PLoS ONE volume 9, issue 6, Pe98391 2014 DOI: 10.1371/journal.pone.0098391 View full text
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Ashish Raj, Sneha Pandya, Xiaobo Shen, Eve LoCastro, Thanh D. Nguyen, Susan A. Gauthier

Abstract: The brain’s myelin content can be mapped by T2-relaxometry, which resolves multiple differentially relaxing T2 pools from multi-echo MRI. Unfortunately, the conventional fitting procedure is a hard and numerically ill-posed problem. Consequently, the T2 distributions and myelin maps become very sensitive to noise and are frequently difficult to interpret diagnostically. Although regularization can improve stability, it is generally not adequate, particularly at relatively low signal to noise ratio (SNR) of aro…

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