et al. 2009

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“…In using this correction, components of lipid resonances with short T, (T2 < 50 ms, (26)) have a much broadened PSF with increased sidelobe amplitudes (Fig. 3c).…”

Section: T Effects On Resolutionmentioning

confidence: 94%

Fast proton spectroscopic imaging of human brain using multiple spin‐echoes

Duyn

Moonen

1993

Magnetic Resonance in Med

139

125

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We introduce a multi-echo multi-slice MR proton spectroscopic imaging method, which allows for a dramatic reduction of the measurement time by acquiring multiple spin-echoes within a single repetition time. In the multi-echo multi-slice experiment discussed in this paper, a threefold reduction in measurement time is obtained by sacrificing some spectral resolution. Signal-to-noise ratio and spatial resolution are preserved. Metabolite images of N-acetyl aspartate, and total choline+total creatine from multiple slices through the human brain are presented and compared with images obtained with a conventional single-echo multi-slice method.

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“…With use of a multiecho GRE sequence with multiple flip angles or repetition times, it is possible to obtain estimates of the proton density, T1, and T2* of the fat and water signal components by plugging the data into the equation (46). Nonlinear curve-fitting algorithms are now standard in most commercial statistical analysis software packages.…”

Section: T1-and T2*-corrected Fat Quantification-mentioning

confidence: 99%

Fatty Liver Disease: MR Imaging Techniques for the Detection and Quantification of Liver Steatosis

Cassidy¹,

Yokoo²,

Aganović³

et al. 2009

RadioGraphics

248

209

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Fatty liver disease is the most common cause of chronic liver disease in the United States. Noninvasive detection and quantification of fat is becoming more and more important clinically, due in large part to the growing prevalence of nonalcoholic fatty liver disease. Steatosis, the accumulation of fat-containing vacuoles within hepatocytes, is a key histologic feature of fatty liver disease. Liver biopsy, the current standard of reference for the assessment of steatosis, is invasive, has sampling errors, and is not appropriate in some settings. Several magnetic resonance (MR) imaging-based techniques--including chemical shift imaging, frequency-selective imaging, and MR spectroscopy--are currently in clinical use for the detection and quantification of fat-water admixtures, with each technique having important advantages, disadvantages, and limitations. These techniques permit the breakdown of the net MR signal into fat and water signal components, allowing the quantification of fat in liver tissue, and are increasingly being used in the diagnosis, treatment, and follow-up of fatty liver disease.

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Multi-exponential relaxation analysis with MR imaging and NMR spectroscopy using fat-water systems

Cited by 43 publications

References 9 publications

Nonalcoholic Fatty Liver Disease: Diagnostic and Fat-Grading Accuracy of Low-Flip-Angle Multiecho Gradient-Recalled-Echo MR Imaging at 1.5 T

Nonalcoholic Fatty Liver Disease: Diagnostic and Fat-Grading Accuracy of Low-Flip-Angle Multiecho Gradient-Recalled-Echo MR Imaging at 1.5 T

Fast proton spectroscopic imaging of human brain using multiple spin‐echoes

Fatty Liver Disease: MR Imaging Techniques for the Detection and Quantification of Liver Steatosis

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